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ICOS-ligand triggering impairs osteoclast differentiation and function in vitro and in vivo

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T

Systemic sclerosis. Novel molecular and epidemiological features of disease.

Popular Abstract in Swedish Systemisk skleros (SSc) är en relativt ovanlig reumatologisk sjukdom som kan engagera många av kroppens organ. Sjukdomen kallas ibland också för sklerodermi. Typiskt för sjukdomen är att huden omvandlas till fibros och blir hård och stram över olika delar av kroppen. Typiskt för sjukdomen är också att drabbade patienter har försämrad funktion i sina blodkärl, framförallSystemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. While lung involvement is a common cause of SSc-related death, a majority of SSc patients suffer from symptoms originating in the gastrointestinal (GI) tract. By combining data from a popu

Untitled

Untitled Master’s Dissertation Structural Mechanics JUAN CARDENAL BASTÉ Report TV SM -5150 JU A N C A RD EN A L BA STÉ D ESIG N M ETH O D FO R STR U T-B EA M C O N N EC TIO N IN H IN G ED FR A M ES DESIGN METHOD FOR STRUT-BEAM CONNECTION IN HINGED FRAMES Detta är en tom sida! Copyright © 2012 by Structural Mechanics, LTH, Sweden. Printed by Media-Tryck LU, Lund, Sweden, July, 2012 (Pl). For inform

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5150.pdf - 2026-05-23

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Jama prescott 2018 rv 170009

Enhancing Recovery From SepsisA Review Enhancing Recovery From Sepsis A Review Hallie C. Prescott, MD, MSc; Derek C. Angus, MD, MPH IMPORTANCE Survival from sepsis has improved in recent years, resulting in an increasing number of patients who have survived sepsis treatment. Current sepsis guidelines do not provide guidance on posthospital care or recovery. OBSERVATIONS Each year, more than 19 mil

https://www.sepsis.lu.se/sites/sepsis.lu.se/files/jama_prescott_2018_rv_170009.pdf - 2026-05-24

µHDS system for desulfurization of logistic fuels for fuel cell applications

Bränsleceller är ett intressant alternativ till förbränningsmotorer då bränsleceller har en högre effektivitet, är miljövänligare samt tystare. Bränslen som diesel, bensin samt det undersökta bränslet Jet A1, innehåller olika svårreagerade svavelföreningar. Problemet med bränslena är att de har ett relativt högt svavelinnehåll. Svavelföreningarna riskerar att förgifta katalysatorerna i de nedströ

Quality-policy-for-lund-university

Lägg till titel Page 1 of 1 REGULATORY DOCUMENT COVER PAGE Quality Policy for Lund University Type of regulatory document: Policy Definition of the type of regulatory document: Policies express the management’s overall intended direction or values that are to be taken into account within the area covered by the policy, set frameworks for a specific course of action and constitute a strong recommen

https://www.staff.lu.se/sites/staff.lu.se/files/2025-02/quality-policy-for-lund-university.pdf - 2026-05-24