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The bone marrow (BM) niche is a complex cellular, molecular, and physical microenvironment capable of homing and supporting hematopoiesis. It is characterized by its ability both maintain and to drive hematopoietic stem and progenitor cells (HSPCs) self-renewal and differentiation which ultimately generate all blood cell types. However, how the niche elements interact in a human context remains la
As a research domain, the smart city keeps growing, despite the remaining contradictions and ambiguity related to its conceptual aspects. We propose to dig deeper into the complex socio-technical nature of the smart city and examine the concept through the lens of different public governance paradigms, therefore aligning it with the sustainability outcomes. Embracing interrelated dimensions of hum
We present a method that allows enabling matrix element corrections (MECs) in Pythia8 with MC@NLO matching, without incurring double counting. MECs are an interesting feature that may contribute to the accuracy of theoretical predictions, alongside matching and merging. We directly compare our method to a specific choice of settings in Pythia8, which can remove double-counting for MECs in certain
Tetrodotoxin (TTX) is a marine toxin responsible for many intoxications around the world. Its presence in some pufferfish species and, as recently reported, in shellfish, poses a serious health concern. Although TTX is not routinely monitored, there is a need for fast, sensitive, reliable, and simple methods for its detection and quantification. In this work, we describe the use of an automated pa
Objective: Emerging research suggests that rheumatoid arthritis (RA) is associated with intestinal dysbiosis. This prospective pilot study evaluates changes in intestinal microbial composition in patients with RA initiating treatment with either methotrexate (MTX) or a tumor necrosis factor inhibitor (TNFi). Methods: Consecutive patients, fulfilling the 2010 American College of Rheumatology/EULAR
Ethylene is one of the most important products in the emissions-intensive petrochemical industry. Decarbonizing the ethylene industry is thus important for achieving global carbon neutrality. This study is the first to explore future long-term zero-emissions production pathways for the ethylene industry in China, the world's biggest ethylene producer. An optimization model was built in the context
In this Perspective, we discuss thermal imbalance and the associated electron-mediated thermal transport in quantum electronic devices at very low temperatures. We first present the theoretical approaches describing heat transport in nanoscale conductors at low temperatures, in which quantum confinement and interactions play an important role. We then discuss the experimental techniques for genera
In this paper, a factor-augmented version of the New Keynesian Phillips curve (NKPC) is assessed using a data set comprised of a large panel of European Union (EU) member countries. The factor-augmentation is natural given that country-level inflation rates are highly co-moving. The presence of unattended common factors is important because it raises the issue of omitted variables bias, as the rea
The introduction of autonomous machines (AMs) in human domains has raised challenging questions about the attribution of responsibility; referred to as the responsibility gap. In this paper, we address the gap by arguing that entities should not be granted the freedom of action unless they can also recognise the same right for others—and be subject to blame or punishment in cases of undermining th
Microbial, algal, plant and animal cells have been immobilized, with preserved viability, by entrapment in various matrices according to a new bead polymerization technique. The cell polymer/monomer mixture is kept suspended in a hydrophobic phase such as soy, paraffin, or silicon oil, tri-n-butylphosphate, or dibutyphtalate, which is compatible with the cells. The various monomers or polymers tes
Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP)
This chapter seeks to explore the intersections between occupational cultures, bystanders, and social justice and inclusion based on the empirical example of policing. Specifically, we pursue the question: what is the role of police officers as bystanders to occupational police culture and how does that influence inclusion? Against the backdrop of occupational culture, we put forth four key aspect
In this paper, we recall Lepowsky's and Wakimoto's product character formulas formulated in a new way by using arrays of specialized weighted crystals of negative roots for affine Lie algebras of type Cl(1), Dl+1(2) and A2l(2). Lepowsky–Wakimoto's infinite periodic products appear as one side of (conjectured) Rogers–Ramanujan-type combinatorial identities for affine Lie algebras of type Cl(1).
The European Union (EU) and the EU member states have adopted a number of policies that can support circular economy developments in the electrical and electronic equipment (EEE) sector, and additional policies have been proposed. The policies include the new Ecodesign Regulation and a new Battery Regulation, and forthcoming rules related to durability and repairability of mobile phones and tablet
This paper introduces a new lifting method for analyzing convergence of continuous-time distributed synchronization/consensus systems on the unit sphere. Points on the d-dimensional unit sphere are lifted to the (d+1)-dimensional Euclidean space. The consensus protocol on the unit sphere is the classical one, where agents move toward weighted averages of their neighbors in their respective tangent
The physiological mechanism for producing antigen-specific antibodies is based on a two-phase neo-Darwinian process: the first phase consists of diversity generation (formation of the repertoire), and the second phase is antigen-mediated selection. In this article, we consider how the natural immunoglobulin gene-diversification processes can be exploited both in vivo and in vitro in order to allow
Microbial contaminants are responsible for several infectious diseases, and they have been introduced as important potential food- and water-borne risk factors. They become a global burden due to their health and safety threats. In addition, their tendency to undergo mutations that result in antimicrobial resistance makes them difficult to treat. In this respect, rapid and reliable detection of mi
This chapter brings the Global South to the centre stage of degrowth debates to envision what a truly global and anti-colonial movement towards degrowth could look like. To do so, we first bring the varying definitions of the term ‘Global South’ to the forefront and consider the Global South not as an undynamic and apolitical cate- gory, but as a site of resistance and independent critical thinkin
The discussion on the Anthropocene has increased the urgency to promote a sustainable society, considering the planetary boundaries, population growth and resource scarcity. Thus, the United Nations created the 2030 Agenda for Sustainable Development to address this challenge, including 17 Sustainable Development Goals (SDGs) and 169 SDG targets. In this context, the energy sector is one of the ma
The flavour-tagging algorithms developed by the ATLAS Collaboration and used to analyse its dataset of s=13 TeV pp collisions from Run 2 of the Large Hadron Collider are presented. These new tagging algorithms are based on recurrent and deep neural networks, and their performance is evaluated in simulated collision events. These developments yield considerable improvements over previous jet-flavou
