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The average life expectancy for large companies on the fortune 500 list has declined rapidly since the 1950s. One major reason is the growing competition from new actors on the market. Innovation has become one of the most important competencies for companies to get ahead of the competition. The growing demand for companies to be innovative and at the same time operate their core business have dee
På Volvo Construction Equipments produktionssite i Braås tillverkas olika varianter av dumprar. Produktionen på siten ligger i framkant men i ett av produktionsavsnitten har det inte skett några förändringar på många år. Uppdraget var därför att ta fram ett underlag till ledningen för möjliga investeringar samt förbättringar inom produktionsavsnittet. I uppdraget ingick även att undersöka hur en mAt the Volvo Construction Equipment site in Braås, different kinds of articulated haulers are being produced. The production is in the forefront of its kind but one of the sections of the production has not seen any changes in many years. This thesis aims to present a decision basis to Vovlo for future investments and how the section should develop their future work. The thesis also aims to presen
The city of Chennai evolved around the river, Cooum. The river supports irrigation to agricultural fields in the north and supplies water to the city of Chennai. It also acts as a major flood carrier for the city. Before the 1960s, the river was clean and used for activities such as bathing, boating and fishing. During the colonial rule, the city was initially planned to sustain a much lesser popu
Animals monitor environmental ques by translating them into electrical signals through a depolarization of the electric potential over the cell membrane of nerve cells. A way to initiate the depolarization is through activation of receptors that are ion channels. These channels can facilitate the diffusion ions across membranes driven by the differences in concentration and electrical charge on ea
Uppsatsen utreder när en person som arbetar hemifrån i Sverige men är anställd på ett bolag beläget utomlands kan medföra att ett fast driftställe uppstår. Mer specifikt undersöks det när hemarbete kan skapa ett fast driftställe vid tillämpningen av OECD:s modellavtal i den nationella rätten. Uppsatsens syfte är även att systematisera gällande rätt mot bakgrund av den senaste tidens rättsutvecklinThis thesis aims to investigate when teleworking creates a permanent establishment for a person working at home, in their personal residence in Sweden, but are employed by an enterprise established abroad. Specifically, the thesis studies when teleworking constitutes a permanent establishment during treaty application of OECD’s Model Tax Convention under Swedish domestic law. The purpose is also t
Galectin-1 is a member of the carbohydrate-binding protein family galectins. Galectins are involved in the immune system. However, in cancer growth, galectin-1 is overproduced to not make the immune system respond. Therefore, inhibitors of the protein were synthesized to make the immune system approach the cancer and respond. From previous studies and simulations on the computer program Maestro di
The world continues to boil due to capital’s incapacity to resolve its climatic contradictions. Stratospheric Aerosol Injection (SAI), a technological process theorised to instantly reduce global temperatures, has piqued the interest of a now desperate ruling class. Given its worldwide impacts, enormous risks, and capitalist- imperialist reproductive capacities, it is crucial to engage with SAI wh
Gene flow in macroalgal populations can be strongly influenced by spore or gamete dispersal. This, in turn, is influenced by a convolution of the effects of current flow and specific plant reproductive strategies. Although several studies have demonstrated genetic variability in macroalgal populations over a wide range of spatial scales, the associated current data have generally been poorly resol
This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. We found that C-C Motif Chemokine Ligand 2 (CCL2) secreted from mesothelial cells is a dominant chemokine promoting the peritoneal dissemination
Aim: To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods: Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI
Coordinated international censuses of the Northwest European Bewick's Swan Cygnus columbianus bewickii population have been undertaken across the swans' wintering range at c. 5-year intervals since 1984. During the early years of the study, numbers increased steadily to a peak of 29,780 individuals in January 1995, but then declined by 39.4% to 18,057 swans counted in January 2010 before showing a
Polycyclic aromatic hydrocarbons (PAHs) are produced by anthropogenic activities, such as traffic and domestic heating. Due to their adverse effects to humans and natural habitats, the presence of PAHs in the environment needs to be monitored. Plants are known as natural accumulators of persistent organic pollutants (POPs) and can therefore be used for the monitoring of PAHs emitted into the envir
Nitrate pollution in groundwater is a serious problem in Shimabara Peninsula, Nagasaki, Japan. A better understanding of the hydrogeochemical evolution of groundwater in vulnerable aquifers is important for health and environment. In this study, groundwater samples were collected at 12 residential and 57 municipal water supply wells and springs in July and August 2018. Nitrate (NO3-N) concentratio
Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more vulnerable in the earlier stages of the disease. Taking advantage of recent developments in ultra-high field (7 T) imaging, we investigated whether imaging measures of the LC also reveal a specific anatomic correlation
This study presents indoor and outdoor levels of airborne fine particles (PM2.5), particle bound polycyclic aromatic compounds (PACs) including parent-, alkylated-, nitro-, and oxy-PAHs. Week-long simultaneous measurements were conducted inside and outside 15 occupied homes in southern Sweden during wintertime. The homes were single-family houses or apartments located in urban, semi-urban, and rur
We have calculated redox potentials of the two metal clusters in Mo-nitrogenase with quantum mechanical (QM) calculations. We employ an approach calibrated for iron–sulfur clusters with 1–4 Fe ions, involving QM-cluster calculations in continuum solvent and large QM systems (400–500 atoms), based on structures from combined QM and molecular mechanics (QM/MM) geometry optimisations. Calculations on
Motivation: Most protein-structure superimposition tools consider only Cartesian coordinates. Yet, much of biology happens on the surface of proteins, which is why proteins with shared ancestry and similar function often have comparable surface shapes. Superposition of proteins based on surface shape can enable comparison of highly divergent proteins, identify convergent evolution and enable detai
Soil erosion has created landscape problems in many parts of the world and in particular in cold regions where the sensitive permafrost conditions have changed due to climate warming. Such a case occurred in the Tibetan Plateau (TP), which has been strongly affected by global warming and human activities. Monitoring technologies, like remote sensing and field surveys were used to explore soil eros
