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A rich palaeospinacid selachian fauna, comprising 1141 isolated teeth, has recently been collected from the latest Early Campanian strata ofthe Kristianstad Basin. Four palaeospinacid species have been found: Synechodus perssoni nov.sp., Synechodus lerichei Herman 1977, Paraorthacodus andersoni (Case 1978) and Paraorthacodus conicus (Davis 1890). The recovered material suggests that only ontogenet

The European Spallation Source, now under construction in Lund, Sweden, aims to be the world's most powerful pulsed neutron scattering facility. Driving the neutron source is a 5 MW superconducting proton linear accelerator operating at 4 percent beam duty factor and 14 Hz repetition rate. Nineteen partner institutions from across Europe are working with the Accelerator Division in Lund to design

Designing appropriate control systems for radiant heating and cooling terminals entails an understanding of their dynamic behaviour. This study experimentally investigates the dynamic response of a room with convective and radiant cooling systems. The experiments were performed in a 12.6 m2 large test room outfitted as a single-office room. The main cooling system was radiant ceiling panels which

A novel Ets protein was isolated by yeast one-hybrid screening of a cDNA library made from lipopolysaccharide-stimulated mouse splenic B cells, using the SP6 κ promoter κY element as a bait. The novel Ets protein was most closely related to PU.1 and Spi-B within the DNA binding Ets domain and was therefore named Spi-C. However, Spi-C may represent a novel subgroup within the Ets protein family, as

Food is a major concern in popular culture and in literary studies at present and there are numerous novels, movies, and TV-shows that focus on food and its various functions – literary, cultural, and social. Food, which is a highly politicised subject, is one way in which cultural translation takes place as it is used to create an understanding of cultural transfer processes and their implication

As indicated in several earlier chapters in this anthology, traffic safety data are of many different types and studied in a large number of different activities. Many professional studies make use of already existing data, such as accident data records from police, insurance companies and hospitals, as well as statistical data derived from such databases. Other data are collected for specific pur

Deep metabarcoding offers an efficient and reproducible approach to biodiversity monitoring, but noisy data and incomplete reference databases challenge accurate diversity estimation and taxonomic annotation. Here, we introduce a novel algorithm, NEEAT, for removing spurious operational taxonomic units (OTUs) originating from nuclear-embedded mitochondrial DNA sequences (NUMTs) or sequencing error

Layered lithium-rich transition metal oxides are promising cathode candidates for high-energy-density lithium batteries due to the redox contributions from transition metal cations and oxygen anions. However, their practical application is hindered by gradual capacity fading and voltage decay. Although oxygen loss and phase transformation are recognized as primary factors, the structural deteriora

Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms, which are upregulated in numerous cancers, making the enzyme an attractive drug target. Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures.

Enzymes with a protein kinase fold transfer phosphate from adenosine 5'-triphosphate (ATP) to substrates in a process known as phosphorylation. Here, we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host-cell calmodulin to polyglutamylate the SidE family of ubiquitin (Ub) ligases. Crystal structu

Conductive Electric Road Systems (ERS) appear as a promising solution for the electrification of transportation, particularly for heavy vehicles and long-distance trips but also for light vehicles. Significant research efforts are currently devoted to the development of conductive ERS systems, with up to four pilot test sites with different technologies in operation only in Sweden. With the help o

Gender assignment in languages with a gender system is a complex issue, as this can be influenced by both semantic, morphological, and phonological factors (Corbett, 1991, 2013; Corbett & Fraser, 2000). Many Indo-European languages possess a three-gender system, which distinguishes masculine, feminine, and neuter gender. Whereas this system is preserved in several Indo-European branches, it ha

Aims. We seek to provide abundances of a large set of light and neutron-capture elements homogeneously analyzed that cover a wide range of metallicity to constrain globular cluster (GC) formation and evolution models. Methods. We analyzed a large sample of 885 GCs giants from the SDSS IV-Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. We used the Cannon results to separate

Background: Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners’ (GPs) advice to stop statins in oldest-old patients. Objective: To investigate the influence of a history of CVD, statin-related side effects, frailty and short life expectancy, on G

The first great ruler to encourage the adoption of Western culture and technology throughout Siam was King Narai, who also had a passion for astronomy. He showed this by encouraging French and other Jesuit missionaries, some with astronomical interests and training, to settle in Siam from the early 1660s. One of these was Father Antoine Thomas, and he was the first European known to have carried o

BACKGROUND: Machine learning (ML) is an emerging tool for predicting need of end-of-life discussion and palliative care, by using mortality as a proxy. But deaths, unforeseen by emergency physicians at time of the emergency department (ED) visit, might have a weaker association with the ED visit.OBJECTIVES: To develop an ML algorithm that predicts unsurprising deaths within 30 days after ED discha

Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the