Filetype
PURPOSE: The first interim analysis of the phase III, randomized, placebo-controlled TITAN study showed that apalutamide significantly improved overall survival (OS) and radiographic progression-free survival in patients with metastatic castration-sensitive prostate cancer (mCSPC) receiving ongoing androgen deprivation therapy (ADT). Herein, we report final efficacy and safety results after unblin
Purpose -The purpose of this paper is to investigate the added value of using temperature-dependent electric and magnetic properties in high-Temperature electromagnetic simulations. Design/methodology/approach - In this work, the electromagnetic properties of Domex 420, SSAB, have been characterized as a function of the temperature, from room temperature to 900°C. The measurement of the electric a
Treatment with anti-CD20 antibodies is only moderately efficient in chronic lymphocytic leukemia (CLL), a feature which has been explained by the inherently low CD20 expression in CLL. It has been shown that CD20 is epigenetically regulated and that histone deacetylase inhibitors (HDACis) can increase CD20 expression in vitro in CLL. To assess whether HDACis can upregulate CD20 also in vivo in CLL
PURPOSE: To prospectively examine the association between clonal hematopoiesis (CH) and subsequent risk of lung cancer. METHODS: Among 200,629 UK Biobank (UKBB) participants with whole-exome sequencing, CH was identified in a nested case-control study of 832 incident lung cancer cases and 3,951 controls (2006-2019) matched on age and year at blood draw, sex, race, and smoking status. A similar nes
PURPOSE: The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of this study was to explore associations between physical activity and sedentary time, measured by accelerometer, and autonomic function, using DBT.METHODS: In the Swedish Cardio-Pulmonary bioImage Study, men and women aged 50-64 were randomly invited from the general population. A total of 4325 subjects w
Rapport från ett seminarium sept. 2014 i Manama i Zimbabwe, om diakonens identitet i Lutherska kyrkan i Zimbabwe och i Sverige, två år efter den första vigningen (ordinationen) av diakoner i Evangelical Lutheran Church in Zombabwe.Report from a seminar i Manama in Zimbabwe September 2014: "The Identity of the Deacon in Zimbabwe and Sweden", two years after the first ordination of deacons in the Evangelical Lutheran Church in Zimbabwe (ELCZ).
Family caregivers in cancer and palliative care often face heavy responsibilities and feel insufficiently prepared for the situation as caregivers. This study evaluates short-term and long-term effects of a psycho-educational group intervention aiming to increase preparedness for family caregiving in specialized palliative home care.
Background Previous population-based studies suggest an increased risk of suicide in Parkinson’s disease (PD), but findings have been inconsistent and often limited by residual confounding. We examined the association between incident PD and suicide-related outcomes using extensive confounding control, including both suicidal attempts and suicide.Methods We conducted a nationwide matched cohort stBackground Previous population-based studies suggest an increased risk of suicide in Parkinson’s disease (PD), but findings have been inconsistent and often limited by residual confounding. We examined the association between incident PD and suicide-related outcomes using extensive confounding control, including both suicidal attempts and suicide.Methods We conducted a nationwide matched cohort st
Many seriously ill and frail older people experience a lack of practical support and meaningful social engagement. While healthcare provides good medical support, it lacks the full competence and resources to help with social, practical and existential challenges that can arise near the end-of-life. Increasingly, resources in civil society are enlisted to fill this care gap. One such attempt to br
CONTEXT: As part of a broader institutional initiative, the serious illness care program was implemented in a multi-site academic primary care practice. After 2 years, a minority was observed to be documenting serious illness conversations routinely.OBJECTIVES: We aimed to learn about the motivations and actions of clinicians who routinely conducted and documented serious illness conversations.MET
In almost all countries in the Middle East and North Africa (MENA) region, power sectors are characterized by a high degree of vertical integration and state control. However, several countries have undertaken reforms in order to open up the power market for private sector involvement particularly in relation to renewable energy (RE) sourced electricity generation. The majority of the MENA countri
Although capacity development has been a key aspect of global aid policy for decades, success is limited. Capacity development is defined as a process, based on a partnership, to develop capacity to achieve a goal. The purpose of this thesis is to increase our understanding of why capacity development does not work as intended, and to inform the discussion on addressing the challenges. Two researc
