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Chronic hyperglycemia leads to pancreatic beta-cell dysfunction characterized by diminished glucose-stimulated insulin secretion (GSIS), but the precise cellular processes involved are largely unknown. Here we show that pancreatic beta-cells chronically exposed to a high glucose level displayed substantially increased amounts of stress fibers compared with beta-cells cultured at a low glucose leve

The ability of particles to activate and form cloud droplets influences the functioning of the Earth's hydrological cycle. This work links the particle water uptake at subsaturation to the critical supersaturation ratio needed for particles to become cloud condensation nuclei (CCN). Five models using the particle hygroscopic growth at subsaturation for predicting the critical supersaturation neede

Double-differential dijet cross-sections measured in pp collisions at the LHC with a 7 TeV centre-of-mass energy are presented as functions of dijet mass and half the rapidity separation of the two highest-p(T) jets. These measurements are obtained using data corresponding to an integrated luminosity of 4.5 fb(-1), recorded by the ATLAS detector in 2011. The data are corrected for detector effects

There is evidence to suggest that small businesses often start with innovative business ideas but fail within the first 3 years because the proprietors lack the expertise to make them thrive. In this context, it has been suggested that SMEs would benefit from support to select suitable ICTs that can help them to make the most of their business potential. Such suggestions tend to overlook a need to

Popular Abstract in Swedish SVENSK POPULÄRVETENSKAPLIG SAMMANFATTNING (SUMMARY IN SWEDISH) Vi kommer dagligen i kontakt med kemiska ämnen av olika slag. Med till exempel mat och dryck, läkemedel, tobaksrökning och miljögifter får vi i oss ämnen som kan vara skadliga för oss. Vi är dock utrustade med ett ordentligt reningsverk, framför allt är det levern som ser till att farliga ämnen bryts ner ochCytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. Roquinimex, the lead compound, was found to be metabolised by CYPs to hydroxylated and demethylated metabolites. A similar metabolite patter

Different aspects of cantilevers to be used as sensors have been studied. Silicon cantilevers have been fabricated and integrated on CMOS chips using low-energy electron beam lithography in order to reduce the irradiation damage to the circuits. The released and integrated cantilevers have been tested and used as mass sensors in air. The resonance frequency of the cantilever was measured before an

BACKGROUND: In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. We have also developed an ex-vivo system of assessing the function of such organs before transplantation. The next stage was to try the technique in human beings. Bearing in mind the sensitive ethical issues involved, our first aim was to find out what procedures would be ac

The 7-10 November 2004 period contains two events for which the local ground magnetic field was severely disturbed and simultaneously, the solar wind displayed several shocks and negative B-z periods. Using empirical models the 10-min RMS Delta X and Delta Y at Brorfelde (BFE, 11.67 degrees E, 55.63 degrees N), Denmark, are predicted. The models are recurrent neural networks with 10-min solar wind

Proteinase 3 (PR3) is a neutrophil serine protease stored in the azurophil granules of the promyelocyte and its successors. The protease has been identified as an autoantigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) occurring in patients with Wegener's granulomatosis. To characterize the biosynthesis and processing of human PR3 in a transgenic cellular model, cDNA encoding human pre-p

Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni

A follow-up study was performed to investigate the stability of IQ measures in a group of dyslexic teenagers and young adults. Earlier research had shown contradictory results. The 65 subjects, 12 years old on the average at first test, were retested after a mean interval of six and a half years. There was a significant relative decrease in verbal IQ (VIQ), which was interpreted as either an effec

This thesis contributes to the economic literature on prosocial behavior. It includes three papers, all of which relate to the issue of policy-driven spillovers across prosocial alternatives. For example, the common fundraising practice of donation matching could affect contributions through other channels; similarly, recycling policy could affect household efforts on other environmental activitie

Synopsis In methanol solutions of Zeise's salt, the parent complex [PtCl3(C2H4)]- as well as its solvolysis product, trans-[PtCl2(C2H4)(MeOH)], exchange rapidly with free ethene. The olefin exchange process, which is largely entropy controlled, involves the substitution labile site trans to the coordinated ethene. Abstract Complex equilibria in methanol/chloroform/dichloromethane solutions contain

Post Conflict Futures is an ongoing project, where displaced Syrian academics meet in Visioning Labs and a global scenario group to jointly reflect on possible future developments and to look for actionable leverage points to work proactively for sustainable transitions. The collective visioning aims to identify aspects that may be critical in strategies for sustainable post conflict reconstructio

Mandibular autopsy specimens were examined with different radiographic techniques in order to evaluate the visibility of the mandibular canal and the measurement accuracy of distances related to the mandibular canal. Hypocycloidal, spiral and computed tomography (CT) were superior to periapical and panoramic radiography in visualising the mandibular canal. The tomographic techniques were more accu

This report is a master thesis in Mechanical Engineering at the Faculty of Engineering LTH at Lund University. The project was performed in collaboration with ASSA ABLOY Entrance Systems, a Swedish company founded in 1994 manufacturing manual and automatic entrance systems. ASSA ABLOY Entrance Systems is one of five divisions at ASSA ABLOY which is one of the largest companies within the field of

Det nu gällande EU-rättsliga regelverket som reglerar skyddet för personuppgifter är dataskyddsdirektivet. En ny dataskyddsförordning som kommer träda i kraft i maj 2018 har emellertid antagits. En särskild fråga som också utgör huvudföremålet för denna uppsats är frågan om dataskyddsreglernas extraterritoriella tillämpningsområde. Uppsatsen syftar således till att utreda dataskyddsreglernas extThe EU data protection law aims at protecting personal data as they are subject to data processing by various actors. The current EU law governing data processing is the Data Protection Directive (DPD). During the past few years the EU data protection law has undergone a reform that ultimately led to the adaption of the General Data Protection Regulation (GDPR). The GDPR will come into force as of

Models for dynamic simulation of a parabolic trough concentrating solar power plant were developed in Modelica for the simulation software Dymola. The parabolic trough power plant has a two-­‐tank indirect thermal storage with solar salt for the ability to dispatch electric power later in the evening and during the night when little or no solar irradiation is present. The complete system consists

In the fifth generation of mobile communication, 5G, frequencies above 30 GHz, so-called millimeter-wave (mm-wave) frequencies are expected to play a prominent role. For the synthesis of these frequencies, the all-digital phase locked loop (ADPLL) has recently gained much attention. A core component of the ADPLL is the digitally controlled oscillator (DCO), an oscillator that tunes the frequency d