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BACKGROUND: The use of global gene expression profiling is a well established approach to understand biological processes. One of the major goals of these investigations is to identify sets of genes with similar expression patterns. Such gene signatures may be very informative and reveal new aspects of particular biological processes. A logical and systematic next step is to reduce the identified
Uncertainty in our calculations of a system reveals the limits of our knowledge. This limitation makes model representations of the Earth system challenging and our predictions less reliable. However, despite appearing chaotic and non-linear, a system always follows a deterministic trajectory, which can often be expressed probabilistically. Building on this concept, this thesis applies data assimi
For decades, the environmental sciences have engaged in measuring and modelling natural systems to increase our understanding and prediction of climate change. This thesis advances these efforts by analyzing and applying in-situ instruments, remote sensing, and modelling approaches. The main focus lies in utilizing a state-of-the-art global Earth System Model (ESM) EC-Earth3, which is used to simu
Lately, interest has increased in using Virtual Reality (VR) in residential care facilities to increase accessibility to nature experiences. It is widely acknowledged that nature benefits health, and various theories exist regarding its restorative effects. Studies of virtual natural environments often start from predetermined mediating mechanisms and health outcomes. However, virtual nature is fu
The history of spinal cord injuries starts with the ancient Egyptian medical papyrus known as the Edwin Smith Surgical Papyrus. The papyrus written about 2500 B.C.by the physician and architect of the Sakkara pyramids Imhotep, describes "crushed vertebra in his neck" as well as symptoms of neurological deterioration. An ailment not to be treated was the massage to the patients at that time. This f
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s contribution to high-risk disease are not completely understood. Herein, we implemented an integrative approach combining publicly available RNA-S
In laboratory medicine, much effort has been put into analytical quality in the past decades, making this medical profession one of the most standardized with the lowest rates of error. However, even the best analytical quality cannot compensate for errors or low quality in the pre or postanalytical phase of the total testing process. Guidelines for data reporting focus solely on defined data elem
This thesis addresses how graphene can be a valuable asset for surface science studies. Using a combination of X- ray photoelectron spectroscopy, scanning tunneling microscopy, and low-energy electron diffraction, we take advantage of graphene’s sensitivity to changes in its chemical environment to obtain an atomic scale understanding of different reactions occurring above and below the film.As a
Internationalisation of higher education is a current theme in research and politics of higher education. The theme in this paper is related to present developments and concerns of the growing border-crossing activities that take place between nations and their systems of Higher Education. Higher education is expected to be based on research, research to be an international activity, and the unive
Monitoring natural events at ultrafast timescales is a prerequisite for our continued understanding of physical, chemical and biological processes. Due to exponential advancements in knowledge and optical technology, the field of ultrafast videography has seen a sudden uptick in activity beginning in the mid-2010s. Today, the field has matured past its infancy and is slowly becoming a standard too
Automation with the use of robotics is a crucial trend across industries, enhancing efficiency and quality while improving health and safety conditions by minimizing human exposure to hazardous tasks. Alfa Laval, a global provider of products within heat transfer, separation, and fluid handling, is embracing this trend by exploring how to solve labor-intensive processes like the production of rubb
Denna rapport redogör för design och utveckling av ett medicintekniskt instrument för diagnos av kronisk obstruktiv lungsjukdom (KOL) eller emfysem. Arbetet utgår ifrån en ny diagnosmetod och ett instrument i form av en funktionell prototyp som används för att testa den nya diagnosmetoden. Med utgångspunkt i den funktionella prototypen har arbetet fokuserats kring att förstå vilka problem och utmThis thesis presents design and development of a medical device for diagnosis of emphysema or COPD by controlled lung deposition of nanoparticles. After purging the lungs with particle free air the subject inhales a controlled aerosol mixture and holds his breath for a determined period of time, before exhaling. The degree of lung disease is calculated by measuring and comparing the concentration
Background: Most literature on second primary cancers (SPCs) focuses on possible factors, which may increase the risk of these cancers, and little attention has been paid for the overall incidence differences between first primary cancers (FPCs) and same SPCs. We wanted to compare the incidence rates for all common cancers when these were diagnosed as FPCs and SPCs after invasive and in situ squam
Denna uppsats har haft som syfte att behandla frågorna om AI-genererade verk kan omfattas av upphovsrättsligt skydd enligt gällande svensk rätt, var gränsen för mänsklig medverkan i AI-skapade verk kan dras samt om upp-hovsrätten bör utvecklas för att möta denna tekniska utveckling. Utgångs-punkten har varit 1 kap. 1 § i upphovsrättslagen och det EU-harmoniserade originalitetskravet, enligt vilketThis thesis examines whether AI-generated works can be covered by copy-right protection under current Swedish law, where the limit for human partici-pation in AI-generated works should be drawn, and whether copyright law should be developed to meet this advancement. The basis of the thesis has been Chapter 1, Section 1 of the Swedish Copyright Act (Upphovsrättslagen) and the EU-harmonized original
The aim of this Master´s thesis is to explore how the public libraries in Sweden work with children´s and youth´s independent, aesthethic and artistic creations and play as new ways for stimulating and developing children´s reading. The method is a literature study which gives an overview of the theories and the research on Children´s culture concept and The Concept of participation, the meaning o
Organic solar cells made of polymers are an attractive alternative to the conventional solar cells which are commercially used today. The polymer solar cell is cheap to produce, due to the high absorption coefficients which limits the needed thickness of the material and due to the simple manufacturing process, which doesn’t demand high temperatures. However, the efficiencies of polymer solar cell
Hemodialysis is today the main treatment used for patients with renal impairment, a serious medical condition. Hemodialysis treatment handles a very delicate system which is why it is of the utmost importance that the dialysis machine has got a reliable safety monitoring system that can detect severe complications during treatment. A new such system is currently under development at Gambro, Lund,
Abstract Author: Annelie Paulsson Title: They are so charming individuals – About Children’s Advocacy centres (”Barnahus”), collaboration and the child’s right to be listen to. Supervisor: Claes Levin Assessor: Staffan Blomberg The purpose of this study was to examine how children are treated, to what extent they are allowed a voice of their own, and whether or not this voice is heard in the proce
The construction and real estate sector is a major contributor to global carbon emissions and climate change. Ventilation systems, although essential for maintaining indoor air quality and occupant health, account for a significant share of building operational emissions. In HVAC systems, duct layouts significantly influence ventilation impacts through both the embodied carbon from material produc
