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The antibody response to the envelope proteins of hepatitis C virus (HCV) may play an important role in controlling the infection. To allow molecular analyses of protective antibodies, we isolated human monoclonal antibodies to the E2 envelope glycoprotein of HCV from a combinatorial Fab library established from bone marrow of a chronically HCV-infected patient. Anti-E2 reactive clones were select

The reactions between three sphalerite samples and ethyl- and n-decylxanthate ions have been studied in aqueous and acetone solutions. Qualitative analysis of the species present on the sphalerite surfaces before and after treatment with these ions have been performed by means of diffuse reflectance infrared Fourier transform spectroscopy. Atomic absorption spectrophotometry has been used to deter

The objective of this paper is to investigate how the combustion chamber design will influence combustion parameters and emissions in a natural gas SI engine. Ten different geometries were tried on a converted Volvo TD102 engine. For the different combustion chambers emissions and the pressure in the cylinder have been measured. The pressure in the cylinder was then used in a one-zone heat-releas

Plasma autoantibodies (aAbs) against the oxidized DNA base derivative 5-hydroxymethyl-2'-deoxyuridine (5-HMdU) are potential biomarkers of cancer risk and oxidative stress. We examined their association with a number of cancer risk factors: smoking, alcohol habits, body fatness, and absence of the glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) in a sample from the population-based Malmö Di

This thesis aims to find algorithms for optimal control of hybrid systems and explore them in sufficient detail to be able to implement the ideas in computational tools. By hybrid systems is meant systems with interacting continuous and discrete dynamics. Code for computations has been developed in parallel to the theory. The optimal control methods studied in this thesis are global, i.e. the ent

Dispersal is of prime importance for many evolutionary processes and has been studied for decades. The reproductive consequences of dispersal have proven difficult to study, simply because it is difficult to keep track of dispersing individuals. In most previous studies evaluating the fitness effects of dispersal, immigrants at a study locality have been lumped into one category and compared to ph

Popular Abstract in Swedish Ehrlichia hos människor och djur Fästingburna infektioner uppmärksammas alltmer både hos människor och djur. Fästingar har visat sig kunna överföra flera olika infektiösa agens som till exempel borrelia- och ehrlichiabakterier, tick-borne encephalitis (TBE)-virus och babesia-parasiter. De i Skandinavien förekommande ehrlichia-bakterierna Ehrlichia phagocytophila, orsakEhrlichia phagocytophila is a tick-borne pathogen of domestic animals, which has recently been acknowledged also as a human pathogen. It is a strictly intracellular bacterium, infecting granulocytes of the host, sometimes resulting in clinical disease - granulocytic ehrlichiosis - with manifestations ranging from mild flu-like conditions to severe infections with multi-organ failure and death. Thi

Popular Abstract in Swedish För att skydda sig mot infektioner har människan ett välutvecklat immunförsvar. I immunförsvaret ingår många olika celler och proteiner (äggviteämnen). Till exempel finns det celler som producerar antikroppar som specifikt känner igen bakterier och virus som en människa har utsatts för vid en tidigare infektion. Det finns också speciella celler som kan fagocytera (äta uMany microorganisms have developed mechanisms to protect themselves against attack from the complement system of the host. One possible mechanism for a microorganism to evade complement attack is to bind a human complement regulator, which may allow the microorganism to down-regulate complement activation. This thesis describes studies of such interactions between human C4b-binding protein (C4BP),

Syftet med denna undersökning var att bestämma en 1 kg isvästs kylverkan på kroppen vid brandmansarbete. Testerna genomfördes i en klimatkammare, i en container med extrem strålningsvärme och i ett rökdykningshus med värme och tungt arbete. Den faktiska kylverkan mättes också med en termisk docka. Fyra erfarna brandmän deltog i försöken. I alla tester bar försökspersonerna standardklädsel för branThe aim of the present study was to examine the effects of wearing a light-weight ice-vest (1kg, water) on physiological and subjective responses in fire fighter’s work. The experiments were carried out in a climatic chamber, in a container under extreme radiant heat, and during simulated smoke-diving. In addition, the physical cooling effect of the ice-vest was measured with a thermal mannequin.

Aim Heart transplantation (HTx) has become a standard treatment for patients with end-stage heart disease. The aim of this study was to report the long-term outcome after HTx in Scandinavia. Methods and results During the period, 1983-2009,2333 HTxs were performed in 2293 patients (mean age 45 +/- 16 years, range 0-70,78% mate). The main indications for HTx were non-ischaemic cardiomyopathy (50%),

Moraxella catarrhalis is an emerging human-restricted respiratory tract pathogen that is a common cause of childhood otitis media and exacerbations of chronic obstructive pulmonary disease in adults. Here, we report the first completely assembled and annotated genome sequence of an isolate of M. catarrhalis: strain RH4, originally isolated from blood of an infected patient. The RH4 genome consists

ObjectiveHematopoietic stem cell transplantation (HSCT) is curative in several life-threatening pediatric diseases but may affect children and their families inducing depression, anxiety, burnout symptoms, and post-traumatic stress symptoms, as well as post-traumatic growth (PTG). The aim of this study was to investigate the co-occurrence of different aspects of such responses in parents of childr

Macroarray analysis was used to compare equal amounts of cDNA from wild-type and rd/rd (retinal degeneration) mice, collected at P90 when photoreceptor degeneration is virtually complete. A stronger signal for the glycolytic enzyme phosphoglucose isomerase (Gpi1) was observed in the rd/rd sample. Extracellularly, Gpi1 may act as a cytokine, independently described as neuroleukin and autocrine moti

Background Impaired activation of the human skeletal muscle glycogen synthase by insulin is typical for type 2 diabetic patients. Regulation of glycogen synthase occurs mainly by phosphorylation/dephoshorylation but little is known whether there also is transcriptional regulation. Therefore we studied transcriptional regulation of the human skeletal muscle glycogen synthase gene (GYS1) and evaluat

The results are presented of a detailed plant macrofossil analysis of a C-14 dated Holocene organic sequence from a sub-Antarctic island, South Georgia. In the peat infilling of a rock basin 31 bryophyte species and many of the principal species of the present-day angiosperm flora, associated with bog communities, have been identified. The zonation of the bryophytes and the seeds and fruits shows

Orientation experiments were performed with first-year snow buntings (Plectrophenax nivalis) during their autumn migration in a natural near-vertical geomagnetic field approximately 400 km away from the magnetic north pole. Migratory orientation of snow buntings was recorded using two different techniques: orientation cage tests and freeflight release experiments. Experiments were performed under

Although many effects of gamma-aminobutyric acid (GABA) on retinal function have been attributed to GABA(A) and GABA(C) receptors, specific retinal functions have also been shown to be mediated by GABA(B) receptors, including facilitation of light-evoked acetylcholine release from the rabbit retina (Neal and Cunningham [1995] J. Physiol. 482:363-372). To explain the results of a rich set of experi

Sixteen open-top chambers (diameter, 3.66 m) were established in a scrub oak habitat in central Florida where vegetation was removed in a planned burn prior to chamber installation. Eight control chambers have been continuously exposed to ambient air and eight have been continuously exposed to elevated CO2 at twice-ambient concentration (similar to700 ppm) for 5 years. Soil cores were collected fr

The effect of Phytophthora species, soil chemistry, precipitation and temperature on the vitality of oak was evaluated in 32 oak stands in southern Sweden. In addition, the relationship between the occurrence of Phytophthora species and soil conditions was determined. The results showed that there was a weak association between the presence of P. quercina, the most frequently recovered Phytophthor