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Introduction. Manual delineation of the left ventricle is clinical standard for quantification of cardiovascular magnetic resonance images despite being time consuming and observer dependent. Previous automatic methods generally do not account for one major contributor to stroke volume, the long-axis motion. Therefore, the aim of this study was to develop and validate an automatic algorithm for ti
In this study, a new supercritical fluid chromatography-mass spectrometry (SFC-MS) method has been developed for the separation of nine vitamin D metabolites within less than eight minutes. This is the first study of analysis of vitamin D and its metabolites carried out by SFC-MS. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene
Despite progress over the last decades, East Africa has one of the highest ratios of preventable maternal mortality in the world. This qualitative case study sheds light on Midwife-Led Care (MLC) in Ethiopia, Kenya, Malawi and Somalia. MLC is a model of care associated with improved health outcomes and enhanced utilization of health systems resources. Nevertheless, the model is not properly integr
Objectives: Multi-stakeholder partnership is garnering greater attention worldwide as a means of tackling global wicked problems, implementing sustainable development and leveraging development cooperation. By adopting meta-governance approach, this study investigates the case study of Hoi An - A Green Destination partnership in the waste management context of Hoi An city, Vietnam to understand ho
PurposeCombination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.Materials and methodsThis prospective study e
The thesis examines the truth and reconciliation commission in South Africa and its possibilities to act as a vehicle in the process of consolidating democracy. The norms and values that can be found in the principles and practices of the commission are scrutinized, and the means of presenting this norms to the public is also looked into. The issue of how to deal with the human rights violations o
This research approaches public administration reform in China from a domestic perspective. Whereas recognizing that the mechanisms behind the nature differ from the principle of New Public Management (NPM) of Anglo-Saxon tradition, the reform initiatives are similar. Municipal governments were encouraged to carry out NPM Reform towards governance model since 1998 to serve dual-purpose. That is st
Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin
Soil erosion poses a significant environmental challenge in Dehradun due to its complex, steep terrain, heavy rainfall, and rapid urbanization. This study employed a Google Earth Engine-based approach to assess the average soil loss annually using the Revised Universal Soil Loss Equation (RUSLE). The analysis used various factors, including rainfall-runoff erosivity (R), soil erodibility (K), slop
No abstract. Prepared for Linnédelegationen, Stockholm, Sweden.
Aim Climate change is having far-reaching effects on the global environment. Here, the ALARM (Assessing Large-scale Risks for Biodiversity with Tested Methods, European Union 6th Framework Programme) climate change scenarios were used to assess changes to the fate of selected persistent organic pollutants (POPs). Scenarios detailing climate and land-cover changes, such as precipitation, temperatur
A measurement is reported of the production cross section of top-quark pairs (t (t) over bar) in proton-proton collisions at a center-of-mass energy of 7 TeV recorded with the ATLAS detector at the LHC. Candidate events have a signature consistent with containing two isolated leptons, large missing transverse momentum, and at least two jets. Using a data sample corresponding to an integrated lumin
Objectives To evaluate in a prospective, randomized clinical trial (RCT), symptom response among obese knee osteoarthritis (OA) patients following a feasible. intensive weight-loss program for 16 weeks Methods Eligible patients were obese [body mass index (BMI)> 30 kg/m(2)], >50 years old, with primary knee OA Participants were randomized to either a very-low-energy diet (VLED) or a low-energy die
Prostate-specific antigen (PSA) testing has limited accuracy for the early detection of prostate cancer (PCa).
AZD0837 is a novel oral anticoagulant investigated in clinical studies for stroke prevention in patients with atrial fibrillation (AF). It is bioconverted to its active form, AR-H067637, a potent, specific and reversible thrombin inhibitor.
The use of nucleoside phosphorylases (NPs; EC 2.4.2.n) represents a convenient alternative to the chemical route for the synthesis of natural and modified nucleosides. We purified four recombinantly expressed nucleoside phosphorylases from the bacterial pathogens Citrobacter koseri, Clostridium perfringens, and Streptococcus pyogenes (CkPNPI, CkPNPII, CpUP, SpUP) and their substrate specificity wa
