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By measuring X-ray emission of the water molecule in liquid phase we establish a first example of K-shell X-ray emission spectra with strong breakdown of the molecular orbital picture. A complete splitting of the 2a1 peak into satellites is observed. A theoretical model with electronic configurations generated by coupled excitations/de-excitations, so-called semi-internal configuration interaction
A 1D imaging soft X-ray spectrometer installed on the small quantum systems (SQS) scientific instrument of the European XFEL is described. It uses movable cylindrical constant-line-spacing gratings in the Rowland configuration for energy dispersion in the vertical plane, and Wolter optics for simultaneous 1D imaging of the source in the horizontal plane. The soft X-ray fluorescence spectro-imaging
The world is suffering from increasing weather extremes caused by climate change of which the building sector is a major contributor. There is however a large reduction potential in the sector and circular economy has received increased attention both within research and practice. This study explores circular futures within the building sector through the futures studies method of backcasting. Two
This article provides a new argument and a new value-theoretical ground for person-centered care and shared decision making that ascribes to it the role of enabling rational choice in situations involving clinical choice. Rather than referring to good health outcomes and/or ethical grounds such as patient autonomy, it argues that a plausible justification and ground for person-centered care and sh
Blood biomarkers have emerged as accessible, cost-effective, and highly promising tools for advancing the diagnostics of Alzheimer's disease. However, transitioning from cerebrospinal fluid biomarkers to blood biomarkers—eg, to verify amyloid β pathology—requires careful consideration. This Series paper highlights the main challenges in the implementation of blood biomarkers for Alzheimer's diseas
Background & objectives: Endoscopy is the current gold standard for evaluation of disease activity in ulcerative colitis. The Mayo Endoscopic Subscore (MES) is commonly used for quantifying disease activity, but it has several weaknesses. Numerous new endoscopic indices have been developed but none of these have been widely implemented, likely due to limited feasibility. The primary objective
To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI an
This theoretical paper adopts a procedural perspective to identify the challenges associated with the implementation of the full scope of approaches to circular public procurement (CPP). We contend that beyond considering CPP from a substantive standpoint (i.e. the procurement affects outside of the organization), adopting a procedural perspective (i.e. the procurement affects inside an organizati
Introduction: Rimegepant is an oral small-molecule calcitonin gene-related peptide receptor antagonist approved in several countries for acute treatment of migraine and preventive treatment of episodic migraine in adults. This review summarizes the evidence, published to date, for the use of rimegepant as an acute or preventive treatment of migraine. Areas covered: A brief overview of migraine, th
Recently, the incentive structure facing doctoral students and researchers in economics has changed significantly in many European countries as a result of the adoption of the US approach to evaluating research output. This poses a threat to the development and position of the subject of economics in Europe since evaluation for promotion is characterised by an excessive focus on publishing in the
Portal hypertension, a life-threatening complication of cirrhosis,is largely triggered by increased intrahepatic vascular resistance.Fibrosis, regenerative nodule formation, intrahepatic angiogenisis and sinusoidalremodelling are classical mechanisms that account for increasedintrahepatic vascular resistance in cirrhosis. Our study leverages highresolution3D synchrotron radiation-based microtomogr
Considering the Islamic perspective on forced migration and displacement, along with the conceptual framework of Islamic social welfare instruments as tools for wealth redistribution to support those in need, this study explores the potential complementarity between Islamic and conventional financing in addressing refugees' basic needs and economic empowerment. Specifically, this research examines
The search for drugs that modulate NMDA receptors has been very active in the latest decades since they play a pivotal role in neuronal death and in several neurological conditions, including stroke, traumatic brain injury, and neurodegenerative diseases. Activating the receptor evokes an entry of calcium into the neuron, thus leading to a rapid depolarization that can be measured using electrophy
BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC
Marine environments worldwide are increasingly threatened by warming, deoxygenation, and ocean acidification. These stressors can be recorded as alterations in foraminiferal geochemistry and morphology. We integrated morphological features with assemblage and geochemical records of benthic foraminifera from the Danish Straits at the entrance to the Baltic Sea, covering the Last Interglacial period
Background: The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes. Methods: Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrat
In clinical trials, surrogate endpoints, that are more cost-effective, occur earlier, or are more frequently measured, are sometimes used to replace costly, late, or rare true endpoints. Regulatory authorities typically require thorough evaluation and validation to accept these surrogate endpoints as reliable substitutes. To this end, the meta-analytic framework is considered a very viable approac
