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Antimicrobial peptides represent a heterogeneous group that displays multiple modes of action such as bacteriostatic, microbicidal and cytolytic properties that are sequence and concentration dependent. Life threatening infectious disease is now a worldwide crisis and treating them effectively is becoming difficult day by day, due to the emergence of antibiotic resistant strains at alarming rates.
Non-targeted effect of BCG: Several recent studies suggest that BCG has beneficial non-targeted effects on general child survival in low-income countries. Studies of the effect of BCG on morbidity in humans are scarce; some found a positive effect of BCG and others show no effect. Non-targeted effects of vaccines-possible bias and confounding: The major argument against comparing vaccinated and un
Recommendations stated in the TASC II guidelines for the treatment of peripheral arterial disease (PAD) regard a heterogeneous group of patients ranging from claudicants to critical limb ischaemia (CLI) patients. However, specific considerations apply to CLI patients. An important problem regarding the majority of currently available literature that reports on revascularisation strategies for PAD
Background: Osteoporosis is a common bone disease, which does not give symptoms until the ultimate outcome, the fragility fracture occurs. Regulation of bone mass is controlled by genetic, environmental and nutritional influences. Peak bone mass, defined as the maximum bone mass accrued, is usually reached by the third decade of life and is an important determinant of future osteoporotic fracture.
Popular Abstract in Swedish Immunsystemet skyddar kroppen mot infektion. För att kunna skydda mot infektion krävs att immunsystemet är utrustat med kraftfulla biokemiska motmedel. Ett sådant motmedel är antikroppar. Antikroppar är proteiner som känner igen och specifikt binder till andra molekyler via en s k molekylbindande klyfta. När antikropparna har bundit in till en molekyl på t ex en bakteriPrimary infections and vaccination stimulates the immunesystem to produce memory cells that rapidly respond to reexposure of the same antigen. These memory responses are dependent on an adaptive type of immunity that sustains the reactivity of the immune system by long-lived memory immune cells. From an evolutionary perspective adaptive immunity as such appears to be restricted to jawed vertebrate
Popular Abstract in Swedish Fåglars flygförmåga I alla tider har vi fascinerats av fåglars förmåga att flyga, och många försök att förstå och efterlikna dem har gjorts. Kanske den förste som på allvar intresserade sig för mekanismerna bakom fåglars flykt var Leonardo da Vinci som runt år 1500 funderade på hur fåglar alstrar lyftkraft. Leonardo skissade också på 100-tals maskiner som var tänkta atI share my fascination of bird flight with many others, and here I summarise my thesis on the subject. This thesis emphasises the mechanics of bird flight by focusing on flight mechanics, wake dynamics and flight performance. Gliding flight performance of a jackdaw was measured in a wind tunnel and I conclude that the current model for predicting optimum wingspan as a function of forward gliding
Breast cancer is the most common cancer among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated to investigate the joint effect of modifiable lifestyle factors on postmenopausal breast cancer risk. The study included 242,918 postmenopausal women from the multinational European Prospective Investigation into Cancer and Nut
Abstract in Uncoded languages Praegune kaitsejalatsite testimise standard (EN 344) kontrollib soojapidavuslikke omadusi vaid jalatsi ühes punktis, mõõtes temperatuuri muutust. Meetod, mis kasutab termilist jala mudelit, võimaldab mõõta jalatsi soojaisolatsiooni üheaegselt erinevates piirkondades ning ühtlasi ka jalatsi kui terviku soojaisolatsiooni. Selle uurimuse käigus arendati termilise jala mePresent standard on safety footwear (EN 344) checks the insulation only at one point in the shoes by means of measuring the temperature change. A method that uses thermal foot model allows to measure footwear insulation simultaneously at various locations and for whole footwear as well. In the present work the method of heated foot model was developed further. It is possible to simulate sweating a
Climate change and atmospheric aerosols are a threat for human health and life. Reducing aerosol emissions would save human lives close to the aerosol source, but could lead to more death due to the implications of a warmer climate. Aerosol particles acting as cloud or ice nuclei can induce a change in cloud properties and thus indirectly induce a change in planetary albedo, which is considered th
The cysteinyl-leukotrienes (cysLTs: LTC4, LTD4 and LTE4) have an important pathophysiological role in asthma. They are not only extremely potent bronchoconstrictors, but are also involved in the central mechanisms of the asthmatic inflammation and the subsequent remodelling of the airways. Allergen-induced bronchoconstriction as well as spontaneous exacerbations of asthma are associated with incre
