Filetype
IMPORTANCE The positron emission tomography (PET) tracer [18F]flortaucipir allows in vivo quantification of paired helical filament tau, a core neuropathological feature of Alzheimer disease (AD), but its diagnostic utility is unclear. OBJECTIVE To examine the discriminative accuracy of [18F]flortaucipir for AD vs non-AD neurodegenerative disorders. DESIGN, SETTING, AND PARTICIPANTS In this cross-
Purpose: The aim of this study was to investigate people’s experiences of living with dysphagia after stroke, and their experiences of dysphagia management. Methods: The study design was qualitative, and an open-ended approach to data collection was used, with follow-up probing questions to gain more information as needed. Personal interviews were conducted with five persons who had persisting mod
When discussing the relationship between religion and LGBTQIA+ rights in Europe today, the two are often framed by both religious and secular representatives as oppositional forces. While the rights of sexual and gender minorities are frequently described as symbols of progress and modernity within liberal democracies, religious communities and traditions are commonly portrayed as defenders of tra
Background: Win statistics offer an alternative approach to clinical trials that use survival analysis to analyze composite endpoints. Our objective was to re-analyze data from previously published registry-based randomized controlled trials that produced hazard ratios using win statistics to evaluate the correspondence between them. Good correspondence was defined as both results being positive,
Populärvetenskaplig sammanfattning: Den ökande växthuseffekten, med påföljande klimatförändringar, framträder alltmer som ett av vår tids största miljöproblem. På grund av människans industriella och agrikulturella aktiviteter har atmosfärskoncentrationen av de viktiga växthusgaserna koldioxid (CO2), metan (CH4) och lustgas (N2O) ökat drastiskt. Med hjälp av modeller och beräkningar förutspås det Northern peatlands are important in the context of the climate change. Since they comprise huge amounts of soil organic carbon and are found where the most significant greenhouse warming is predicted, they have the potential to exert major feedback effects on the global warming. Studies of the greenhouse gas exchange in northern peatlands have mainly focused on the growing season when the soil is
Because corporations trade on the international markets and the governments regulate on domestic markets, conflicts between government regulations are difficult to avoid. Several authors have introduced different ways to avoid this type of conflict. One alternative, which is also proposed by the EU Commissioner Monti, is the inclusion of minimum regulation in the World Trade Organization, by which
Clinical and radiographic data provide important information in the evaluation of soft tissue lesions/neoplasms. Morphologic tissue and cytologic examination is considered to be a necessary part of the diagnostic work-up. The standard procedure for obtaining tumor tissue for morphologic evaluation has been incisional (open) or core needle biopsy. An increasing use of minimally invasive diagnostic
Mineralogical and geochemical studies of the non-marine Permian–Triassic (P–Tr) boundary across two stratigraphically wellconstrained sections (Commando Drift Dam and Wapadsberg, Eastern Cape Province) in the southern Karoo Basin, South Africa, have been undertaken to provide further input on the cause of this mass extinction event, and so has a sedimentological and geochemical evaluation of a thi
BACKGROUND: The use of nitrous oxide (N2O) during hemodilution has been questioned. Nitrous oxide reduces the inspired oxygen fraction (F1O2), depresses myocardial function and may reduce cardiac output (CO) and systemic oxygen delivery (DO2SY). The aim of this study was to evaluate the importance of the effects of nitrous oxide on systemic and myocardial circulation and oxygenation during extreme
In this thesis, I have studied male and female selective mechanisms that can affect plant reproductive success and gene flow. I have focussed on sexually selected traits, mainly pollen competition and maternal sorting mechanisms, for example through non-random ovule abortion. The main question was; what kind of traits can influence the most successful pollen donor or maternal sorting process? I fo
The theme of men and women is conspicuous in T. S. Eliot's early poetry. It constitutes the subject of this study, which is an investigation of the symbolic images, metaphors and similes associated with this theme. When a man/woman relationship is referred to, the relevant imagery is often taken from historical or mythical narratives, suggesting an element of universal applicability. Painful feeli
How we initially formulate our decision problems may have a strong influence on our decisions and we often take the presented problems and alternatives for granted. When facing difficult decisions it is important to consider things as: ”am I considering the right decision”, ”are there other decisions with other alternatives that are more relevant”, etc. Also when considering a previously made deci
Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.
A longitudinal research project began in 1993 of Norwegian, Swedish and American mothers' perception of her family's dynamics and adaptation during childbearing and childrearing. Results indicated that Swedish mothers adapted better than other mothers. In 2003, a mixed design study was conducted with original Swedish mothers that aimed to describe the experience of motherhood, the meaning mothers
Liquefaction of human semen involves proteolytic degradation of the seminal coagulum and release of motile spermatozoa. Several members of human kallikrein-related peptidases (KLKs) have been implicated in semen liquefaction, functioning through highly regulated proteolytic cascades. Among these, KLK3 (also known as prostate-specific antigen) is the main executor enzyme responsible for processing
BACKGROUND: In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. We have also developed an ex-vivo system of assessing the function of such organs before transplantation. The next stage was to try the technique in human beings. Bearing in mind the sensitive ethical issues involved, our first aim was to find out what procedures would be ac
OBJECTIVE: To study the pharmacodynamics of amoxicillin/clavulanic acid against different strains of Haemophilus influenzae in an in vitro kinetic model. The concentrations used corresponded to human serum levels obtained after 875 mg amoxicillin/clavulanic acid given b.i.d., 500/125 mg amoxicillin/clavulanic acid given t.i.d. and those obtained with a pharmacokinetically enhanced formulation cont
The paranormal has gone mainstream. Beliefs are on the rise, with almost half of the British population, and two thirds of Americans, claiming to believe in extra sensory perceptions and hauntings. Psychic magazines like Spirit and Destiny, television shows such as Fringe, Ghost Whisperer and Most Haunted, ghost-cams and e-poltergeists, bestselling books on mind, body and spirit, and magicians li
Different aspects of cantilevers to be used as sensors have been studied. Silicon cantilevers have been fabricated and integrated on CMOS chips using low-energy electron beam lithography in order to reduce the irradiation damage to the circuits. The released and integrated cantilevers have been tested and used as mass sensors in air. The resonance frequency of the cantilever was measured before an
