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Induced pluripotent stem cells (iPSCs) generated from somatic cells of patients can be used to model different human diseases. They may also serve as sources of transplantable cells that can be used in novel cell therapies. Here, we analyzed neuronal properties of an iPSC line derived from a patient with a juvenile form of Huntington's disease (HD) carrying 72 CAG repeats (HD-iPSC). Although its i
Members of the bone morphogenetic protein-1/tolloid (BMP-1/Tld) family of metalloproteinases, also known as procollagen C-proteinases (PCPs), control multiple biological events ( including matrix assembly, cross-linking, cell adhesion/migration and pattern formation) through enzymatic processing of several extracellular substrates. PCP activities on fibrillar procollagens can be stimulated by anot
A sensitive method for the detection of staphylococcal enterotoxin B (SEB) using a flow-injection capacitive biosensor is presented. SEB was purified from a crude culture filtrate of Staphylococcus aureus through three chromatographic steps. The first two steps were based on ion-exchange chromatography, and the last step was carried out on a gel filtration column. The SEB recovery values after the
In this study linear free energy relationships (LFER) are applied to the relaxation of core-excited states in aliphatic CH3X compounds. There are at least two valence orbitals involved in Auger decay following C-CH3 1s -> sigma*(C-X) excitation, which may as well be localized on the substituents in this series. Therefore, the observed property cannot be strictly attached to the so-called reaction
The implementation of gender fair language is often associated with negative reactions and hostile attacks on people who propose a change. This was also the case in Sweden in 2012 when a third gender-neutral pronoun hen was proposed as an addition to the already existing Swedish pronouns for she (hon) and he (han). The pronoun hen can be used both generically, when gender is unknown or irrelevant,
The purpose of this study is to describe how the energy efficiency and greenhouse gas (GHG) benefits of ethanol depend on local conditions and calculation methods. The following four parameters have been identified as crucial to the GHG benefits of ethanol: (i) energy efficiency and emissions of nitrous oxide during cultivation, (ii) what kind of fuel is used in ethanol plants, (iii) how efficient
Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni
Experimental data obtained in this study (Part II) complement the speciation data presented in Part I, but also offer a basis for extensive facility cross-comparisons for both experimental ignition delay time (IDT) and laminar flame speed (LFS) observables. To improve our understanding of the ignition characteristics of propene, a series of IDT experiments were performed in six different shock tub
Transverse momentum spectra of pi(+/-), K-+/- and p((p) over bar) up to p(T) = 20 GeV/c at mid-rapidity in pp, peripheral (60-80%) and central (0-5%) Pb-Pb collisions at v root s(NN) = 2.76 TeV have been measured using the ALICE detector at the Large Hadron Collider. The proton-to-pion and the kaon-to-pionratios both show a distinct peak at p(T) approximate to 3 GeV/c in central Pb-Pb collisions.
During the last twenty years archaeology has experienced a technological revolution that spans scientific achieve-ments and day-to-day practices. The tools and methods from this digital change have also strongly impacted archaeology. Image-based 3D modeling is becoming more common when documenting archaeological features but is still not implement-ed as standard in field excavation projects. When
The production of space contains an antagonism between a use-value relation and an exchange-value relation. In this paper these categories are used to analyse two empirical cases from Bergen, Norway. The first case concerns a public debate in 2005, about whether Clear Channel should be allowed to install advertising boards in the city. The second case concerns a debate in 2007, about whether Berge
Behovet av klimatreglering har ökat kraftigt sedan 1960-talet. Ett av skälen till detta är den ändrade byggtekníken, som innebär lättare konstruktioner med större inre värmebelastning från belysning, maskiner, personer och solinstrålning genom stora fönsterytor. De ökade värmebelastningarna kan klaras av med ett flertal olika klimatsystem. Dessa system kräver någon form av reglering. Under 1970-taResults from a research project supported by the Swedish Council for Building Research are reported. The main task was to improve climate control technology. The work was focused on digital control. It was split up into three main tasks: model building, design of regulators, and fullscale experiments. Several rooms, airducts, and heat exchangers were modelled. Simple dynamic models have been deriv
Digital image correlation (DIC) can measure full-field surface strains during mechanical testing of hard and soft tissues. When compared to traditional methods, such as strain gauges, DIC offers larger validation data (similar to 50,000 points) for, e.g., finite element models. Our main aim was to evaluate the repeatability of surface strain measurements with DIC during compressive testing of comp
The global company operates from a number of locations worldwide, resulting in implications for the transport, handling and storage of product and parts transported within the company as well as between the company divisions and suppliers and/or consumers. In these companies, the package becomes a frequently used object to complement product features and achieve an effective and efficient means of
Popular Abstract in Swedish De senaste årens framsteg inom bioteknologin har medfört att det utvecklas allt fler proteinbaserade läkemedel. Detta innebär att vi har fått bättre mediciner mot allvarliga sjukdomar, men tyvärr måste proteiner nästan alltid tas med spruta, och ofta krävs långa behandlingar med dagliga injektioner. Det finns även andra grupper av läkemedelssubstanser som ökar i omfattnControlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. In order to be able to control the release rate, it is vital to know the underlying release mechanisms. A novel method for measuring the diff
This article deals with an archaeology of Reformation in medieval Denmark. The change from Catholic to Protestant confession, which took place in 1536, ha,,; not been subject to elaborate investigation by archaeologists. The main question is, whether material culture reflects differences in the lifestyle between people possessing a Catholic or Protestant belief The focus is to find out how the dif
Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are mature CD5(+) B-cell malignancies with different biological/clinical characteristics. We recently reported an association between different prognostic subgroups of CLL (i.e., IGHV mutated and unmutated) and genomic methylation pattern. However, the relationship between DNA methylation and prognostic markers, such as the prolifer
Introduction: This research sought to extend knowledge about bystanders in bullying situations with a focus on the motivations that lead them to different responses. The 2 primary goals of this study were to investigate the reasons for children's decisions to help or not to help a victim when witnessing bullying, and to generate a grounded theory (or conceptual framework) of bystander motivation i
A new mu-oxo diiron(III) complex of the lithium salt of the pyridine-based unsymmetrical ligand 3-[(3-{[bis(pyridin-2-ylmethyl)amino]methyl}-2-hydroxy-5-methylbenzyl)(pyridin2-ylmethyl)amino] propanoate (LiDPCPMPP), [Fe-2(mu-O)(LiDPCPMPP)(2)](ClO4)(2), has been synthesized and characterized. The ability of the complex to catalyze oxidation of several alkanes and alkenes has been investigated by us
