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Design, evaluation, and in vitro–in vivo correlation of self-nanoemulsifying drug delivery systems to improve the oral absorption of exenatide

The ability to predict the absorption of exenatide (Ex), a GLP-1 analogue, after oral dosing to rats in self-nanoemulsifying drug delivery systems (SNEDDS), using in vitro methods, was assessed. Ex was complexed with soybean phosphatidylcholine (SPC) prior to loading into SNEDDS. A design of experiments (DoE) approach was employed to develop SNEDDS incorporating medium-chain triglycerides (MCT), m

Temporal Patterns of Glucagon and Its Relationships with Glucose and Insulin following Ingestion of Different Classes of Macronutrients

Background: glucagon secretion and inhibition should be mainly determined by glucose and insulin levels, but the relative relevance of each factor is not clarified, especially following ingestion of different macronutrients. We aimed to investigate the associations between plasma glucagon, glucose, and insulin after ingestion of single macronutrients or mixed-meal. Methods: thirty-six participants

Controlling Destiny : Julian Huxley's Post-Darwinian Evolutionism and the History of Transhumanism

The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. It was Huxley’s firm belief that mankind needed a unifying system of thought that could motivate action and change. Transhumanism was also an attempt to unite a more traditional humanistic view of the human as containing some form of core essence The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. It was Huxley’s firm belief that mankind needed a unifying system of thought that could motivate action and change. Transhumanism was also an attempt to unite a more traditional humanistic view of the human as containing some form of core essence

Complication rate after gastrostomy placement in children can be reduced by simple surgical steps

AIM: To evaluate if the incidence of postoperative complications after gastrostomy placement is correlated to perioperative parameters or patient characteristics.METHODS: In this prospective observational study, children <18 years of age planned to receive a gastrostomy at partaking clinics between 2014 and 2019 were invited. Pre-, peri- and postoperative variables were collected and followed up 3

Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival

The prognostic impact of t(12;21)(p13;q22) [ETV6/RUNX1 fusion] in paediatric acute lymphoblastic leukaemia (ALL) has been extensively debated, particularly with regard to the frequency of late relapses and appropriate treatment regimens. We have retrospectively collected 679 ALLs with known ETV6/RUNX1 status, as ascertained by fluorescence in situ hybridization or reverse-transcription polymerase

Nymu utbildningsplaner samlingsdokument piano mas

36 1. IDENTIFIKATION Programmets namn och inriktning: musikerutbildning, piano. Omfattning i högskolepoäng: 120. Nivå: Avancerad nivå (A). Programkod: KAMUS: Inriktning: PIAN. 2. BESLUTSUPPGIFTER Utbildningsplanen är reviderad och beslutad av konstnärliga fakul- tetsstyrelsen den 18 oktober 2017. Den reviderade utbildningspla- nen träder i kraft HT-17. 3. PROGRAMBESKRIVNING Musikerutbildning, pian

https://www.mhm.lu.se/sites/mhm.lu.se/files/nymu_utbildningsplaner_samlingsdokument_piano_mas.pdf - 2026-05-23

Wings 2013 fritsches

Leadership slides.pptx !"#$%&"'()*+,-%( !./0)(1-2,-#%&+'(!"#$%&"'(34(567(389:( ;"'<#+7&=(>"%=,"?@#2+A+A7( BBBC'"%=,"?=#2+A+A7C?"D( ( ( !"#$"%&'()*+,%-&',)* !./0)! ! E#(F-#%GA(H#+=%?&-%( >"%=,"?@#2+A+A7( !"#$%&"'(5+D%( 1-2,+A7(I(*+J-*"A7(*-2#A+A7( •! @""*%(2A,(D+A,%-=( ( K-A-L=%("A(3(*-M-*%N( 9C! O"6#("BA(*-2,-#%&+'(%$+**%(2A,(?&2**-A7-%( 3C! 5?GM+G-%(="(,"(B+=&(<"6#("BA(7#"6'(( ( ( ( !&"(2D(.P( •!

https://www.wings.lu.se/sites/www.wings.lu.se/files/wings_2013_fritsches.pdf - 2026-05-23

Factors affecting knee abduction during weight-bearing activities in individuals with anterior cruciate ligament reconstruction

Objective: To investigate if muscle strength and muscle activation patterns are associated with increased knee abduction during two functional tasks, commonly used in rehabilitation for individuals with anterior cruciate ligament reconstruction (ACLR). Design: Cross-sectional study. Setting: Laboratory. Participants: 24 women and 29 men approximately 7 months after ACLR. Main outcome measures: Iso

Oxidative DNA damage in human sperm influences time to pregnancy

BACKGROUND: Oxidative stress and related DNA damage in human sperm may be important for fecundity and pregnancy outcome. METHODS: We studied the level of oxidative DNA damage in terms of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) in sperm DNA among 225 first-pregnancy planners. Over the six menstrual cycle follow-up time, after cessation of contraception, 135 pregnancies were conceived. RESULTS: Th

Mobility and mobility-related participation outcomes of powered wheelchair and scooter interventions after 4-months and 1-year use.

