Filetype
Induction of the mitochondrial permeability transition (MPT) has been implicated in cellular apoptosis and in ischemia-reperfusion injury. During MPT, a channel in the inner mitochondrial membrane, the mitochondrial megachannel, opens and causes isolated mitochondria to swell. MPT and mitochondrial swelling is inhibited by cyclosporin A (CsA), which may also inhibit apoptosis in some cells. Treatm
We report the first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541 [N-[[1-(3-bromo-phenyl)-eth-(E)-ylidene-hydrazinocarbonyl]- (4-oxo-3,4-dihydro-phthalazin-1-yl)-methyl]-benzamide] and AC-264613 [2-oxo-4-phenylpyrrolidine-3-carboxylic acid [1-(3-bromo-phenyl)-(E/Z)- ethylidene]-hydrazide], each representing a distinct chemical series. AC-55541 and AC-264613 each activated P
The use of Alcohol-based antiseptics is efficient and approved, however it has some limitations. This paper examined the possibility of using hypochlorite water as a chlorine-based antiseptic for handwashing in public buildings and healthcare facilities. The electrolysis method was used, which produces Hypochlorous acid (HOCl) from mixing drinking water with small amounts of sodium hydroxide. Hypo
Semi-natural grasslands are characterized by high fine-scale plant species richness. The richest grassland communities, with many habitat-specialist species, are found in ancient grassland sites that have a long continuity of grazing management and low levels of soil nutrients. Grazed grasslands were widespread in the historical landscape. Agricultural intensification over the last two centuries h
Color guides many important behaviors in birds. Previously we have shown that the intensity threshold for color discrimination in the chicken depends on the color contrast between stimuli and their brightness. The birds could discriminate larger color contrasts and brighter colors in lower light intensities. We suggested that chickens use spatial summation of cone signals to maintain color vision
The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the prot
To obtain an electron-density map from a macromolecular crystal the phase problem needs to be solved, which often involves the use of heavy-atom derivative crystals and concomitant heavy-atom substructure determination. This is typically performed by dual-space methods, direct methods or Patterson-based approaches, which however may fail when only poorly diffracting derivative crystals are availab
We have characterized a putative Ca(2+)-ATPase from the pathogenic bacterium Listeria monocytogenes with the locus tag lmo0841. The purified and detergent-solubilized protein, which we have named Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1), performs a Ca(2+)-dependent ATP hydrolysis and actively transports Ca(2+) after reconstitution in dioleoylphosphatidyl-choline vesicles. Despite a high sequ
The pseudorapidity density of charged particles, dNch/dη, at midrapidity in Pb-Pb collisions has been measured at a center-of-mass energy per nucleon pair of sNN=5.02 TeV. For the 5% most central collisions, we measure a value of 1943±54. The rise in dNch/dη as a function of sNN is steeper than that observed in proton-proton collisions and follows the trend established by measurements at lower ene
Most of the decisive molecular events in biology take place at the protein-water interface. The dynamical properties of the hydration layer are therefore of fundamental importance. To characterize the dynamical heterogeneity and rotational activation energy in the hydration layer, we measured the 17O spin relaxation rate in dilute solutions of three proteins in a wide temperature range extending d
We analysed the relative importance of individual versus institutional factors in explaining variations in the utilisation of physician services among the 50+ in ten European countries. The importance of the latter was investigated, distinguishing between organisational (explicit) and cultural (implicit) institutional factors, by analysing the influence of supply side factors, such as physician de
Objective: To develop calculation models, using Western immunoblot, as a tool for the estimation of proteolytic human aggrecan fragment identity. Method. Seven human aggrecan fragments (calibrators), purified by CsCl gradient centrifugation and identified by Western immunoblot of N- and C-terminals, were used to develop calculation models. The models were used for identification of unknown aggreca
Popular Abstract in Swedish Övergödningen av Östersjön är fortfarande ett problem. Förhöjda krav på kvävereduktion för de svenska avloppsreningsverken är därför att vänta. Detta innebär i sig ökad energi- och kemikalieförbrukning, vilket rimmar illa med ord som energieffektivisering och resurssnålhet. Biologisk kväverening av en specifik delström på reningsverket har dock potential att minska ytbeEnhanced biological nitrogen removal at municipal wastewater treatment plants is a common procedure to prevent eutrophication in water bodies. Increased load, stricter effluent regulations, and demands for reduced resource and energy consumption present new challenges for the wastewater treatment plants. One option when upgrading a wastewater treatment plant is to treat the sludge liquor produced
Sammanfattning Aktiv eutanasi och assisterat självmord är två frågor som tidvis dyker upp i den allmänna debatten i Sverige. Det är dock få politiker som vill ta i frågan, detta trots att en betydande del av det svenska folket är positivt inställda till att tillåta aktiv eutanasi. Genom åren har ett antal rättsfall berört frågan om aktiv eutanasi men rättsläget över vissa typer av aktiv eutanasi äSummary Active euthanasia and assisted suicide are two issues that from time to time appear in the Swedish public debate. It is however few politicians that want to bring up the issues, in spite of that a considerate part of the Swedish population have positive attitude to legalise active euthanasia. Through the years a number of cases have addressed the issue about active euthanasia but the legal
Alfa Laval DC Lund is both a spare part manufacturer and distributer. The spare parts that Alfa Laval DC Lund supplies are used for the heat transfer business unit of Alfa Laval. Sometimes orders need to be produced fast as customers may have breakdowns in production and sometime orders arrive months earlier than customers want to receive delivery as scheduled services occur at the customer. Probl
Ocean acidification is a consequence of the anthropogenic release of carbon dioxide (CO2) to the atmosphere. When CO2 is dissolved in water it affects the composition of ions and lowers the pH of the water. As the partial CO2 pressure in the atmosphere increases a new balance is reached with the surface waters which causes the pH of the surface oceans to decrease. For small shallow seas this effec
Ecological rehabilitation projects - as a form of reforestation interventions - are increasing worldwide and present an opportunity for climate change mitigation and supporting local livelihoods. Implemented in post-conflict situations, they are increasingly promoted as solutions for peace. Aiming at understanding their contributions to sustainability and peacebuilding, I examine proposed rehabili
Background: Little is known about how parental gender equality early in their children lives can influence daughters’ decision to use contraceptive pills. Aim:The study aimed at exploring whether maternal working time and paternity leave in Sweden during the first two years of their daughters’ lives is associated with the use of oral contraceptives when they are adolescents or young adults. Materi
Equitable distribution of healthcare services towards the reduction of HIV-AIDS prevalence in Nigeria remains a major public health concern. One of several research model to solve this public health problem is the use Geographical Information System, a two-step floating catchment area (2SFCA), this model emerged in the last decade as a key measure of spatial accessibility, particularly in its appl
