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BackgroundLong-term oxygen therapy (LTOT) given for at least 15 hours/day improves survival in patients with severe chronic hypoxemia. However, the recent REDOX trial showed that LTOT prescribed for 24 hours/day was not superior to 15 hours/day in terms of death, hospitalizations, or self-reported outcomes. We aimed to examine the cost effectiveness of prescribing LTOT for 24 versus 15 hours/day.M

Bakgrund: God kommunikativ och empatisk förmåga hos läkare skapar trygghet och upplevs som professionellt av patienter och närstående. Forskning visar att empati förbättrar patienters följsamhet, nöjdhet och relationen mellan läkare och patient, vilket i sin tur leder till högre vårdkvalitet, bättre behandlingsresultat och minskade vårdkostnader. Ett empatiskt förhållningssätt främjar både fysisk

Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bior

The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,

Integrated models are inherently complex and often obscure to any but those who write them. Their usefulness can be greatly enhanced through well-structured, object-oriented design. A robust and computationally efficient Simulink/C++ library of optics, control, finite-element, and visualization routines for modeling radio telescope performance under various operating conditions is being developed

The Euro50 is a proposed optical telescope with an equivalent aperture of 50 m. It will have a segmented primary mirror and full adaptive optics. To study the interaction of the telescope structure, the control system and the optics, an integrated simulation model has been formulated. The mechanical model is a modal version of an Ansys finite element model. The optics model is based on ray tracing

The underpinning idea of extended producer responsibility rules has been to provide incentives for manufacturers to design products that are easy to recycle. However, current incentives for design for recycling are limited, due to the problems in assigning costs for collection and recycling of individual products to the relevant producers. An alternative way to promote design for recycling, or to

Infrared laser-induced grating spectroscopy (IR-LIGS) is a powerful method for the detection of molecules in atmospheric and combustion chemistry by exploiting their strong and species-specific fundamental vibrations. This work discusses potentials and limitations of the method.

The Inter-American Court of Human Rights (IACrtHR) has developed in recent years an innovative jurisprudence that has integrated the entity and extension of States’ obligations regarding children’s rights—as established in Article 19 ACHR—through the evolutive, dynamic, and effective interpretation of the American Convention on Human Rights (ACHR). In fact, by acknowledging the existence of an int

OBJECTIVE:Recent advances in AI-based Large Language Models (LLM) can transform individuals’ descriptions of emotional health into numeric representations that predict rating scales with an accuracy approaching theoretical upper limits. This advancement enables examing various open-ended response formats. We develop and evaluate formats ranging from closed to more open: 1) selecting descriptive wo

This paper showcases new research avenues made possible by applying computational methods to historical isiXhosa text. I outline a method for isiXhosa computational text analysis which adapts word frequency analysis to be applied to isiXhosa texts focusing on root words. The paper showcases the value of the approach in a study of emerging political identities in early African nationalism, examinin

Legal persons have traditionally been understood as entities with legal rights and/or duties. This traditional concept of legal personhood has been challenged during the last decades: In legal practice through the global development in law where previous legal non-persons such as different non-human natural entities, non-human animals, fetuses and artificial intelligences have been ascribed, or be

Some leading science programs undertaken with Very Large Telescopes and challenges driving the progress of the Extremely Large Telescopes are discussed together with the corresponding requirements. They concern expolanets, Earth-like planets, habitable zones, formation of stars and galaxies, first stars and cosmology. A description is attempted