Purpose: The aim was to investigate outcomes of powered wheelchair and scooter interventions after 4-months and 1-year use regarding need for assistance when moving around, frequency of mobility-related participation, easiness/difficulty in mobility during participation, and number of participation aspects performed in everyday life. Method: The study was a prospective cohort study, using an instr

Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers

The role of nitric oxide (NO) in migraine has been studied in the experimental glyceryl trinitrate (GTN)-infusion headache model. We hypothesized that GTN-induced headache may activate the trigeminovascular system and be associated with increased levels of sensory neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and so

Natural history of patients with unoperated atherosclerotic carotid artery disease--results from a retrospective study

The natural history of carotid artery disease was studied in a retrospective study of 609 angiograms performed during 1969-1979 on patients who had subsequently not been operated on. The indication for angiography differed, but was aimed at clarifying suspected cerebrovascular events. 578 patients could be followed-up after a median time of 10.4 years (0-22). The median survival time after angiogr

SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening

We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contrala

Outcome of poor response paediatric AML using early SCT

Background Children with poor response acute myeloid leukaemia (AML) generally have a very poor outcome. Allogeneic stem cell transplantation (SCT) is often recommended for these children but the benefit is unclear. The aim of this study was to investigate survival for poor response AML patients treated with SCT. Material and Methods Treatment was given according to the NOPHO-AML 2004 protocol. Al

Wheat bran increases high-density-lipoprotein cholesterol in the rat

1. Five groups of male Sprague Dawley rats were given for 6 months a diet with high protein and fat contents but a very low dietary fibre content (group B), and this diet mixed with (g/kg) 50 low-methoxyl pectin (group L), 50 high-methoxyl pectin (group H), 50 guar gum (group G) and 200 wheat bran (group WB, corresponding to 100 wheat fibre) respectively. 2. The weight increment was significantly

Final simm49 191218

FINAL SIMM49 191218.pdf SIMM49 GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Experimental Design for Social Scientists 
 Version 1.0, March 2020 For an always up-to-date online version, please visit the course site (check regularly for updates) Welcome! SIMM49 Welcome to the Spring term’s course Experimental Design for Social Scientists The aim of the course is to introduce the stud

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/final_simm49_191218.pdf - 2026-05-23

Øresundsnätverket April 2023

Øresundsnätverket för kønshistorisk forskning Forårskonference på Arbejdermuseet i København 2023 Hvornår? Fredag 28. apil 2023 kl. 13.15-18.00 Hvor? Arbejdermuseet, Rømersgade 22, 1362 København K, mødelokale Pio Program 13.15-13.30: Velkommen 13.30-14.30: Ulrika Holgersson (keynote, LU): Arbetarkvinnor - en forskningsresa. 14.30-14.45: Kort pause 14.45-15.15: Nina Trige Andersen: 'Hendes Virksom

https://www.cors.lu.se/sites/cors.lu.se/files/2025-01/%C3%98resundsna%CC%88tverket%20april%202023.pdf - 2026-05-23

Hypothalamic neurogenesis in intact brain and following injury

Neurogenesis in the adult mammalian brain is well studied, in the two main regions subventricular zone (SVZ) and subgranular zone (SGZ), under different physiological and pathological condition. Recent studies also revealed newly formed neurons in other parts of the brain including the hypothalamus. However, how robust neurogensis in this area is, is still unclear. In this study we used a novel re

Local treatment of cancellous bone grafts with BMP-7 and zoledronate increases both the bone formation rate and bone density.

Background and purpose The remodeling of morselized bone grafts in revision surgery can be enhanced by an anabolic substance such as a bone morphogenetic protein (BMP). On the other hand, BMPs boost catabolism and might cause a premature resorption, both of the graft and of the new-formed bone. Bisphosphonates inactivate osteoclasts and can be used to control the resorption. We studied a combinati