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BACKGROUND: Palliative sedation is used to relieve refractory symptoms and is part of clinical practice in Sweden. Yet we do not know how frequently this practice occurs, how decision-making takes place, or even which medications are preferentially used.OBJECTIVES: To understand the current practice of palliative sedation in Sweden.METHODS: We conducted a retrospective cross-sectional medical reco
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,
Optical imaging utilize light to analyze biological tissues in detail, non-invasively and without harmful radiation. Examples include ultrasound optical tomography and photoacoustic imaging; both use a limited number of wavelengths. Diffuse reflectance spectroscopy, another optical technique, covers a continuous wavelength range, but without generating an image. This study focuses on extended-wave
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated Dose Toxicity was determined using read across analog to have the mos
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic e
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic e
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have
