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OBJECTIVES:To report the initial experience of an international group of investigators in identifying mutations in the BRCA1 breast and ovarian cancer susceptibility gene, to assess the spectrum of such mutations in samples from patients with different family histories of cancer, and to determine the frequency of recurrent mutations.DESIGN:Nine laboratories in North America and the United Kingdom
Problem: Refugee entrepreneurship has recently garnered a growing academic and political interest around the world. The rate of scientific publication has soared in the last few years due to the scholarly urgency on the topic following the ‘global refugee crises’. Nevertheless, the research field is currently underdeveloped with existing knowledge dispersed across various and often disconnected di
Background: Several studies described the cross-sectional characteristics of systemic sclerosis patients and coexisting primary biliary cholangitis, but longitudinal prognostic data are lacking. Aims: To describe the systemic sclerosis–primary biliary cholangitis phenotype, including baseline characteristics and outcomes. Methods: We performed a multicentre the European Scleroderma Trials and Rese
The design and synthesis of three star-shaped nonfullerene (NFA) acceptors, TPA-2T-INCN, TPA-2T-BAB, and TPA-T-INCN, based on a triphenylamine (TPA) core and linked through π-conjugated thiophene (T) spacers to different terminal units (3-oxo-2,3-dihydro-1H-inden-1-ylidene) malononitrile, INCN, and 1,3-dimethylbarbituric acid, BAB), are reported. These materials are blended with the widely used po
Building information modeling (BIM) and building energy modeling (BEM) are two key tools to make the transition to net-zero energy buildings (NZEB). However, a recent literature review indicated that the conversion from BIM to BEM is currently dysfunctional, due to limitations regarding competencies, processes, and technology. In this article, a case study is presented to show how the information
PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes on subtyping while considering a tumor’s underlying clinical subgroup defined by ER, PR, and HER2 status. To do this we used a population-representative and c
Despite increased attention to climate finance in urban adaptation, empirical data on the socio-political processes shaping funding accessibility, allocation, and their implications for inter-urban adaptation progress remains limited. In a first-of-its-kind survey, we analyse results from 148 urban administrations across 17 EU countries. Our results reveal widespread funding shortages (>85% of adm
Structural design and risk management typically involve uncertainties related to structural performance and loading conditions, which must be effectively managed to ensure compliance with safety requirements. Additionally, the relationships among parameters influencing structural performance are often complex and not easily discernible, thereby complicating the decision-making process. To address
Johan Ekeblad was a Swedish diplomat and nobleman during the period of the Swedish Empire in the 17th century who is mostly known for his letters, written in an impressionistic and highly modern style. This paper aims to treat Johan Ekeblad and his writing as a representative of a new form of mentality that emerged amongst Swedes when Sweden due to its new power reemerged on the European scene. Th
Popular Abstract in Swedish Det övergripande syftet med denna avhandling var att lyfta fram barns kreativitet och barnens egna perspektiv på kreativitet, som en kontrast till studier som undersöker begreppet ur ett vuxenperspektiv och utifrån en akademisk definition. Avhandlingen består av två kvasi-experimentella studier och en intervju studie. I Studie I undersöktes associationer mellan kreativiThe main aim of the present investigation was to highlight middle childhood creativity, and the children’s perspective on creativity, in contrast to many, if not most, studies that investigate creativity from an adult perspective and a scholarly definition. This dissertation consists of two quasi-experimental studies, and one interview study. Study I investigated if, and how, state anxiety, broug
Aims and objectives. To present data on Swedish ICU nurses’ attitudes to brain death and organ donation and to test a questionnaire designed to explore these issues in terms of validity and reliability.Background. Previous studies have identified various barriers to organ donation. The single most important factor was the attitude of ICU staff.Design. A 34‐item instrument was developed to explore
Med hjälp av ett automatiserat mätsystem för partikelhalter i vatten har vattenkvaliteten vid Borensbergs vattenverk i Motala kommun undersökts under ett års tid med avseende på mikroskopiska partiklar i dricksvatten och råvatten. Antalet mikroskopiska partiklar registrerades som absoluta värden i realtid. I denna artikel diskuteras hur larmgränser skall definieras i praktiken för partikelhalter oDuring a one year long research project at Borensberg Waterworks, Motala, Sweden, water quality with respect to microscopic particle counts both in raw water and drinking water have been monitored by an online water quality monitoring system. Microscopic particle counts were documented with absolute values in real-time. In this paper, a discussion is introduced on how to analyze large data sets fr
Innovation plays an important role in organization survival and longevity. This is especially true in the retail industry; there is a growing acknowledgment of the role of innovation in retail practice, as maintaining the status quo might prove insufficient, especially for traditional retailers, in addressing the enormous challenges they are facing driven by technological developments and evolving
Ecosystem services inherently involve people, whose values help define the benefits of nature's services. It is thus important for researchers to involve stakeholders in ecosystem services research. However, a simple and practicable framework to guide such engagement, and in particular to help researchers anticipate and consider key issues and challenges, has not been well explored. Here, we use e
An experimental study of the Homogeneous Charge Compression Ignition (HCCI) combustion process has been conducted by using chemiluminescence imaging. The major intent was to characterize the flame structure and its transient behavior. To achieve this, time resolved images of the naturally emitted light were taken. Emitted light was studied by recording its spectral content and applying different f
What are inhabitants’ perceptions and uses of windows in multi-dwelling buildings? This paper reports on a field study that explores daylight, the visual connection to the outside and the role of windows in the home during the day and night. Qualitative interviews were held with 20 participants living in multi-dwelling buildings. The thematic analysis identified two main components as characterist
Integrins are transmembrane receptors that activate signal transduction pathways upon extracellular matrix binding. The integrin-mediated adhesive complex (IMAC) mediates various cell physiological processes. Although the IMAC was thought to be specific to animals, in the past ten years these complexes were discovered in other lineages of Obazoa, the group containing animals, fungi, and several mi
