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Obesity is a known risk factor for poor breast cancer outcomes, but its impact on endocrine therapy efficacy remains unclear. While the ATAC trial suggests reduced effectiveness of aromatase inhibitors (AIs) in women with obesity, the BIG 1–98 trial found no significant differences. Clinical and biological evidence indicates that obesity may impair AI efficacy by increasing aromatase activity and
OBJECTIVES: Telehealth, the provision of healthcare through digital communication, has been proposed as a potential solution to meet the increasing demand for healthcare, particularly in the setting of the COVID-19 pandemic. Sweden has an established national telehealth service for triage and referral by phone (1177) since 2013 which has the potential to meet this increasing demand. However, littl
The increasing importance of mode selection in supply chain management, driven by factors such as globalisation, environmental concerns and safety requirements, has led Power Electronics to re-evaluate its current reliance on road freight transportation within the United States. In response to the growing awareness of sustainability, Power Electronics intends to explore the viability of rail trans
This thesis explores arguments and styles of argumentation in favour of Scotland gaining independence and rejoining the European Union in the aftermath of the United Kingdom leaving the EU in 2020. Since a majority of Scots did not support Brexit, it has provided Scottish independence supporters with a unique opportunity to bolster their arguments in the political debate. The thesis is built on a
Over the past decade, the field of Inner Transformation for Sustainability has grown into a substantial and influential body of knowledge, providing much of the scientific foundation for the Inner Development Goals (IDGs). In this conversation, Professor Christine Wamsler and Tomas Björkman reflect on the current state of the field. They emphasize that any meaningful application of the IDG Guide r
In this thesis, issues surrounding climate actions are analysed through the notion of corporate due diligence in the European Union (EU) context. The study explores how mandatory climate change due diligence schemes, potentially in the form of a legally binding instrument, may affect the critical sector of energy-intensive industries (EIIs) in the Union and further contribute to the broader EU cli
Bilaga 2, INS PROTOKOLL INS 2024-09-04 DIARIENR STYR 2024/2043 2024-09-16 PROTOKOLL INSTITUTIONSSTYRELSEN VID TEATERHÖGSKOLAN I MALMÖS ORDINARIE MÖTE 2024-09-04 NÄRVARANDE Fredrik Haller Sven Bjerstedt Erik Pold Fredrika Tungström Jan Michelsen Richard Kolnby Christine Thoulouis FRÅNVARANDE Julia Gebauer Zsofia Kosma §1 Information från fakultetskansliet. Ingen närvarande representant från fakulte
https://www.thm.lu.se/sites/thm.lu.se/files/2024-10/Protokoll%20INS%202024-09-04,%20bilaga%202-signed.pdf - 2026-07-23
Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
The stability and activity of a model protein, lysozyme, in 1 : 2 choline chloride : glycerol was characterised across a wide range of protein concentrations, i.e., between 4 and 143 mg ml−1, where the protein is soluble and physically stable. Lysozyme folds into a globular conformation in this deep eutectic solvent like that in the native state, but with subtle variations in its internal structur
Proteomics is widely utilized to understand the function of cellular processes at the molecular level. Using liquid chromatography interfaced with mass spectrometry (LC-MS)-based proteomics, thousands of proteins can be identified and quantified in a single experiment and their relationship and interactions can be analyzed. This makes the analysis of high-throughput proteomics data a cornerstone i
Objective Ultrasound is a promising tool to foster much-needed improvement of skin assessment in systemic sclerosis (SSc). Our aim was to develop evidence and expert opinion-based recommendations to promote the standardisation and harmonisation of technical execution and reporting of skin ultrasound studies in SSc. Methods A multidisciplinary task force of 16 members from five European countries a
The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food con-sumption
This paper proposes a critical analysis of the innovative jurisprudential approaches taken by the Inter-American Court of Human Rights in integrating the content and scope of protection of the human rights of children, in the context of migration processes. How might one provide an effective protection to unaccompanied children that enter irregularly into the territory of a given country, when the
Background: Randomised clinical trials with a factorial design may assess the effects of multiple interventions in the same population. Factorial trials are carried out under the assumption that the trial interventions have no interactions on outcomes. Here, we present a protocol for a simulation study investigating the consequences of different levels of interactions between the trial interventio
Studies on patients with bladder outflow obstruction who have undergone surgery for benign prostatic hyperplasia, successfully relieving the obstruction, have revealed a persistence of storage symptoms associated with detrusor overactivity (DO) in 20% to 40% of patients. To study the underlying mechanisms, we have used a common rat model of obstruction/de-obstruction, assuming that non-voiding con
Severe obesity during childhood is associated with cognitive deficits. Studies in adults have suggested improvements in executive functioning and memory after bariatric surgery. Our aim was to explore changes in cognitive function in adolescents over two years after bariatric surgery or intensive non-surgical treatment. Methods: The Adolescent Morbid Obesity Surgery 2 (AMOS2) is a multicentre, ope
Background: Etranacogene dezaparvovec, the first gene therapy approved for haemophilia B treatment, was shown to be superior to treatment with continuous prophylactic factor IX in terms of bleeding protection 18 months after gene therapy in a phase 3 trial. We report post-hoc 24-month efficacy and safety data from this trial to evaluate the longer-term effects of etranacogene dezaparvovec in indiv
Radioactive iodine is commonly used for the treatment of different thyroid conditions since the 1940s. The EANM has developed a standard pre-therapeutic procedure to estimate patient specific thyroid uptake at treatment of benign thyroid diseases. The procedure which models the time dependent fractional thyroid uptake is based on a two-compartment fitting system, one representing the thyroid and t
