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Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract, and are collectively referred to as inflammatory bowel disease (IBD). IBD is a major cause of lifetime morbidity, has a severe impact on quality of life of patients (equivalent to that of rheumatoid arthritis, asthma, migraine, or diabetes) and constitutes a substantial economic burden to the h
Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analyzed neuronal properties of an iPSC line derived from a patient with a juvenile form of Huntington's disease (HD) carrying 72 CAG repeats (HD-iPSC). Although its i
BACKGROUND: The current trend of upgrading undervalued agricultural by-products involves the recovery of natural antioxidants. The purpose of this study was to recover phenols from fresh olive mill wastewater (OMW) with their dispersion in 85 mL ethanol per 100 mL and to investigate the effect of processing parameters on the phenol content and antioxidant capacity of the extracts. Moreover, all th
OBJECTIVE: To elucidate parent´s experience of having had a baby with colic four years previously and of how the colic and care influenced the family in a long-term perspective. METHODOLOGY AND PARTICIPANTS: A qualitative inductive follow-up study with 13 individual and one focus group interview including four parents. Altogether ten mothers and seven fathers representing 12 families, who had been
Prediction of the spread of combustion gases from a fire is a major area of interest when analyzing buildings from a safety point of view. Hence programs with this aim are continuously being evaluated for the estimation of their validity. The purpose of this report was to produce and compare complementary results for an up to date version of the program Fire Dynamics Simulator (FDS) to what was pr
How to increase trade flows in today's globalized world is a relevant topic and the incentives to do so are exemplified by the WTO Trade Facilitation Agreement that came into force in 2017. Inefficient trade procedures have proven to aggravate and decrease trade. Inefficient trade procedures could be obtaining, preparing and submitting documents about the traded good to authorities, as well as
It is not uncommon that states repress and oppress its citizens by exerting violence upon them. Sometimes this violence leads to cases where states abuse their power. This abuse can lead to terrible consequences which several historical and contemporary cases shows. When analyzing state violence, it ought to be put in the context of violence from non-state actors, which often eclipse the violence
Receiving social support is central in dealing with life events in general. Intersex or disorders of sex development (DSD) people and especially adolescents, however, have been found to be reluctant to share information about their sex development and often find themselves dealing with it on their own. A shift toward more psychosocial care for intersex/DSD people and human rights claims for more a
The study considers the phenomenon of double alienation, by which is meant the immigrant’s feeling of in a sense being alienated in their native country as well as in the new one. Those elements of their behaviour which are common in the one country or the other are expected there, whereas those which are not are seen as strange and different. This gives the immigrant a feeling of being at home in
This paper explores discourses about European colonialism and particularly Sweden's colonial legacy in Swedish upper secondary school history textbooks. All three textbooks are currently in use and are based on the latest school curricula from 2011. The theoretical framework used to analyze the textbooks consists of post-colonial feminist theories combined with a post structuralist perspective
Popular Abstract in Swedish Leukemi kännetecknas av en okontrollerad tillväxt av omogna vita blodkroppar och orsakas av förvärvade genetiska förändringar. Genetiska förändringar eller avvikelser, som är drivande i cancerutvecklingen, uppstår när normala celler delar sig. Identifiering av sådana förändringar på gen-och kromosomnivå är av stor klinisk betydelse. Behandling styrs av vilka genetiska aAcute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has a favorable prognosis, adult ALL is associated with a much poorer outcome with less than 40% overall
The implementation of gender fair language is often associated with negative reactions and hostile attacks on people who propose a change. This was also the case in Sweden in 2012 when a third gender-neutral pronoun hen was proposed as an addition to the already existing Swedish pronouns for she (hon) and he (han). The pronoun hen can be used both generically, when gender is unknown or irrelevant,
The Constructal Theory is applied to obtain better thermal performance from a type of microchannel heat sink. Based on a smooth, straight, rectangular microchannel heat sink (Case 1), three different configurations of constructal multiple bifurcation are designed for the entrance region of each microchannel. These types are one bifurcation (Case 2), two bifurcations with the second placed in the f
Substantial research and development efforts are being made to add driver support systems to the arsenal of traffic safety measures. Obviously, the system cannot reduce fatalities and trauma until it is actually used. Hence, drivers’ experiences and acceptance of the system are of paramount importance. A driver support system (ISA) has been investigated by means of real life trials in Sweden, Hung
Several articles within the area of green chemistry often promote new techniques or products as 'green' or 'more environmentally benign' than their conventional counterpart although these articles often do not quantitatively assess the environmental performance. In order to do this, life cycle assessment (LCA) is a valuable methodology. However, on the planning stage, a full-scale LCA is considere
Introduction: There is a common understanding that driving under the influence of alcohol is associated with higher risk of being involved in crashes with injuries and possible fatalities as the outcome. Various countermeasures have therefore from time to time been taken by the authorities to prevent drunk driving. One of them has been the alcohol interlock. Up to now, interlocks have mainly been
The complement system is one of the most important defence mechanisms against bacteria and pathogens. It acts within the framework of both innate and adaptive immunity. In addition to direct elimination of pathogens, complement also supports waste removal (dying cells, immune complexes, and misfolded proteins) and guides effector mechanisms of the adaptive immune response. Key events in complement
Two new solvates were prepared in the system Cu(I) I using a solvolysis reaction. The structures for both of them were solved by X-ray crystallography, showing that they constitute two modifications of the same compound with the net formula [Cu4I6](P(C6H5)(4))(2)center dot 2OC(CH3)(2). Both types of crystals show vivid fluorescence when exposed to UV light. The formation of the first modification
Popular Abstract in English Each year an estimated 530 000 new cases of cervical cancer are diagnosed and more than 275 000 women die from cervical cancer worldwide (2). Cervical cancer is caused by sexually-acquired infections with a subset of human papillomavirus (HPV) (359, 360). HPV is the most common viral infection of the anogenital tract (2). Almost all sexually active individuals will be iHuman papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the differentiation stage of the infected cells. Early HPV-16 genes are expressed in basal layers of the epithel
Background: An emergency department (ED) should offer timely care for acutely ill or injured persons that require the attention of specialized nurses and physicians. This study was aimed at exploring what is actually going on at an ED. Methods: Qualitative data was collected 2009 to 2011 at one Swedish ED (ED1) with 53.000 yearly visits serving a population of 251.000. Constant comparative analysi
