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A novel mutation, a C to T transition at base pair 2124 in exon 17 of the amyloid beta-protein precursor (APP) gene, has been identified by direct sequencing of amplified DNA from two Alzheimer's disease (AD) patients. A simple oligonucleotide-hybridization procedure was developed to allow population studies of this DNA variation. The mutation, which is silent at the protein level, was present in
Popular Abstract in Swedish Fasoxidbränsleceller (eng. SOFC) är en keramisk bränslecellstyp som arbetar vid höga temperaturer. Genom att utnyttja energin hos avgaserna från en SOFC i en annan kraftvärmeprocess kan man erhålla ett s.k. hybridsystem som når höga verkningsgrader. Ett koncept som studerats i denna avhandling är en SOFC i kombination med en gasturbincykel (SOFC/GT). Eftersom bränslecelSolid oxide fuel cells (SOFCs) are a ceramic type of fuel cell operating at elevated temperatures. By utilising the thermal energy from the SOFC in a heat engine, a hybrid cycle with high performance can be achieved. One promising concept is a pressurised SOFC in combination with a recuperated gas turbine cycle. The fuel cell, being the more efficient power generator of the two, represents the maj
Introduction. An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic brain injury. The group is also working towards the creation of an open access, detailed and validated database that will be useful for post-hoc hypothesis testing. In Part A, the underlyin
Methane emissions from Northern wetlands constitute a substantial part of the total natural emission of methane, a strong greenhouse gas. Both environmental and biotic factors influence the production, oxidation and transport of methane and hence its net flux. The methane emission from Northern wetlands is highly variable both spatially and temporally. As many factors influence the methane flux, k
While calls to reduce air travel have emerged in many high-income countries, Nepal, with only one international airport, is still striving to improve its air connectivity. In 2015, the government resumed its 1995 plan to build a second international airport near Nijgadh, a town in the southern plains. The project has since come under scrutiny from conservationists after plans emerged for extensive
Från år 2021 ska alla nybyggnationer i Europa vara nära-nollenergibyggnader. Detta innebär att byggnaders energianvändning bör vara låg och i mycket hög grad tillförs i form från förnybara energikällor som produceras på plats eller i närheten. Syftet med de höga energikraven är att påskynda takten för att skapa ett mer energieffektivt byggande. Den minskade energianvändningen tillsam-mans med en ö
Background: Systemic amyloidosis (SSA) is a common form of amyloidosis but it remains often unnoticed because of the slow progression in old patients. The cause for SSA is the accumulation of wild-type transthyretin amyloids in critical tissues. We provide here data showing that SSA may be associated with old-age non-Hodgkin lymphoma.Systemic amyloidoses include immunoglobulin light chain (AL) amy
Popular Abstract in Swedish Denna sammanläggningsavhandling i fysisk planering visar hur viktig rättens och juridikens roll är för planeringen och styrning av landskap och miljö, och de fall som studerats och analyserats är den svenska utbyggnaden av 3G-infrastruktur och vindkraften. Utifrån ett rättssociologiskt planeringsperspektiv visar Stefan Larsson (som också disputerat i rättssociologi tidiThis PhD thesis in Spatial Planning argues for the importance of understanding the approaches to knowledge and rationalities embedded in spatially relevant decision-making. It emphasises the significance of seeing law as an empirical object of study for planning and environmental management. The Swedish development of wind power and 3G mobile infrastructures are used as cases to study these issues
The structural approach to credit risk modeling has gained a growing attention in both the academics and in the industry. In this dissertation, we outline the basic ideas and structures of the KMV (Merton) model and also explain some related issues before implementing this model. Referring to the KMV model, we use the KMV model to identify the credit risk of listed companies in China. We use real
We report a new design of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. Acoustic trapping enables nanoparticle and exosome enrichment without the need for ultracentrifugation. The commercial acoustic trapping technology, AcouTrap (AcouSort AB), typically operates at flow rates < 50 μl/min which limits processing of larger
BACKGROUND: Malignant melanoma is the most deadly form of skin cancer. Female sex is known to have a protective effect on incidence, tumour characteristics, and mortality from melanoma. However, the potentially modifying effect of sex on the prognostic significance of clinicopathological and investigative factors is generally not taken into consideration in biomarker studies. In this study, we com
BackgroundRectal washout (RW) is performed to eliminate intraluminal cancer cells and thereby reducing the risk of local recurrence (LR). The overall aim of this thesis was to investigate the importance of RW in rectal cancer surgery.MethodPaper I: Survey of the current practice of RW among Swedish colorectal units.Paper II: The association between RW and 30-day postoperative complications after a
In this study, we modeled the aerosol particle formation along air mass trajectories arriving at the remote Arctic research stations Gruvebadet (67 m a.s.l.) and Zeppelin (474 m a.s.l.), Ny-Ålesund, during May 2018. The aim of this study was to improve our understanding of processes governing secondary aerosol formation in remote Arctic marine environments. We run the Lagrangian chemistry transpor
East Prussia was a region populated by people of many different ethnoses, confessions and languages. Initially settled by Germans after the Teutonic Knights had conquered native Pruthenians, it quickly became a melting pot of newcomers from different regions of Europe.East Prussian diversity took a serious hit after the unification of Germany in 1871. The homogenisation policies adopted by the aut
With a national prevalence of 4.9% in the adult population, the HIV-1 epidemic in Kenya is the fifth largest in the world. HIV-1 prevalence is more than three-fold higher among HIV key populations – including men who have sex with men (MSM), people who inject drugs (PWID), and female sex workers (FSW) than in the general heterosexual (HET) population. However, the contribution of different risk gr
Spatial decision making is an everyday activity, common to individuals and organizations. However, recently there is an increasing interest in the importance of spatial decision-making systems, as more decision-makers with concerns about sustainability, social, economic, environmental, land use planning, and transportation issues discover the benefits of geographical information. Many spatial deci
The fate of soil organic matter (OM) is determined by its microbial use for growth or respiration. Many environmental factors influence microbial OM use, including the presence of contaminants and toxins in the environment, such as heavy metals. We evaluated short- and long-term responses of microbial processes to metal contamination by estimating biomass concentrations and growth rates of bacteri
IMPORTANCE: Although occupational balance (OB) is a construct of importance to occupational therapy, existing OB assessments have not been validated in clinical populations. OBJECTIVE: To examine the validity and reliability of the 11-item version of the Occupational Balance Questionnaire (OBQ11) in U.S. adults with Type 1 diabetes. DESIGN: Data were analyzed from adults with Type 1 diabetes enrol
AbstractSevere perineal trauma (SPT) is a serious complication following vaginal birth. To reduce its incidence rate, various preventive strategies have been implemented in Swedish obstetric units. Collegial midwifery assistance (CMA), involving an additional midwife being present during the active second stage of labour, is a clinical practice that was evaluated in the Oneplus trial, which proved
