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Antibody-dependent allostery of the M1 protein

Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands

Polygenic pathways shape white matter vulnerability to Alzheimer’s disease-related pathophysiological changes

Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei

Verksamhetsplan 2020 for ebsco systems nordic user group

Verksamhetsplan 2020 för EBSCO Systems Nordic User Group Antagen av styrelsen: 2020-05-14 Styrelsen ska under verksamhetsåret fortsätta arbetet med att komma med förslag på förbättringar i de EBSCO-system som gruppens medlemmar använder och att utveckla kontakten och samarbetet mellan bibliotek och organisationer kring desamma. För att vara en relevant användargrupp är styrelsen beroende av att me

https://www.ub.lu.se/sites/ub.lu.se/files/verksamhetsplan_2020_for_ebsco_systems_nordic_user_group.pdf - 2026-05-30

Sports Medicine Frontiers: Evidence-Based Strategies for Infection Control and Hip Health in athletes

2 februari 2026 16:00 till 18:00 | Föreläsning Welcome to an afternoon on sports medicine, featuring lectures by renowned international researchers, Professor Wayne Derman and Professor Joanne Kemp. Game On: Tackling infections in Sports with a Winning StrategyIn his talk, Wayne Derman will discuss how we in sports medicine often tend to focus on sports injuries rather than illnesses. Yet, several

https://www.medicin.lu.se/evenemang/sports-medicine-frontiers-evidence-based-strategies-infection-control-and-hip-health-athletes-0 - 2026-05-30

Sports Medicine Frontiers: Evidence-Based Strategies for Infection Control and Hip Health in athletes

2 februari 2026 16:00 till 18:00 | Föreläsning Welcome to an afternoon on sports medicine, featuring lectures by renowned international researchers, Professor Wayne Derman and Professor Joanne Kemp. Game On: Tackling infections in Sports with a Winning StrategyIn his talk, Wayne Derman will discuss how we in sports medicine often tend to focus on sports injuries rather than illnesses. Yet, several

https://www.lu.se/evenemang/sports-medicine-frontiers-evidence-based-strategies-infection-control-and-hip-health-athletes-0 - 2026-05-30

Sports Medicine Frontiers: Evidence-Based Strategies for Infection Control and Hip Health in athletes

2 februari 2026 16:00 till 18:00 | Föreläsning Welcome to an afternoon on sports medicine, featuring lectures by renowned international researchers, Professor Wayne Derman and Professor Joanne Kemp. Game On: Tackling infections in Sports with a Winning StrategyIn his talk, Wayne Derman will discuss how we in sports medicine often tend to focus on sports injuries rather than illnesses. Yet, several

https://www.medarbetarwebben.lu.se/evenemang/sports-medicine-frontiers-evidence-based-strategies-infection-control-and-hip-health-athletes-0 - 2026-05-30

Daniel Alfons

Studievägledare Kontaktinformation E-post: daniel [dot] alfons [at] svet [dot] lu [dot] se Telefon: +46 46 222 89 50Organisation Statsvetenskapliga institutionen Rumsnummer: 232 Hämtställe: 31 Idag arbetar jag till 50 procent som studievägledare och 50 procent som biträdande studierektor.StudievägledningRum: 232 Boka tid för samtal genom TimeEdit.Om du inte är student vid Lunds universitet vänlige

https://www.svet.lu.se/daniel-alfons - 2026-05-29

LU-gemensamt Mejlutskick Nr 20-v22-2021

NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 20 v 22 - 2021. UNIVERSITETSGEMENSAMT Lönerevisionen drar ut på tiden Förhandlingarna med anledning av lönerevisionen pågår fortfarande. Tyvärr kan det konstateras att det nu har dragit ut så långt i tiden at

https://www.cec.lu.se/sites/cec.lu.se/files/2021-06/LU-gemensamt%20Mejlutskick%20Nr%2020-v22-2021.pdf - 2026-05-30

Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency

Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat

The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses

Arsine, Stibine and Phosphine Derivatives of [Fe2(CO)6(μ-bdt)] (bdt = Benzenedithiolate) : Syntheses, Structures and Spectroscopic and Electrocatalytic Studies

The reactivity of the benzenedithiolate (bdt)-bridged complex [Fe2(CO)6(µ-bdt)] with arsine, stibine and phosphine ligands has been studied. The new mono- and disubstituted complexes [Fe2(CO)5(EPh3)(µ-bdt)] (E = As, 1; E = Sb 3) and [Fe2(CO)4(EPh3)2(µ-bdt)] (E = As, 2; E = Sb, 4) and the previously reported [Fe2(CO)4(PPh2H)2(µ-bdt)] (5) have been prepared by Me3NO-initiated carbonyl substitution r

The derivation of first- and second-order backpropagation methods for fully-connected and convolutional neural networks

We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela

Kliniska Vetenskaper, Helsingborg

Department of Clinical Sciences Lund/Clinical Sciences Helsingborg (Avdelningen Kliniska Vetenskaper Helsingborg, AKVH) was constituted when Helsingborg General Hospital became part of the Lund University Medical School program 2012. Today, a network of researchers from different specialties are affiliated to AKVH.