Filetype
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address this heterogeneity a previous study clustered people with diabetes into five diabetes subtypes. The aim of the current study is to investigate the aetiology of these clusters by comparing their molecular signatures. In three independent cohorts, in total 15,940 individuals were clustered based on five clin
Incorporating time as a unit of analysis can enrich the study of agency by showing the specific ways in which actors are temporally constrained when responding to economic disturbances. In this paper, this is done by examining how the behavior of actors is affected by timing norms such as term limits that may be associated with an actor's position, as for example, an elected mayor or university vi
Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of pat
In this article we build on the concept of incompleteness, as recently developed in both organisational and urban studies, to improve our understanding of the collective actions of grassroots organisations in creating and governing critical infrastructures in the changing and resource-scarce contexts of urban informal settlements. Empirically, the article is informed by the case of resident associ
Purpose: The purpose of this article is to offer new insights into crisis communication in service ecosystems. The authors present a framework to conceptually categorize service crises and then analyze key aspects of crisis communication among different stakeholders in a service ecosystem. Design/methodology/approach: Building on crisis communication and service ecosystems research, we propose a f
The resistance and resilience provided by functional redundancy, a common feature of microbial communities, is not always advantageous. An example is nitrite oxidation in partial nitritation-anammox (PNA) reactors designed for nitrogen removal in wastewater treatment, where suppression of nitrite oxidizers like Nitrospira is sought. In these ecosystems, biofilms provide microhabitats with oxygen g
Cells in vivo are subjected continuously to multiple biochemical and biophysical stimuli from their microenvironment that regulate cell fate and function. Although two-dimensional (2D) platforms to check cell responses to various microenvironmental factors have been established, these methods lack physiological relevance. Macroscale three-dimensional (3D) cell culture platforms were developed to p
Compared to other regions, the drivers of diversification in Africa are poorly understood. We studied a radiation of insects with over 100 species occurring in a wide range of habitats across the Afrotropics to investigate the fundamental evolutionary processes and geological events that generate and maintain patterns of species richness on the continent. By investigating the evolutionary history
Introduction: Movement quality, represented in unrestricted movements, flow and pleasure, is often lacking in people with autism. One aspect is the non-verbal expression of the present emotional and psychological state of an individual. Purpose: To describe the meaning of movement quality in autism, as experienced by specialized physiotherapists. Method: Ten physiotherapists were interviewed. The
Open Source receives high attention among organizations today, and there is also a growing interest on Open Source Enterprise Resource Planning (OS ERP) systems. Open source development is often considered having a high level of involvement from stakeholders in adopting organizations. However, it depends on for the first what is meant by stakeholders, but also what is meant by involvement. In the
Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst
Purpose: The purpose of the paper is to build on current discussions about the need for and role of guidance in learning and teaching, as well as to theoretically develop its specifics to further advance our scholarly understanding of how to structure and enhance entrepreneurship education. Design/methodology/approach: The paper takes a synthesizing conceptual approach, built on developmental psyc
The stellar-to-halo mass relation (SHMR) is not only one of the main sources of information we have on the connection between galaxies and their dark matter haloes, but also an important indicator of the performance of galaxy formation models. Here, we use one of the largest sample of galaxies with both high-quality rotation curves and near-infrared surface photometry, and perform a detailed compa
Seaweeds (macroalgae) are gaining attention as potential sustainable feedstock for the production of fuels and chemicals. This comparative study focuses on the characterization of the microbial production of alcohols from fermentable carbohydrates in the hydrolysate of the macroalgae Laminaria digitata as raw material. The potential of a hydrolysate as a carbon source for the production of selecte
Joel Penney made an innovative, interdisciplinary intervention into the scholarship on political participation with The Citizen Marketer: Promoting Political Opinion in the Social Media Age. By melding modern marketing frameworks with democratic theory, Penney offered a timely heuristic for rethinking citizens’ engagement with politics on social media. The “citizen marketer approach” developed in
Planar imaging was for a long time the most-used technique for image-based activity quantification. Owing to its simplicity and speed, the possibility to acquire dynamic image sequences, and to generate whole-body images at a reasonable acquisition time, it is still frequently used in nuclear-medicine imaging. Today, planar imaging is most commonly used for diagnostic examinations with qualitative
The design of Sensory Substitution Devices (SSDs) often relies on the belief that the information supplied by the devices should allow the construction of spatial mental representations on the basis of which routes are planned. This study, in contrast, illustrates that navigation using an SSD can be conceived as an on-line, dynamic process, without the need for establishing a predefined plan or mo
During the late 19th and the early 20th century there was an unprecedented development in medical research. Tissue and cell culture rapidly developed into areas with many contributing scientists. The same is true for tissue transplantation. When these achievements are described afterwards in a historical context and a mainline development is constructed, there are researchers whose pioneering work
α-Synuclein (aSyn) is a 140 residue long protein present in presynaptic termini of nerve cells. The protein is associated with Parkinson's disease, in which case it has been found to self-Assemble into long amyloid fibrils forming intracellular inclusions that are also rich in lipids. Furthermore, its synaptic function is proposed to involve interaction with lipid membranes, and hence, it is of in
Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointl
