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In order to identify the signal epitopes of the neuropeptide Y (NPY) molecule, the conformation of the NPY molecule was pertubated by a systematic double D-amino acid replacement of neighbouring residues. These NPY-analogs were examined for receptor affinity and on biological activity. The rat cerebral cortex and hippocampus were used for binding characteristics on Y1 and Y2 binding sites, respect
Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis
Abstract Noroviruses are now the leading cause of gastroenteritis worldwide. Noroviruses are effectively transmitted due to a low infectious dose, viral shedding in high concentrations, environmental stability, and they induce only a limited immunity after infection. Especially, the norovirus variants of genotype II.4 (GII.4) have seemed greatly adapted for pandemic spread. The high infectivity o
The incidence of narcolepsy type 1 (NT1) increased in Sweden following the 2009-2010 mass-vaccination with the influenza Pandemrix-vaccine. NT1 has been associated with Human leukocyte antigen (HLA) DQB1*06:02 but full high-resolution HLA-typing of all loci in vaccine-induced NT1 remains to be done. Therefore, here we performed HLA typing by sequencing HLA-DRB3, DRB4, DRB5, DRB1, DQA1, DQB1, DPA1
Background: Screening that includes digital breast tomosynthesis (DBT) with two-dimensional (2D) synthetic mammography (SM) or standard 2D digital mammography (DM) results in detection of more breast cancers than does screening with DM alone. A decrease in interval breast cancer rates is anticipated but is not reported. Purpose: To compare rates and characteristics of (a) interval breast cancer in
OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each
Background: The prognosis of Alzheimer’s disease (AD) might be influenced by many sociodemographic and clinical factors. Previous studies have investigated the main effects of critical predictors but few have analyzed potential interactions. We have studied the long-term cognitive outcome, nursing home placement (NHP) and mortality by interactions between factors in cholinesterase inhibitor (ChEI)
Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part I, a retrospective joint analysis of cases diagnosed during a 20-year period. Methods: Patients with follow-up and tumor samples, treated between 1990 and 2010, in 93 centers/9 countries. Samples w
utomotive systems offer a rich opportunity for hybrid models, controls, and tools. Beyond the traditional use of hybrid models for representing the behavior of the composition of discrete controller and continuous plants, automotive mechanical systems exhibit hybrid behavior as demonstrated in this chapter. In addition, hybrid systems can be used to capture system specifications at the highest lev
Ozone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead®). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3/kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filamOzone was applied to return activated sludge in full-scale to study how ozone impacts filamentous bacteria viability (Live/Dead®). Additionally, the ozonated sludges were subjected to anaerobic digestion trials and analysis of micropollutants. Ozone treatment (3-4.8 g O3/kg TSS) improved the settling properties of the sludge by lowering the diluted sludge volume with 7-35%. Ozone inactivated filam
The current research focuses in understanding how inlet pressure, EGR, combustion phasing, engine speed and pilot main ratio are affecting the main parameters of the combustion (e.g. efficiency, NOx, soot, maximum pressure rise rate) in the novel concept of injecting high octane number fuels in partially premixed combustion. The influence of the above mentioned parameters was studied by performing
Using alternative fuels like Natural Gas (NG) has shown good potentials on heavy duty engines. Heavy duty NG engines can be operated either lean or stoichiometric diluted with EGR. Extending Dilution limit has been identified as a beneficial strategy for increasing efficiency and decreasing emissions. However dilution limit is limited in these types of engines because of the lower burnings rate of
The behavior of Ethanol and seven fuels in the boiling point range of gasoline but with an Octane Number spanning from 69 to 99 was investigated in Partially Premixed Combustion. A load sweep was performed from 5 to 18 bar gross IMEP at 1300 rpm. The engine used in the experiments was a single cylinder Scania D12. To allow high load operations and achieve sufficient mixing, the compression ratio w
It is tractable to increase the torque for an HCCI engine and one way is to add a turbocharger. Operating in HCCI mode requires accurate control of the combustion phasing, CA50. The higher the engine torque, the narrower the CA50 window becomes where HCCI operation is maintained. As the CA50 varies stochastically between cycles this requires improved CA50 control for turbo HCCI engines. The main f
By using a turbo the operating range of the HCCI engine can be increased, but at the expense of increased controller complexity. The dynamics the turbo introduces in the intake and the exhaust manifolds, have a large impact on the in-cylinder mixture temperature, pressure and finally the combustion phasing. To compensate for this and to maintain desired combustion phasing, precise control of the n
For diesel engines the major exhaust problem is particulate matter and NOx emissions. To reduce NOx, exhaust gas recirculation (EGR) is often used. The behavior of the EGR-level will therefore influence the emissions and it is therefore valuable to keep track of the EGR-level. Especially during transients it is difficult to predict how the EGR-level varies. In this paper the CO2-level in the intak
Partially Premixed Combustion (PPC) is a combustion concept by which it is possible to get low smoke and NOx emissions simultaneously. PPC requires high EGR levels and injection timings sufficiently early or late to extend the ignition delay so that air and fuel mix extensively prior to combustion. This paper investigates the operating region of single injection diesel PPC in a multi cylinder heav
A diesel engine developed for an international market must be able to run on different fuels considering the diesel fuel qualities and the increasing selection of biofuels in the world. This leads to the question of how different fuels perform relative to a standard diesel fuel when not changing the hardware settings. In this study five fuels (Japanese diesel, MK3, EN590 with 10% RME, EN590 with 3
Natural gas and hydrogen enriched natural gas has been tested as fuels together with diesel oil and RME in a single cylinder Scania research engine. The gas was introduced as port injection while the diesel was introduced as early direct injection. Because the gas was premixed with air before combustion and the diesel was injected early in the compression stroke, the engine ran close to HCCI mode.