Patients suffering from the progressive neurodegenerative disease Friedreich’s ataxia have reduced expression levels of the protein frataxin. Three major isoforms of human frataxin have been identified, FXN42-210, FXN56-210 and FXN81-210, of which FXN81-210 is considered to be the mature form. Both long forms, FXN42-210 and FXN56-210, have been shown to spontaneously form oligomeric particles stab
Popular Abstract in Swedish Sammanfattning Mänskliga aktiviteter och klimatförändringar påverkar vegetationen över hela jorden, idag och i framtiden. Denna påverkan kan studeras och kvantifieras med hjälp av observationer från satelliter vilka förmedlar information om vegetationsförändringar i tid och rum. I denna doktorsavhandling har metoder för analys av vegetationsförändringar utvecklats och Abstract This thesis aims to advance the analysis of nonlinear trends in time series of vegetation data from Earth observation satellite sensors. This is accomplished by developing fast, efficient methods suitable for large volumes of data. A set of methods, tools, and a framework are developed and verified using data from regions containing vegetation change hotspots. First, a polynomial-fittin
Popular Abstract in Swedish I Sverige och Norden har elproduktion traditionellt skett med huvudsakligen vattenkraft och kärnkraft. Detta håller dock på att förändras i takt med en allt större vindkraftsutbyggnad. Vindkraften skiljer sig i vissa avseenden från de traditionella produktionsslagen, ett av dessa är hur anslutningen till elnätet är utformad. Detta innebär att vindkraften, sedd från näteTraditionally the predominant generation has been large synchronous generators providing the system inertia. Nowadays when wind power and other non-synchronously connected units displaces this synchronous generation, the system inertia is reduced. Hence higher rate of change of frequency and larger frequency deviations are expected. This thesis deals with the impact on rate of change of frequency
The French court dress Le grand habit, worn at many European courts during the 18th century, was introduced in Sweden in the 1740’s by the crown princess Lovisa Ulrika, sister to Fredric II of Prussia. The robe de cour remained the official ceremonial dress for women at the Swedish court until Gustavus III launched the Swedish National Costume in 1778. The four robes de cour preserved in the Royal
Context. The HR 1614 is an overdensity in velocity space and has for a long time been known as an old (2 Gyr) and metal-rich ([Fe=H] +0:2) nearby moving group that has a dissolving open cluster origin. The existence of such old and metal-rich groups in the solar vicinity is quite unexpected since the vast majority of nearby moving groups are known to be young. Aims. In the light of new and signifi
During the last 10 to 15 years, an active line of research in proof complexity has been to study space complexity and time-space trade-offs for proofs. Besides being a natural complexity measure of intrinsic interest, space is also an important concern in SAT solving, and so research has mostly focused on weak systems that are used by SAT solvers. There has been a relatively long sequence of paper
Gadolinium-148 is one of the radionuclides of most concern that will be produced in the tungsten target of the European Spallation Source (ESS), as a by-product of the spallation reaction used by the facility to produce neutrons. Since 148Gd a pure alpha emitter, it is both very radiotoxic and difficult to measure. With its half-life of 75 years, it will remain in the environment for a long time i
AIMS/HYPOTHESIS: Prognostic factors and characteristics of children diagnosed with type 1 diabetes before 6 years of age were compared with those diagnosed at 6-13 years of age in the TEDDY study.METHODS: Genetically high-risk children (n = 8502) were followed from birth for a median of 9.9 years; 328 (3.9%) were diagnosed with type 1 diabetes. Cox proportional hazard model was used to assess the
Walking into Ftarri Records, I was surprised to find myself not in thepresent, but the past. The owner opened a box of AMM CDs from 1997,exclaiming gleefully, “Wow, these are really old. No-one will buy these –cool!”. Yet Toshimaru Nakamura played with an Eventide harmonizer pedalthat evening – something unimaginable in the starkly minimalist days theshop strove to emulate.In the 1990s, Boston Noi
The introduction of total prostate-specific antigen (tPSA) testing in serum has revolutionized the detection and management of men with prostate cancer. This review will highlight some of the exciting new developments in the field of prostate cancer screening in general and from our SPORE research program at Memorial-Sloan Kettering Cancer Center. First, it is important to understand that the inhe
