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Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

Kursen behandlar breda programmeringsaspekter som är väsentliga för naturvetare. Det börjar med en grundläggande introduktion till relevant informationsteknik och avslutas med en fördjupad studie av ramverk för vetenskaplig dataanalys. Följande ämnen tas upp: Användning av ett UNIX-baserat operativsystem, till exempel Linux Översikt över användning av programmering i olika naturvetenskapligThe course covers broad programming aspects essential for scientists.  The following aspects are addressed: Use of UNIX-based operating systems, such as Linux Overview of the use of programming in various scientific fields (Data analysis, simulation, etc.​) Overview of common programming languages such as C++ and Python Basic concepts of object-oriented software design Basic Soft

Denna kurs introducerar lingvistikstudenten i forskningsmetodik och metodologiska frågor, och förbereder för uppsatsarbete på fördjupningsnivå. Kursen behandlar metodologiska frågor såsom att formulera frågeställningar, skillnaden mellan kvantitativa och kvalitativa metoder, induktiva och deduktiva metoder, och forskningsetiska frågor. Under kursen får du praktisk träning i några vanliga lingvistiThis course introduces the linguistic student to research methods and methodological issues, and prepares the student for writing an essay on B.A. level. The course includes methodological issues such as formulating research questions, the difference between quantitative and qualitative methods, inductive and deductive methods, and ethical questions. During the course, you will practice some commo

Målet med kursen är att träna studenten i att planera, avgränsa, genomföra, rapportera och kritiskt granska ett självständigt, skrivet examensarbete.The aim of the module is to train the students to plan, delimit, execute, report and critically review an independent, written dissertation.

A Master’s thesis is a scientific research project of limited scale that is intended to exhibit the student’s capacity to work independently and carry out research. The intension of the thesis is to make a genuine contribution of new knowledge, written in the genre of scientific research. The course involves students independently designing and completing a research project within the discipline oA Master’s thesis is a scientific research project of limited scale that is intended to exhibit the student’s capacity to work independently and carry out research. The intension of the thesis is to make a genuine contribution of new knowledge, written in the genre of scientific research. The course involves students independently designing and completing a research project within the discipline o

Information på svenska längre ner på sidan Course name: SOCM05, Sociology: Master's (Two years) Thesis. (Swedish name: Sociologi: Examensarbete för masterexamen). Advanced level/Master Course (Second Cycle). 30 credits. Autumn and spring semester.  This course can be studied as a freestanding course or can be included in a Master of Science (120 credits) degree specialising in sociology. To b