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Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC l
Background. School health programs need to target all aspects of physical, psychological, and social well-being. Using a slightly modified version of the COSMIN Risk of Bias checklist, we developed and conducted the first validation of the School Health Assessment Tool for Primary Schools (SHAT-PS). Method. The exploratory sequential mixed method was used in this study. In the first phase, scienti
The purpose of this perspective article is to critically explore the launch of the mission for 100 climate neutral cities in Europe. An overview of the mission approach in general is first presented, where key aspects and emerging critiques are identified. Second, key elements of the mission for 100 climate neutral cities in Europe are introduced along with some of its challenges and ambiguities.
Accuracy in MP2RAGE-based T1-mapping relies on knowledge of the imperfect inversion efficiency (finv) of the inversion pulse. Here we map the inversion efficiency of different adiabatic inversion pulses in human brain at 7T. We identified a mean finv=0.86, which is substantially lower than the finv=0.96 typically assumed in MP2RAGE. We further observed a lower finv in white matter (WM) than in the
The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh
In recent years there has been a great deal of discussion on the potential for a shift away from modernistic or technocratic approaches to decisionmaking on risk towards more open, inclusive, and deliberative approaches. The authors consider (a) the reasons why some companies have taken the first step in this transition by exploring the potential of more open and communicative approaches to enviro
Fast-moving consumer goods (FMCGs) are products that have a short useful lifetime and are typically designed for single or limited uses followed by disposal. The disposable nature of FMCGs combined with ineffective waste recovery systems is causing global environmental problems. Various reusable packaging business models have emerged to tackle these problems; however, their influence is still low
We give a complete proof of the classical Benjamin and Lighthill conjecture for arbitrary two-dimensional steady water waves with vorticity. We show that the flow force constant of an arbitrary smooth solution is bounded by the flow force constants for the corresponding conjugate laminar flows. We prove these inequalities without any assumptions on the geometry of the surface profile and put no re
Background: Chronic lung disease (CLD) occurs frequently in preterm infants and is associated with respiratory morbidity. Bronchodilators have the potential effect of dilating small airways with muscle hypertrophy. Increased compliance and tidal volume, and decreased airway resistance, have been documented with the use of bronchodilators in infants with CLD. Therefore, bronchodilators are widely c
Heart failure (HF) is a leading cause of death and disability globally. HF represents the common end- stage of most heart conditions, during which the heart is unable to generate sufficient output of blood for the metabolic demands of the body and intracardiac pressures increase. Different heart diseases display specific molecular pathophysiologies, but common pathways are also present that drive
During the last decade, the application of strontium isotope analysis (87Sr/86Sr) has increased rapidly. The understanding of the strontium isoscape and the construction of a strontium isotope baseline in southern Scandinavia are biased toward Denmark and southwestern to eastern Scania. We report the results of new baseline samples in Halland and the Bjäre Peninsula, adding to the rich strontium i
A search for the associated production of a heavy resonance with a top-quark or a top-antitop-quark pair, and decaying into a tt¯ pair is presented. The search uses the data recorded by the ATLAS detector in pp collisions at s=13 TeV at the Large Hadron Collider during the years 2015–2018, corresponding to an integrated luminosity of 139 fb-1. Events containing exactly one electron or muon are sel
The nature of work has already, for some time, been undergoing major changes as a result of technological progress. Mobile, virtual and cloud technologies, and the infrastructures that support them, are increasingly enabling work to be done from anywhere and at any time. The COVID-19 pandemic has further accelerated this process, driving a large share of white-collar knowledge work to remote and h
Evacuation models commonly employ pseudorandom sampling from distributions to represent the variability of human behaviour in the evacuation process, otherwise referred to as ‘behavioural uncertainty’. This paper presents a method based on functional analysis and inferential statistics to study the convergence of probabilistic evacuation model results to inform deciding how many repeat simulation
We study the homogenization of the Dirichlet problem for the Stokes equations in R3 perforated by m spherical particles. We assume the positions and velocities of the particles to be identically and independently distributed random variables. In the critical regime, when the radii of the particles are of order m-1, the homogenization limit u is given as the solution to the Brinkman equations. We p
The trigeminal system is key to the pathophysiology of migraine and cluster headache, two primary headache disorders that share many features. Recently, MER proto-oncogene tyrosine kinase (MERTK), a cell surface receptor, was strongly associated with cluster headache through genetic studies. Further, the MERTK ligand galectin-3 has been found to be elevated in serum of migraine patients. In this s
