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The Src-Like Adaptor Protein (SLAP) is an adaptor protein sharing considerable structural homology with Src. SLAP is expressed in variety of cells regulating receptor tyrosine kinase signaling by direct association. In this report, we show that SLAP associates with both wild-type and oncogenic c-Kit (c-Kit-D816V). The association involves SLAP SH2 domain and receptor phosphotyrosine residues diffe
Mesenchymal stromal cells (MSC) are increasingly used as an investigative therapeutic product for immune disorders and degenerative disease. Typically, MSC are isolated from human tissue, expanded in culture and cryopreserved until usage. The safety and efficacy of MSC therapy will depend on the phenotypical and functional characteristics of MSC. The freeze-thawing procedure may change these chara
P>Aims Impaired sensory function in the sole of the foot in diabetic patients is a substantial problem caused by unknown mechanisms. Hand or foot sensibility can be improved by cutaneous anaesthesia of the forearm or lower leg, respectively, in healthy subjects. Hypothetically, cutaneous anaesthesia induces a silent area in the primary somatosensory cortex, allowing adjacent cortical areas to expa
Soil nitrogen (N) availability constrains future predictions of ecosystem primary productivity and carbon storage. The progressive N limitation (PNL) hypothesis predicts that forest net primary productivity (NPP) will decline with age, and that the response of NPP to elevated CO2 will attenuate through time due to negative feedbacks of NPP on the soil N cycle. A central assumption of the PNL hypot
Injury to the peripheral nerves in the upper extremity results in changes in the nerve, and at multiple sites throughout the central nervous system (CNS). We studied the long-term effects of an injury to the median nerve in the forearm with a focus on changes in the CNS. Four patients with isolated injuries of the median nerve in their 20s were examined a mean of 14 years after the injury. Cortica
This paper focuses on the use of Life Cycle Assessment (LCA) to evaluate the performance of seventeen control strategies in wastewater treatment plants (WWTPs). It tackles the importance of using site-specific factors for nutrient enrichment when decision-makers have to select best operating strategies. Therefore, the LCA evaluation is repeated for three different scenarios depending on the limita
Malignant melanoma (MM) patients are being treated with an increasing number of personalized medicine (PM) drugs, several of which are small molecule drugs developed to treat patients with specific disease genotypes and phenotypes. In particular, the clinical application of protein kinase inhibitors (PKI) has been highly effective for certain subsets of MM patients. Vemurafenib, a PKI targeting BR
Popular Abstract in Swedish Bindväv är samlingsnamnet på de vävnader som bygger upp ben, brosk, senor, ligament, tänder, hud m.m. Bindväven utgör kroppens stomme och bidrar med stödjande och elastiska funktioner samt ger skydd åt kroppen både på utsidan och åt de inre organen. Det finns ganska få celler i bindväv jämfört med många andra vävnader i kroppen och det finns olika celltyper i olika sortThe properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. We have studied the role of collagen-binding extracellular matrix leucine-rich repeat glycoproteins/proteoglycans in the forma
Most bacteria are likely to face osmotic challenges, but there is yet much to learn about how such environmental changes affect the architecture of bacterial cells. Here, we report a cell-biological study in model organisms of the genus Streptomyces, which are actinobacteria that grow in a highly polarized fashion to form branching hyphae. The characteristic apical growth of Streptomyces hyphae is
Intraspecific female aggression during the breeding season can have several different functions: defence of resources, defence against intraspecific brood parasitism and defence of mating status. The intraspecific aggressive behaviour of breeding female starlings, Sturnus vulgaris, was examined by exposing them to a simulated intrusion of a conspecific bird. A caged male or female starling was pla
Ytan av alla celler är dekorerad med kolhydrater som står för mycket av den information en cell överför till omgivande celler. Många av kolhydraterna tillhör en föreningsklass som kallas proteoglykaner som består av ett protein sammanbundet med en eller flera långa kolhydratkedjor. Dessa kolhydratkedjor kallas glykosaminoglykaner och är bundna till proteinet via kolhydraten xylos. Än så länge har β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of
We present progress in the development of artificial photosynthesis, as a means to harvesting and storage of solar energy. The plan is to compose molecular systems that combine known photochemistry with emerging functional model compounds. A photochemical device for solar energy conversion contains a photosensitizer, an electron acceptor system and a donor system that prevents charge recombination
Immunoglobulin kappa promoters were collected from mice and man. It was shown that they had homology within but not between subgroups, and the promoters were also conserved between species. The octamer element was found in all promoters, but other sequence elements were conserved within the distinct subgroups. E-boxes were found in most promoters and were usually of the E2A type. A mouse kappa pro
Skogar har en positiv inverkan på halten av växthusgaser i atmosfären eftersom de binder koldioxid via fotsyntesen och lagrar kol i marken. Dessutom utgör många skogar en betydande sänka för växthusgasen metan. Upptaget av metan sker i väl syresatta marker genom oxidation utförd av metanotrofa bakterier. Däremot sker en nettoproduktion av metan i syrefattiga skogsmarker när mikroorganismer, s.k. aPopular Abstract in English Forests have a positive impact on the level of greenhouse gases in the atmosphere because they absorb carbon dioxide through photosynthesis and store carbon in the soil. Moreover, many forests function as a sink for the greenhouse gas methane (CH4). The uptake of CH4 takes place in well-aerated soils through oxidation by methanotrophic bacteria. However, there is a net
Sensor based control systems increase flexibility and autonomy in robotics. One of the most common applications in robotics is welding, which is often limited to objects with fine tolerances. To be able to manage objects with relatively large tolerances, such as ship-hulls, sensor guided control systems have to be incorporated that are able to handle large deviations from the drawings. To be able
We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp). Microbial surfacebound C4bp demonstrated cofactor activity. We constructed gonococcal strains with hybrid porin (Por) molecules derived from each of the major serogroups (Por1A and Por1B)
Electron transfer (ET) of ligninolytic peroxidases was studied in the bioelectrocatalytic reduction reaction of H2O2 at peroxidase-modified graphite electrodes. Specifically, native lignin (LiP) and manganese (MnP) peroxidases secreted by Phanerochaete chrysosporium, as well as a few different recombinant MnP forms were used in the electrochemical studies. The recombinant enzymes included wild-typ
Wind speed and direction have a significant effect on a flying bird's ground speed. Migrants are therefore expected to be sensitive to wind conditions and this should have consequences for optimal strategies of stopover and refuelling. Based on an earlier model of time-minimizing migration which includes wind condition, we investigate the consequences of the temporal correlation of wind conditions
Blood coagulation factor V (FV) is a 330 kDa plasma glycoprotein. Activated FV (FVa) is a non-enzymatic cofactor to activated Factor X in the activation of prothrombin that occurs during coagulation. To investigate the molecular mechanisms of the quantitative FV deficiency associated with the FV R2 haplotype (a common genetic variant in several populations), four missense mutations identified in
