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Parkinson’s disease is a neurodegenerative affliction to which researchers have long striven to find a cure. The human embryo is a source of vital cells used in regenerative medicine, as well as a powerful symbol of life. Using foetal cells from aborted embryos for transplantation to the brains of Parkinson patients is an avenue that has been explored by neuroscientists on and off for the last thi
Popular Abstract in Swedish För mer än hundra år sedan visade Hofmeister och Lewith att vissa salter har mer eller mindre förmåga att destabilisera ett protein upplöst i vatten. Ungefär samtidigt, visade Arrhenius att salter upplösta i vatten dissocierar i olika joner. Joner är laddade stabila partiklar som är mycket viktiga för stabiliteten av kemiska och biologiska system. Det har under de senasUsing experiments it is rather easy to measure things on the macroscopic length scale, while it is much harder to measure something in the microscopic world like molecular structure. The opposite is true in theoretical chemistry. It is today rather easy to calculate a bond distance or a coordination number, but it is not possible to perform a calculation aiming at the description of macroscopic ph
This thesis deals primarily with the production of written texts by adults with reading and writing difficulties. Their writing is analysed from three different aspects: error analysis, non-error-oriented text analysis and analysis of the production process. These studies are based on data from on-line recordings of writing. The main question is how the written language production of adults with r
Management scholars have long separated the study of opportunity creation and discovery, assuming that the nature of opportunities itself is not affected by information acquisition. Research on judgment and decision-making challenges this assumption, confirming that we judge the nature of opportunities in large part by the way we acquire information about it. Management theorists have yet to diges
This dissertation deals with memory, recognition and solidarity in the Nowa Huta district of Kraków, Poland. Nowa Huta was founded as an independent, socialist model town in 1949, together with the large Lenin Steel Plant, and was incorporated into Kraków in 1951. In the 1980s the steel plant and district became one of the main centers of the oppositional Solidarity movement in Poland. Situated be
Radical energy efficiency improvements are needed to keep global warming within 1.5 °C until the end of the century. Minimum energy performance standards (MEPS) are a widely applied policy instrument to improve the energy efficiency of appliances and reduce CO2 emissions, but they are criticized as redundant if an overarching carbon pricing scheme is in place. In order to better understand how MEP
Improving urban liveability and prosperity is commonly set as a priority in urban development plans and policy around the world. Several annual reports produced by international consulting firms, media, and global agencies rank the liveability of cities based on a set of indicators, to represent the quality of life in these cities. The higher is the ranking, the more liveable is the city. In this
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that
The building industry is facing a huge challenge as the industry sector carries much responsibility of the anthropogenic climate change: activities associated with housing alone account for as much as 30% of global annual energy demand. This demand derives not only from the physical characteristics of the buildings, but from the actions of the users, both end-users and professional managers. Even
The chief aim of this thesis is to investigate the use of language called poetry during the second half of the 20th century and how the writing subject is implicated in it. Building on the theoretical perspectives enabled by Michel Foucault’s late work on the technologies of the self, I analyze the practices of writing in John Ashbery’s, Inger Christensen’s and Yves Bonnefoy’s poetry. The introduc
Some species of long-distance migrant birds are thought to follow spatiotemporal patterns of high food availability during the non-breeding season, a strategy termed "itinerancy," instead of being sedentary in one specific site. We tracked the migration of a small Eurasian songbird, the Common Redstart (Phoenicurus phoenicurus), using archival light-level geolocators. The birds showed a distinct c
In this work, we studied cobalt nitride (Co-N) thin films deposited using a dc magnetron sputtering method at a substrate temperature (Ts) of 523 K. We find that independent of the reactive gas flow (RN2 ) used during sputtering, the phases of Co-N formed at this temperature seems to be identical having N at.% ∼ 5. This is contrary to Co-N phases formed at lower Ts. For example at Ts∼ 300 K, an ev
Best use of scientific knowledge is required to maintain the fundamental role of seafood in human nutrition. While it is acknowledged that genomic-based methods allow the collection of powerful data, their value to inform fisheries management, aquaculture, and biosecurity applications remains underestimated. We review genomic applications of relevance to the sustainable management of seafood resou
Aim. This article is a report on a descriptive study of fathers' experiences of providing their preterm infants with Kangaroo Mother Care. Background. During neonatal intensive care, fathers describe the incubator as a barrier and the separation from their infant as stressful. Fathers consider it important to be close to the infant, and performing Kangaroo Mother Care makes them feel an important
Most migrating birds need to stopover in between flights in order to refuel. Lately, additional purposes of stopover have been suggested, including physiological recovery from metabolically demanding migratory flight. One apparently unavoidable, but harmful physiological effect of migratory flight is increased oxidative damage to lipids and proteins. We here, for the first time, tested whether mig
Diverse organisms use Earth's magnetic field as a cue in orientation and navigation. Nevertheless, eliciting magnetic orientation responses reliably, either in laboratory or natural settings, is often difficult. Many species appear to preferentially exploit non-magnetic cues if they are available, suggesting that the magnetic sense often serves as a redundant or 'backup' source of information. Thi
We demonstrate the use of Light Sheet Fluorescence Microscopic (LSFM) imaging for viewing the dynamic of atomizing sprays with high contrast and resolution. The technique presents several advantages: first liquid fluorescence gives a more faithful representation of the structure of liquid bodies, droplets and ligaments than Mie scattering does. The reason for this is that the signal is emitted by
A major pathological hallmark of Parkinson’s disease (PD) is a severe degeneration of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNc) projecting to the motor part of the striatum. Therefore, there is a long-standing interest in using animal models with severe nigrostriatal degeneration for experimental research. Pathophysiological and behavioral features of PD are best
Pleiotropy (multiple phenotypic effects of single genes) and epistasis (gene interaction) have key roles in the development of complex phenotypes, especially in polymorphic taxa. The development of discrete and heritable phenotypic polymorphisms often emerges from major-effect genes that interact with other loci and have pleiotropic effects on multiple traits. We quantified gene expression changes
BACKGROUND: Myocardial and coronary endothelial injury occurs in donor hearts due to warm ischemia during cardiac transplantation. Coronary endothelial structure and function play a critical role in long-term outcomes for patients after cardiac transplantation. OBJECTIVE: To study the effect of hypoxia-induced warm ischemia (20 minutes) on coronary endothelial function of porcine donor hearts afte
