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Infections in cystic fibrosis (CF), often involving Pseudomonas aeruginosa, result from a dysregulated airway immunity where one hallmark is the accumulation of necrotic and apoptotic immune cells, in particular neutrophils. In addition, neutrophils actively release DNA, forming neutrophil extracellular traps (NETs) that contain antimicrobial proteins. Altogether, free DNA in complex with actin ac
Through enhancement of 6-mercaptopurine (6MP) bioavailability and inhibition of purine de novo synthesis, high-dose methotrexate (HD-MTX) may increase incorporation into DNA of 6-thioguanine nucleotides, the cytotoxic metabolites of 6MP. Patients with intermediate activity of thiopurine methyltransferase (TPMTIA) have higher cytosol 6-thioguanine nucleotide levels. We investigated toxicity followi
Background: With this study, we aim to explore pre-operative probabilistic expectations (what does the patient realistically expect) and value-based expectations (what does a patient consider important), post-operative expectation fulfillment, and the relationship with post-operative satisfaction in shoulder arthroplasty (SA) patients. We hypothesized that higher expectation fulfillment is related
Background. Neutrophils from patients with chronic kidney disease (CKD) are dysfunctional and thus a contributing factor to the risk of infections. The mechanisms for leucocyte dysfunction in CKD are not fully understood. It is known that lipopolysaccharide (LPS) activates transcription of several genes encoding proinflammatory cytokines. We therefore aimed to study the effect of LPS on neutrophil
Objective: An elevated sodium-to-potassium (Na/K) ratio in urine increases the risk of hypertension. Tooth loss in older adults can lead to a diminished nutritional state, including alterations in the Na/K ratio. However, the relationship between denture use and changes in the Na/K ratio among individuals with tooth loss has not been sufficiently explored. This study examined whether denture use m
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel
https://www.mhm.lu.se/internt/staff - 2026-07-03
Those who carry the mutated gene will develop the fatal Huntington’s disease at some stage in life. The brain disease, which can be inherited across generations, begins slowly and makes it increasingly difficult for sufferes to regulate their feelings, thoughts, and eventually movements. There is still no treatment. However, Huntington researcher and psychiatrist Åsa Petersén is working hard at it
Popular Abstract in Swedish Grupp B streptokocker (GBS; Streptococcus agalactiae) är den vanligaste orsaken till livs-hotande infektioner hos nyfödda barn. Enbart i USA orsakar GBS ~10 000 fall av meningit (hjärnhinneinflammation), pneumoni (lunginflammation) och sepsis (blodförgiftning) varje år. Infektionerna har hög dödlighet och en stor del av de barn som överlever infektionerna får bestående Streptococcus pyogenes (group A streptococcus) and the group B streptococcus (GBS) are two important human pathogens that cause different types of diseases and express different surface structures implicated in virulence. This thesis focuses on several surface proteins expressed by these pathogens, analyzing the biological function of these proteins and their ability to elicit protective immunity.
This PhD thesis deals with anthropomorphic images from the Vendel and Viking Ages, their contexts and functions. The images are seen as means of communication with “effective power” or agency ("Wirkmächtigkeit"). They could have had a relationship of interaction or partial identity with what was represented, due to the fact that the Vendel and Viking Age societies were largely based on oral tradit
The main purpose of this study is to examine whether a specific group of non ideal crime victims senses that the standard view of the ideal crime victim stands in the way of them getting the help from the judiciary that they are entitled to. If a discrepancy between theory and practice do exists, then why does it exist and what changes need to be done to eliminate it? These questions have been s
Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under
The mass mobilization and the collective political engagement of the Gezi Park protests of 2013 came as a surprise for many in Turkey. What was new about these large-scale demonstrations was not only the sheer number of people taking place in them (more than 3.5 million), but rather the expansive range of the protesters.This presentation looks into the Gezi events through a research question of Ho
Genom Sveriges implementering av EU:s 2014 års upphandlingsdirektiv innehåller svensk rätt sedan år 2017 såväl fakultativa som obligatoriska bestämmelser om ställandet av arbetsrättsliga villkor i offentliga upphandlingar. Denna uppsats identifierar dock flera praktiska svårigheter gällande användandet av dessa bestämmelser på grund av den svenska arbetsmarknadsmodellens särdrag. I brist på en lagThrough Sweden's implementation of EU’s 2014 public procurement directives the Swedish legal system contains since 2017 optional and mandatory statutes regarding specific labour law requirements in public procurement. This thesis however identifies several practical difficulties regarding the use of these statutes because of the characteristics typical for the Swedish labour market model. The
Det straffrättsliga orsaksbegreppet har främst diskuterats i rättsvetenskaplig doktrin, eftersom det saknas en legaldefinition och mängden rättspraxis kring begreppet är begränsad i Sverige. År 2024 kom dock ett avgörande, NJA 2024 s. 36, där Högsta domstolen för första gången uttryckligen diskuterade orsaksbegreppet. Rättsfallet handlade om alternativ kausalitet i form av alternativa dödsorsakThe concept of causation in criminal law has been discussed mainly in legal doctrine, since there is no legal definition, and the amount of case law regard ing the concept is limited, in Sweden. In 2024, a decision was made, NJA 2024 s. 36, where the Swedish Supreme Court explicitly discussed the con cept of causation for the first time. The case was about alternative causality in the terms of
Den 9 december 1948 antogs konventionen om förebyggande och bestraffning av brottet folkmord. Begreppet “folkmord”, myntat av den framlidne professorn Raphael Lemkin, definieras som den systematiska förintelsen av gruppers grundläggande livsvillkor med syftet att förinta gruppen i sig. I artikel II av folkmordskonventionen definieras folkmord istället som handlingar som “förövas i avsikt att förin
The detailed interactions of nitrogen oxides with ice are of fundamental interest and relevance for chemistry in cold regions of the atmosphere. Here, the interactions of NO, NO2, N2O4, and N2O5 with ice surfaces at temperatures between 93 and 180 K are investigated with molecular beam techniques. Surface collisions are observed to result in efficient transfer of kinetic energy and trapping of mol
Importance: Prognostication of neurologic outcome after cardiac arrest is an important but challenging aspect of patient therapy management in critical care units. Objective: To determine whether serum neurofilament light chain (NFL) levels can be used for prognostication of neurologic outcome after cardiac arrest. Design, Setting and Participants: Prospective clinical biobank study of data from t
EXPLORING SOUND SOLASTALGIA The piece “Wave - exploring sound solastalgia” for the Sound Bench seeks to give sense and explore basic affects related to our sonically changing life worlds Nature sounds are often seen as relaxing, and understood as reconnecting our minds and bodies with something primeval. Such sounds are used for stress recovery in the fields of medicine and psychology, as well as
https://www.lmc.lu.se/en/sound-bench/wave - 2026-07-03
