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Under appropriate conditions, neural tissues transplanted into the adult mammalian brain can survive, integrate, and function so as to influence the behavior of the host, opening the prospect of repairing neuronal damage, and alleviating symptoms associated with neuronal injury or neurodegenerative disease. Alternative mechanisms of action have been postulated: nonspecific effects of surgery; neur
Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell lines exhibit in vitro a develop
Establishing a solid chronological framework for Arctic marine sediments is a critical first step towards glacial and palaeoceanographic reconstructions. However, this has historically been more challenging than elsewhere in the world, and often results in core chronologies and subsequent paleoenvironmental reconstructions being questioned and overturned. Optically stimulated luminescence (OSL) da
Systems mixing Boolean logic and arithmetic have been a long-standing challenge for verification tools such as SAT-based bit-vector solvers. Though SAT solvers can be highly efficient for Boolean reasoning, they scale poorly once multiplication is involved. Algebraic methods using Gröbner basis reduction have recently been used to efficiently verify multiplier circuits in isolation, but generally
For decades, measured ice crystal number concentrations have been found to be orders of magnitude higher than measured ice-nucleating particle number concentrations in moderately cold clouds. This observed discrepancy reveals the existence of secondary ice production (SIP) in addition to the primary ice nucleation. However, the importance of SIP relative to primary ice nucleation remains highly un
Life-long production of blood from hematopoietic stem cells (HSC) is a process of strict modulation. Intrinsic and extrinsic signals govern fate options like self-renewal – a cardinal feature of HSC. Bone morphogenetic proteins (BMP) have an established role in embryonic hematopoiesis, but less is known about its functions in adulthood. Previously, SMAD-mediated BMP signaling has been proven dispe
The total heart volume variation (THVV) during systole has been proposed to be caused by radial function of the ventricles, but definitive data for both ventricles have not been presented. Furthermore, the right ventricle (RV) has been suggested to have a greater longitudinal pumping component than the left ventricle (LV). Therefore, we aimed to compare the stroke volume (SV) generated by radial f
1. In models of size-structured predator-prey systems, the effects are evaluated of gape-size limited predation on prey population growth and density when predators are non-interacting, cannibalistic, interfering, and cannibalistic and interfering. 2. Predation from non-interacting predators markedly reduces prey density, compared with prey densities in the absence of predation. When density-depen
A low intake of calcium is widely considered to be a risk factor for future fracture. The aim of this study was to quantify this risk on an international basis and to explore the effect of age, gender and bone mineral density (BMD) on this risk. We studied 39,563 men and women (69% female) from six prospectively studied cohorts comprising EVOS/EPOS, CaMos, DOES, the Rotterdam study, the Sheffield
Popular Abstract in Swedish Sjukdomar som drabbar hjärtats kranskärl och ger upphov till bland annat hjärtinfarkt är den vanligaste dödsorsaken både i Sverige och i resten av världen. Avsikten med denna avhandling är att ge en bild av livskvaliteten hos hjärtpatienter samt att ta upp problem inom medicinsk etik, som berör dessa patienter. Män och kvinnor som vårdats för hjärtinfarkt vid UniversiteOne month and one year after acute myocardial infarction (AMI) (n=296), coronary artery bypass grafting (CABG) (n=99) and percutaneous coronary intervention (PCI) (n=18) patients completed a questionnaire for self-assessment of quality of life (QoL) during the period 1989?1991. Patients differed from age- and sex-matched controls (n=88) in both somatic and emotional dimensions, but less after one
In this study, the use of light sheet fluorescence microscopic imaging is demonstrated for viewing the dynamic of atomizing sprays with high contrast and resolution. The technique presents several advantages. First, liquid fluorescence gives a more faithful representation of the structure of liquid bodies, droplets, and ligaments than Mie scattering does. The reason for this is that the signal is
The complete 1H NMR assignments have been obtained for five mutant proteins of calbindin D9k and the three-dimensional solution structures determined for two of the mutants. The structures have been determined using distance geometry and simulated annealing, with distance constraints from NMR. All mutants have modifications in the first calcium-binding site of calbindin (the N-terminal site design
Purpose: The purpose of this paper is to explain the “evaluation deadlock” or “stasis” diagnosed by many authors. The explanation relies on a thought experiment. Design/methodology/approach: The paper is conceptual and builds on a thought experiment inspired by qualitative research such as interviews with communication consultants in Sweden. It makes use of principal–agent theory and Akerlof’s the
Diffusion MRI may enable non-invasive mapping of axonal microstructure. Most approaches infer axon diameters from effects of time-dependent diffusion on the diffusion-weighted MR signal by modeling axons as straight cylinders. Axons do not, however, propagate in straight trajectories, and so far the impact of the axonal trajectory on diameter estimation has been insufficiently investigated. Here,
Ten square-based pyramidal molybdenum complexes with different sulfur donor ligands, that is, a variety of dithiolenes and sulfides, were prepared, which mimic coordination motifs of the molybdenum cofactors of molybdenum-dependent oxidoreductases. The model compounds were investigated by Mo K-edge X-ray absorption spectroscopy (XAS) and (with one exception) their molecular structures were analyze
Land remediation is an important part of restoration measures after a radioactive fallout containing long-lived fission products such as 137Cs. In this multidisciplinary study, we focused on three main issues related to remediation of contaminated urban areas. First, we assessed how much decontamination contributes to reducing resident radiation exposure and how much this reduction depends on the
Cardiovascular diseases (CVDs) remain a leading cause of death globally. According to the American Heart Association, approximately 19.1 million deaths were attributed to CVDs in 2020, in particular, ischemic heart disease and stroke. Several known risk factors for CVDs include smoking, alcohol consumption, lack of regular physical activity, and diabetes. The last decade has been characterized by
The significance of writing for PhD students, particularly at faculties of Humanities, cannot be overemphasized; the written manuscript is the final product to be publicly discussed by external examiners. This article takes as its starting point a “quick & dirty” study of a student-initiated writing group at a humanities department (HD) and the assumption that thesis supervisors nowadays need
Promoting longer lifetimes and efficient re-use of products has a significant potential to save resources and reduce adverse environmental impacts, especially for products that have large resource footprints related to extraction and production processes, as for instance automobiles. Remanufacturing is a product life extension strategy promoting the effective and efficient re-use of products by re
