Filetype
Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari
Purpose of review Breathlessness is a common, distressing and limiting symptom in people with advanced disease, but is challenging to assess as the symptom intensity depends on the level of exertion (symptom stimulus) during the assessment. This review outlines how to use recently developed normative reference equations to evaluate breathlessness responses, accounting for level of exertion, for va
Frågan om alkohol- och drogtester på arbetsplatser har blivit en alltmer framträdande och komplex fråga. Med en betydande ökning av sådana tester under de senaste åren har debatten om balansen mellan kontroll och personlig integritet intensifierats. Å ena sidan söker arbetsgivare att minimera risker associerade med alkohol- och droganvändning genom att skapa en säker och drogfri arbetsmiljö. Å andThe issue of alcohol and drug testing in the workplace has become an increasingly prominent and complex issue. With an increase in such tests in recent years, the debate about the balance between control and privacy has intensified. On the one hand, employers seek to minimize risks associated with alcohol and drug use by creating a safe and drug-free work environment. On the other hand, workers fa
NJA 2015 s. 702, ofta kallat Balkongmålet, har under åren väckt stor uppmärksamhet till följd av fallets introduktion av en ny bevisprövningsmetod. Modellen har kommit att kallas ”Balkongmetoden” och innebär att domstolen i första hand tar hänsyn till bevisningen till stöd för gärningsbeskrivningen. Bara i de fall åklagarens bevisning i sig uppnår beviskravet vägs denna mot bevisningen som talar tEver since the ‘Balcony case’ introduced a new way of evaluating evidence, the method has been a subject of debate. The evaluation model, known as the ‘Balcony method’, offers a step-by-step structure that initially reviews the evidence presented by the prosecutor. Only if this evidence independently meets the evidentiary requirement may the court continue to the next step of the evaluation and ta
Objective: The purpose of the study was to examine associations between self-esteem and symptoms of anxiety and depression among young adults who lost a parent to cancer. Methods: Older adolescents and young adults, aged 16 to 28 years, who had lost their parent to cancer and had accepted an invitation to join a support group, completed a questionnaire 5 to 8 months after the loss and a similar qu
Breathlessness is common in the general population. Existing data were obtained primarily with the uni-dimensional modified Medical Research Council breathlessness scale (mMRC) that does not assess intensities of unpleasantness nor physical, emotional and affective dimensions. The aim of this research was to determine the prevalence and intensity of these dimensions of breathlessness in elderly ma
This paper contains a quantification and decision theoretical optimization of the posterior utilities for several options for monitoring campaigns on the particular case of fatigue life predictions of an orthotropic steel deck. The monitoring campaigns are defined by varying monitoring durations and phases. The decision analysis is performed with real data from the Structural Health Monitoring (SH
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., br
BACKGROUND: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.METHODS: This was a longitudinal, population
Phase contrast micro-CT is a powerful technique allowing imaging of soft tissue at synchrotrons or using lab- oratory sources. The use of contrast agents is a useful approach when imaging vascular structures. However, common x-ray contrast agents typically rely on heavy metals to increase absorption, which may affect the phase contrast and cause artifacts in the reconstructed volumes. Thus, utiliz
This study reports an impact evaluation carried out for a large-scale research infrastructure, the Brazilian Sirius Synchrotron Light Source, one of two fourth-generation synchrotron light sources in the world. We focus on the economic impacts and spillovers resulting from highly qualified procurements presented to different types of suppliers who participated in the design and construction proces
The concept of an innovation system is used to understand how innovation contributes to economic growth. However, innovation systems do not evolve evenly in different parts of the world. This paper contributes to the ongoing debate on the emergence of innovation systems in the context of developing countries. It uses the Rwandan case, where agriculture is a dominant socio-economic sector with high
Många som är aktiva i samhällsdebatten vittnar om ett hårdnande klimat och en rad ordförande i olika civilsamhällesorganisationer har avgått under de senaste åren efter att ha blivit hotade och kränkta på olika sätt, vilket har uppmärksammats i media. Kunskapen om hat, hot och kränkningar mot ledare i civilsamhället är dock begränsad, både internationellt och i Sverige. Syftet med artikeln är att
Background: The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional.Method: An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diag
In this paper, I briefly present my doctoral thesis research proposal. Recognizing that information has long been an important asset for any organization, I wish to explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Additionally, this research proposal emerges out of recognition that the academic library is a dynam
Many scholars and philosophers inspired by Antiquity, have commented upon a transformation of lived religion and a changing picture and technology of the Self during Late Antiquity. The Nag Hammadi Library contains a diverse body of thought and it is here argued that these texts are found in the epicentre of Late Antique conversion of religion and Self, containing important illustrations of new em
Popular Abstract in Swedish Introduktion Aggressivt antisocialt beteende utgör en stor utmaning för dagens samhälle, och undersökningar av vad som ligger bakom ett återkommande sådant beteende behövs för utvecklingen av våldspreventiva insatser. Syften & Metod Syftet med avhandlingen var att identifiera faktorer som samvarierar med återkommande aggressivt antisocialt beteende. De specifika måIntroduction Aggressive antisocial behavior is a major challenge to society, and studies on the determinants of its persistence are essential to the development of strategies to prevent violence. Aims & Methods The overall aim of the thesis was to establish covariates of persistent aggressive antisocial behavior in a population-based cohort and in clinically evaluated, prospectively followed,
When a country liberalizes trade through lowering taxes on imports, it stands before a number of challenges. Recovering lost trade tax revenue is one of them. Cape Verde is one of the countries that are currently negotiating an Economic Partnership Agreement with the EU and studies predict that the tariff reductions resulting from the agreement may have a severe impact on Cape Verde’s government r
Design är ett viktigt konkurrensmedel och till viss del ett styrmedel inom affärslivet, vilket blir allt viktigare i en ökad konkurrens på marknaden. Att vara unik som företag är en tillgång och ett företag som utvecklar och säljer designprodukter som ligger i framkant, med det följer framgång och tillväxt. När den ekonomiska betydelsen av design ökar så öppnar det upp ett intresse för konkurrenteDesign is an important competitive tool and to some extent a management tool in business, which is significant in the increasing competition on the market. Being unique as a company is an asset. A company that develops and sells design products that are at the front edge is probably heading for growth. When the economic importance of design increases, it opens up an interest for competitors who se
