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Objective. New proposed definitions of chronic kidney disease necessitate the development and use of simple and accurate methods for estimating glomerular filtration rate (GFR). Plasma cystatin C has been shown to be a more reliable GFR marker than creatinine and formulae for estimating GFR have been reported. The purpose of this study was to validate a cystatin C-based GFR prediction equation in
Background. Randomized trials have shown that icodextrin reduces the volume of extra-cellular fluid (ECFv) with variable effects on residual renal function. To explore this fluid shift and its possible mechanisms in more detail, prospectively collected data from one such trial, including measures of inflammation (C-reactive protein, tumor necrosis factor-a, albumin and low and high molecular weigh
Parkinson’s Disease (PD) is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements.Currently there is no cure for PD and the available drug treatments only offer symptomatic relief and are often associated with severe side
Background: Since barrier protection measures to avoid contact with allergens are being increasingly developed, we assessed the clinical efficacy and tolerability of a topical nasal microemulsion made of glycerol esters in patients with allergic rhinitis. Methods: Randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial in which adult patients with allergic r
A search is presented for a narrow resonance decaying to a pair of Z bosons using data corresponding to 1.02 fb(-1) of integrated luminosity collected by the ATLAS experiment from pp collisions at root s= 7 TeV. Events containing either four charged leptons (llll) or two charged leptons and two jets (lljj) are analyzed and found to be consistent with the Standard Model background expectation. Lowe
According to many scholars America's soft power is in decline, a power resource whose importance has been increasing in world politics. This makes it interesting to examine if there is a difference between how Democratic and Republican administrations wield their soft power. This thesis is a hypothesis-testing study and the purpose is to test the hypothesis that Democratic administrations, to
This thesis is a case study of a Spanish castle called Aljafería. The objective of the study was to develop the mediation of this particular castle and to construct a research design that could be used to develop the mediation of other architectural heritage visitor attractions. The research design emerged during the course of the case study, using a grounded method perspective. The most dominant
The ongoing Europeanisation is readily identifiable in our day-to-day life. Particularly in the field of law, the elaboration of a uniform and harmonised European private law is promoted and a truly European legal science is forced. Yet, comparative law and unification of law have concentrated on certain areas, which include mainly commercial law and related areas of civil law. The main issue of t
Populärvetenskaplig sammanfattning Morgondagens energi Vind-, och vattenkraft tillsammans med solenergi är de enda energikällorna vi har som inte leder till avfall som ökar växthuseffekt eller avfall som vi inte kan göra oss av (från t ex kärnkraftverk). Men solpanelerna som finns idag för kommersiellt privat bruk ligger på en effektivitet kring 15%. Att utveckla nya molekyler som kan omvanlda solThe aim of the study was to theoretically investigate if a proton coupled electron transfer (PCET) was feasible for a molecular system consisting of a light harvesting complex, ruthenium(tris-2,`2-bipy)2+, with different organic moieties serving as PCET (proton coupled electron transfer) relays. These light harvesting complexes are also sometimes referred to as dyes. By studying the energy levels
The International Bladder Cancer Group (IBCG) has proposed a prognostic model for intermediate risk (IR) non-muscle invasive bladder cancer (NMIBC) for clinical decision-making. We applied the IBCG IR model in a population-based Swedish setting in patients with primary IR NMIBC diagnosed 2013-2014 in BladderBaSe 2.0. Patients were stratified into low-risk (unifocal and tumour size < 3 cm) and inte
BACKGROUND: No practical tool quantitates the risk of circulatory-etiology death (CED) immediately after successful cardiopulmonary resuscitation in patients without ST-segment-elevation myocardial infarction. We developed and validated a prediction model to rapidly determine that risk and facilitate triage to individualized treatment pathways. METHODS: With the use of INTCAR (International Cardia
Eight different generations of dolerite dykes crosscutting the Paleoproterozoic basement in West Africa and one in South America were dated using the high precision U–Pb TIMS method on baddeleyite. Some of the individual dykes reach over 300Â km in length and they are considered parts of much larger systems of mafic dyke swarms representing the plumbing systems for large igneous provinces (LIPs).
Background: A pattern of major and minor congenital anomalies, facial dysmorphic features, and neurodevelopmental difficulties, including cognitive and social impairments has been reported in some children exposed to sodium valproate (VPA) during pregnancy. Recognition of the increased risks of in utero exposure to VPA for congenital malformations, and for the neurodevelopmental effects in particu
Class Ib ribonucleotide reductases (RNR) utilize a di-nuclear manganese or iron cofactor for reduction of superoxide or molecular oxygen, respectively. This generates a stable tyrosyl radical (Y·) in the R2 subunit (NrdF), which is further used for ribonucleotide reduction in the R1 subunit of RNR. Here, we report high-resolution crystal structures of Bacillus anthracis NrdF in the metal-free form
Objectives This study aimed to investigate the importance of potentially inappropriate medications, number of medications and chronic conditions for the risk of hospitalisation among an elderly population. Design This is a case-control study. Setting Population-based study in 2013 of all individuals aged 75 years and older (17 203) in the county of Blekinge in the southeast of Sweden. Participants
A search for dijet resonances in events with at least one isolated charged lepon is performed using 139 fb−1 of s = 13 TeV proton-proton collision data recorded by the ATLAS detector at the LHC. The dijet invariant-mass (mjj) distribution constructed from events with at least one isolated electron or muon is searched in the region 0.22 < mjj< 6.3 TeV for excesses above a smoothly falling backgroun
The Global Lung Function Initiative (GLI) has recently published international reference values for diffusing capacity of the lung for carbon monoxide (DLCO). Lower limit of normal (LLN), i.e. the 5th percentile, usually defines impaired DLCO We examined if the GLI LLN for DLCO differs from the LLN in a Swedish population of healthy, never-smoking individuals and how any such differences affect id
Background: Although used extensively worldwide, the effects of general anaesthesia on the human brain remain largely elusive. Moreover, general anaesthesia may contribute to serious conditions or adverse events such as postoperative cognitive dysfunction and delirium. To understand the basic mechanisms of general anaesthesia, this project aims to study and compare possible de novo neuroplastic ch
