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Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt at their 3' end, and moreover that the 3' end of miR-21 is po

The aim of the following study is to examine the legal status in Sweden in relation to Onlyfans as well as examining social norms surrounding the platform. The questions at issue regard Onlyfans and the content that creators sell there, in relation to the social norms regarding prostitution. This study also reviews how the content on Onlyfans could be interpreted as selling sexual services in acco

Gender equality has become a top priority worldwide. However, gender tends to be synonymous with women and the agency of men is too often marginalised in both development interventions and research. Previous studies have found that as men are not included in the Gender and Development paradigm a “crisis of masculinity” is occurring which implies that sustainable gender equality will be more diffic

Mobile applications are today an important way for companies to reach their customers. Developing a mobile application could require a lot of resources, especially if the application is to be made from scratch. However, an alternative for a company with an existing web application, is making use of the logic in the existing web application, to create a hybrid mobile application. In this thesis, tw

Denna uppsats baserar sig på en utredning av Försäkringskassan, som presenterades i maj 2005. Titeln var Utredning om könsneutralt och delat barnbidrag. Försäkringskassan hade fått i uppdrag av regeringen att utreda förutsättningarna för att göra lagstiftningen kring barnbidraget könsneutral och införa en möjlighet för föräldrarna att kunna dela bidraget mellan sig. Den nuvarande barnbidragslagsti

We have characterised the interchain emitting states of two substituted polyfluorenes with steady-state and time-resolved photoluminescence (PL). Site selective excitation of the interchain state shows that physical dimers are formed in the film. These dimers have low concentration in the films but exciton diffusion to the dimers is reducing the intrachain exciton lifetime. With asymmetrical subst

In order to calculate building energy usage, apart from the technical characteristics, user related factors needs to be determined. Unless the user related factors are determined by specific project, the idea is to apply a standardized list of input data for a normal operation during a normal year, so the calculated energy value does not depend on variation of these factors. Such list was issued b

World electricity consumption is drastically increasing. One of the most common ways of producing electricity is to use the chemical energy of fossil fuels. This can be done in thermal power plants in which the chemical energy of fossil fuels such as natural gas is converted to mechanical energy and finally to electricity. Extracting the chemical energy of fuels is done through combustion of the

Focal adhesions are force sensitive structures that dynamically alter their composition, protein-protein interactions, and signaling in response to external mechanical stimuli. These dynamic changes are critical for focal adhesion function and are required for cellular mechanosensing. Here, we describe a simple protocol that allows for isolation of the focal adhesion complex from adherent cells in

The focal and progressive degeneration of dopaminergic (DA) neurons in ventral midbrain has made Parkinson's disease (PD) a particularly interesting target of cell-based therapies. However, ethical issues and limited tissue availability have so far hindered the widespread use of human fetal tissue in cell-replacement therapy. DA neurons derived from human pluripotent stem cells (hPSCs) offer unpre

Joubert syndrome and related disorders (JSRD) are clinically and genetically heterogeneous ciliopathies sharing a peculiar midbrain-hindbrain malformation known as the 'molar tooth sign'. To date, 19 causative genes have been identified, all coding for proteins of the primary cilium. There is clinical and genetic overlap with other ciliopathies, in particular with Meckel syndrome (MKS), that is al

Microbial communities play a major role in the degradation of soil organic matter (SOM) in soils. Despite its significance, the functional diversity of the highly diverse microbial communities is poorly understood. To address this, we applied a recently developed technique, captured metagenomics, to determine the effects of land-use on the functional genetic diversity of genes involved in the carb

Popular Abstract in Swedish Ökad förståelse för hjärtats pumpfunktion är av stort intresse för att kunna förbättra diagnostik, behandling och prognoser för hjärtsjuka patienter. Blodflöde i hjärtat är direkt kopplat till hjärtats form och rörelse och kan därför vara en viktig markör för hjärtats funktion. Därför var målet med denna avhandling att utveckla och förbättra mätningar av blodflöde med hIncreased understanding of the pumping mechanics of the heart are of great importance to develop diagnostics, treatment and prognostics for cardiovascular diseases. Blood flow in the heart is connected to its anatomy and function, and may therefore be a sensitive marker of cardiac health and disease. Therefore, the aim of this thesis is to develop and validate methods for quantification and visual

Gene and protein expression is controlled so that cells can react to changing intra- and extracellular signals by modulating biochemical networks and pathways. We have previously shown that gene expression and the properties of expressed proteins are dynamically correlated. Here we investigated correlations between gene related parameters and gene expression patterns, and found statistically signi

Accurate imputation is essential for the reliability and success of downstream tasks. Recently, diffusion models have attracted great attention in this field. However, these models neglect the latent distribution in a lower-dimensional space derived from the observed data, which limits the generative capacity of the diffusion model. Additionally, dealing with the original missing data without labe

Aim: The aim of this study was to investigate the annual prevalence and characteristics of Paediatric Feeding Disorder (PFD) in Västerbotten county, Sweden, during the years 2012–2022. Methods: In this retrospective study, medical records of patients attending paediatric clinics with possible feeding problems were identified by applying pre-defined diagnostic and procedure codes. Diagnostic criter