Filetype
Our main focus is understanding peripheral pathology in HD and investigate its importance for disease pathogenesis and biomarkers. Our work is based on the hypothesis that insights into peripheral pathology in HD will improve knowledge of key pathogenic mechanisms, possibly providing new biomarkers and novel therapeutic targets.
This thesis explores whether and how rural-to-urban migration alters the Chinese migrant family in the case of divided rural households of 10 male migrant workers. The study relied on in-depth semi-structured interviews with married men, who are fathers, husbands and sons, and who are currently working on construction sites in Beijing. Drawing on Lusher & Robins’(2009) theory of masculinity, t
This thesis investigates the key factors influencing startup decisions to reintegrate environmental sustainability objectives (ESO). By adopting an inductive and deductive qualitative approach the study uses semi-structured interviews to investigate the decisionmaking of five startups that have undergone ESO reintegration. The findings lead to the establishment of a theoretic framework by identify
Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. Recent studies have highlighted the relation of single nucleotide polymorphisms of ge
Besides their central function in respiration, plant mitochondria play a crucial role in maintaining cellular homeostasis during stress by providing "retrograde" feedback to the nucleus. Despite the growing understanding of this signaling network, the nature of the signals that initiate mitochondrial retrograde regulation (MRR) in plants remains unknown. Here, we investigated the dynamics and caus
Background: Smoking is an important preventable risk factor for cardiovascular disease, cancer, and many other diseases. Even though tobacco consumption is declining in Sweden, it is not declining in all groups. This study explored socioeconomic and psychosocial circumstances hindering or facilitating smoking cessation in three birth cohorts of women from the general population. Methods: Between 1
The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities of triacylglycerol lipases. In this study, we demonstrate that adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are the major enzymes contributing to TG breakdown in in vitro assays and in organ cultures of murine white adipose tissue (WAT). To differentiate between ATGL- and
While much has been written about how startups work to develop their product, this paper focuses instead on how to manage the startup team. Based on a systematic review of current research, I present actionable insights about startup team characteristics; who they are, how they work, and how they stay together. I explain how these characteristics imply both opportunities and threats for the viabil
Vår forskning fokuserar på personer med allvarlig och långvarig psykisk sjukdom och deras livssituation i samhället. De omfattande omstruktureringarna av det psykiatriska vård- och stödsystemet har inneburit långtgående krav på en utveckling av nya kunskapsbaserade vård- och stödinsatser. Detta för att främja hälsa och ett meningsfullt liv i samhället för den här gruppen och deras anhöriga. Många Our research focuses on individuals with severe and long-lasting mental illness and their situation in society. The extensive restructuring of the mental health and support systems towards community-based service systems brings forth far-reaching requirements for developing new knowledge-based health and support interventions. Such efforts are needed to favour and support health and a meaningful l
Epilepsy is a devastating neurological disorder characterized by synchronous neuronal activity, which manifests as epileptic seizures. It usually develops after an initial insult, such as head trauma or stroke, which triggers the epileptogenic process. During epileptogenesis, the affected brain regions undergo multiple changes in connectivity and gene expression, and among the most affected genes
Avdelningen för molekylär hematologi omfattar idag tolv forskningsgrupper som alla studerar olika aspekter av blodcellers funktion vid hälsa och sjukdom. Genom hela livet utgår all blodbildning från så kallade blodstamceller som försörjer kroppen med miljarder blodkroppar varje dag. En normal balanserad produktion av blodkroppar via blodstamcellerna är avgörande för att vi skall hålla oss friska.Dysfunctional blood cell development can have fatal consequences on human health, with implications for several key areas of modern medicine, including amongst others the broad research areas of oncology and immunology. The Division of Molecular Hematology (DMH) aims to generate new knowledge about the regulation of blood cell development by applying recent advances in stem cell technology, in ord
Vår multidisciplinära forskning fokuserar på personer med neurodegenerativa sjukdomar (såsom Parkinsons sjukdom och kognitiva sjukdomar), inklusive personer som har en ökad risk att utveckla sådana sjukdomar. En tidig upptäckt möjliggör tidigt stöd och rehabilitering. Vår forskning identifierar tidiga tecken, konsekvenser, prognostiska faktorer och behov av åtgärder. Forskningen avser även att ökOur multidisciplinary research focus on people with neurodegenerative diseases (ND), such as Parkinson’s disease and major neurocognitive disorders (dementia). We also include people at risk of developing ND. Early detection facilitates timely support and rehabilitation. Our research aims to determine early signs, consequences, unmet needs, and prognostic factors. We also aim to gain an increased
I världen lider flera 100 miljoner människor av autoimmuna sjukdomar och de är ett folkhälsoproblem i paritet med cancer och hjärt/kärlsjukdomar. Vi har fokuserat vår forskning kring en grupp ovanliga men allvarliga autoimmuna sjukdomar, ANCA associerade vaskuliter. Sjukdomarna orsakar en akut inflammation i de små blodkärlen, vilket leder till en snabbt förlöpande glomerulonefrit och livshotande Autoimmune diseases affect several 100 million people world wide and is a tremendous public health problem comparable with heart disease and cancer. We have focused our research to a group of severe autoimmune diseases, called ANCA (anti-neutrophil cytoplasmic antibody) associated systemic vasculitis. The diseases present with acute inflammation in the small vessels and cause rapidly progressive r
The field of research is to uncover the genetic and environmental etiology of autoimmune (type 1) diabetes, celiac disease as well as narcolepsy. The genetics of the disease is dissected also in the spontaneously diabetic BB rat. Specific autoantibody markers are used to predict the clinical onset of diabetes or celiac disease. Longitudinal studies of children at increased risk allow studies of t
