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Of increasing interest in the field of protein modelling and simulation is the effects of crowding. In a living cell, large molecules can take up 30% of the cell plasma volume, and affects the folding and dynamics of proteins. Computer simulations have so far focused mainly on simple spherical crowders, but recent simulations with protein crowders have shown effects beyond what can be replicated u
Populärvetenskaplig sammanfattning: Under slutet på juraperioden och början på kritaperioden såg vår del av världen helt anorlunda ut. Nordamerika låg sammanslaget med Europa och Atlanten hade ännu inte skapats. De enorma krafter som rör sig inne jorden, och ger upphov till jordbävningar och vulkanutbrott, hade dock börjat verka för att separera kontinenterna. Stora sprickor i jordskorpan började On the footwall side of the Coffee Soil Fault in the Danish Central Graben, five potential petroleum reservoir structures were distinguished on seismic images. The deposits were formed during the Late Jurassic-Early Cretaceous transition. South of these structures coarse clastic sediments of Late Jurassic to Early Cretaceous age, interpreted as submarine fans, have been drilled in a few wells. To
The meaning of the concept of psychosocial treatment is ambiguous. The purpose of this study was to examine how professionals within some care institutions, which provide methadone, buprenorphine or naloxone treatment, regard and carry out the psychosocial features of such treatment. Central issues discussed were; how personnel approach the psychosocial features of the treatment, what personnel re
In order to suggest improvements for the logistics of STARKA, we felt that we had to analyze all the activities which were related to STARKA's logistic processes. Our primary analysis consisted of a rough but comprehensive description of different functions in the company, and the relationship between them. This was performed by following a typical order through the company to see which functi
Uppsatsen syftar till att förklara varför svenska lagstiftare fastställde de rådande gränsvärdena för revisionsplikt genom att identifiera vilka intressegrupper och faktorer som kan tänkas ha påverkat beslutet. Vi gjorde en kvalitativ studie över lagändringsprocessen, SOU 2008:32. Vidare använde vi en induktiv forskningsansats vid analys av de offentliga statliga dokumenten samt remissyttranden. U
Big Data has experienced recent developments in the field of Business Intelligence and has captured the increasing interest of enterprises who are trying to seize its potential. More and more companies, operating in industries ranging from insurance to the entertainment industry, are moving forward with the adoption of Big Data, in an attempt to gain significant benefits, such as customer insight,
Popular Abstract in Swedish Klumpfot är en medfödd fotfelställning, som drabbar 1 av 1000 barn. Behandlingen består initialt av korrektion av felställningen, genom töjning och eventuellt operation. Det finns flera alternativa metoder att genomföra töjningar, och flera alternativa operationsmetoder. När felställningen korrigerats övergår behandlingen till att bibehålla det uppnådda läget med hjälp Clubfoot is a congenital disorder, affecting about one of 1000 children. Treatment consists of initial correction of the deformity, followed by prolonged orthosis treatment to maintain the correction obtained. There are several different treatment options. Outcome studies, using reliable and valid instruments are rare. In this thesis an assessment instrument, Clubfoot Assessment Protocol (CAP) wa
We invited 1604 randomly selected women, all 75 years of age, to participate in a study on the risk factors for fracture. The women were divided into three groups consisting of 1044 (65%) who attended the complete study, 308 (19%) respondents to the study questionnaire only and 252 (16%) who did not respond. The occurrence of the life-time fracture was ascertained from radiological records in all
Eucalyptus plantations have been established in many areas of the world due to their fast growth and profitability. In NW Spain, Eucalyptus plantations now cover a larger area than native forests. Although Eucalyptus plantations have been shown to affect biodiversity, relatively few studies have compared their effect on multiple taxonomic groups and different aspects of biodiversity. We compared h
The effect of age on ICA and thyrogastric antibodies at diagnosis of IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15-34 yr and in 282 volunteers of the same age. ICAs were present in 61% (383 of 633) of the patients and in 2% (5 of 282) of control subjects. When the initial classification was considered, ICAs were detected in 69% (327 of 473) of patients with ID
The dynamics of insulin and chromium release from prelabelled rat pancreatic islet cells were studied by perifusion of cells supported in a column of Bio-Gel P-2 polyacrylamide beads. The column-perifused β cells released insulin in a biphasic pattern in response to 30 mmol/l D-glucose and in a monophasic pattern to 20 mmol/l L-arginine. Rat islet cells, first exposed
Tissue transglutaminase (tTG) and microbial transglutaminase (mTG) cross-link gliadins to form complexes that expose immunogenic neo-epitopes to produce tTG and mTG-neo-epitope antibodies. The aim of this study was to test the diagnostic performance of antibodies against non-complexed and complexed forms of transglutaminases, to correlate their activities to the intestinal damage and to explore ag
BACKGROUND: Brain derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was implicated with microcirculatory ischemia and may reflect cardiomyocyte injury. We aimed to determine whether prospective changes (%Δ) in BDNF and cardiac troponin T (cTnT) will be associated with executive cognitive function in a bi-ethnic coho
In the fields of medicine and biology, the separation of particles is a central step in many preparative and analytical processes. Deterministic Lateral Displacement (DLD) has been a promising technique in the field of microfluidic particle and cell sorting, specifically for label-free separation with several applications of sorting by size, morphology, and deformation reported in the literature o
Objectives: This study sought to examine the relationship between temperature at reperfusion and infarct size. Background: Hypothermia consistently reduces infarct size when administered prior to reperfusion in animal studies, however, clinical results have been inconsistent. Methods: We performed a patient-level pooled analysis from six randomized control trials of endovascular cooling during pri
The process of cutting is treated as a fracture mechanical process. For an elliptic rigid wedge pressed into an elastic material, fracture may occur as an autonomous process if the tip of the wedge is sufficiently blunt or is affected by the geometry of the wedge if the tip is sharp. The conditions leading to the former or the latter case is obtained as a relation between the wedge tip radius, the
BACKGROUND: Several major analyses have identified a consistent set of independent risk factors for cutaneous malignant melanoma (CMM). A few prognostic models have been presented but some are based on a limited number of patients and others are based on selected groups of patients referred to major institutions. No nationwide population-based prognostic instrument for survival of CMM has been pre
Objectives: The overall aim of the Swedish Breast Reconstruction Outcome Study was to investigate national long-term outcomes after mastectomy with or without breast reconstruction. The current report evaluates breast reconstruction (BR) patterns in Sweden over time. Materials and methods: This is a cross-sectional, registry-based study where all women operated with mastectomy 2000, 2005, 2010 wer
