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Background We aimed to accurately estimate the frequency of a hexanucleotide repeat expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Methods We screened 4448 patients diagnosed with ALS (El Escorial criteria) and 1425 patients with FTD (Lund-Manchester criteria) from 17 regions worldwide for the

This article examines the records of the so-called homo-sex commission—a part of the municipal Stockholm police force dedicated to the policing of male same-sex practices—as a case study of the role of policing in shaping historical understandings of homosexuality. Building on a series of documents left by the commission and high-ranking police officers, from memoranda describing the nature of hom

We report the first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541 [N-[[1-(3-bromo-phenyl)-eth-(E)-ylidene-hydrazinocarbonyl]- (4-oxo-3,4-dihydro-phthalazin-1-yl)-methyl]-benzamide] and AC-264613 [2-oxo-4-phenylpyrrolidine-3-carboxylic acid [1-(3-bromo-phenyl)-(E/Z)- ethylidene]-hydrazide], each representing a distinct chemical series. AC-55541 and AC-264613 each activated P

En stor del av narkotikaförsäljningen sker idag via internet och distribueras genom det nationella postflödet där köpare inte sällan får hem försändelserna direkt i sin brevlåda. Mot bakgrund av detta föreslår 2021 års postlagsutredning (SOU 2021:29) ökade möjligheter för de brottsbekämpande myndigheterna att förhindra denna illegala handel. Utredningen föreslår bland annat att ge personal inom poA vast amount of drug sales take place daily via the internet and is distributed through the national postal system, where buyers often receive the items to their mailbox. Considering this, the Swedish Government appointed a new Committee to review the duty of confidentiality in the Postal Services Act (2010:1045) in order to increase opportunities for the law enforcement authorities to prevent th

Construction sites are key points regarding implementing robot supervision to create more secure, reliable, and free hand-work workspaces. This project’s scope is to develop a complete interpretation of a modern concept of surveillance. For this case, the test scenario is the industrial lab at the Faculty of Engineering, Lund University, known as RobotLab. For its development, an Augmented Reality

It is very common that business transactions, in particular internationally, are made through agents. It is therefore interesting and clearly relevant to be aware of the diversities in the agency laws of different countries. The major differences between the Swedish agency law on the one hand and the English and American on the other hand are encountered when focusing on how authority can be estab

Runt om i den Europeiska unionen (EU) utnyttjas den fria rörligheten i större utsträckning än tidigare. Företag flyttar över nationsgränserna och med företagen kommer arbetstagarna och deras familjer. Idag sträcker sig allt fler familjeband över nationsgränserna och i och med det har också familjerätten tagit steget från att ha varit nationell till att bli allt mer internationell. Inom EU finns Within the European Union (EU), the freedom of movement guaranteed in the Treaties has increased significantly the last decade. Companies may move their establishment from one Member State to another and with the companies, the employees and their families follow. An effect of the integration within the European Union is a high level of cross-border family relationships. As a result, family law ha

Om dina ögon vore lika känsliga som astronomers toppmoderna teleskop skulle du kunna se långa band av ljus när du kollar upp mot himlen. Dessa band kallas stjärnströmmar och befinner sig i yttre delen av våran galax, Vintergatan. Strömmarna skapas från en klump av stjärnor, t.ex. en dvärggalax, medan de roterar runt Vintergatan. Det som händer är att stjärnor slits loss från klumpen och dras ut tiThe orbital approximation for stellar streams is the assumption that all stars in a stream can be described as following the same orbit. In this thesis, I evaluate this approximation as a method for constraining the potential of the Milky Way. I wrote a program in MATLAB which integrates the orbits of test particles in a potential model which resembles that of the Milky Way's halo and disc. Th

Boendet har en stark koppling till äldres livskvalitet. Utformningen av äldres boendemiljö är viktig då de spenderar mycket tid i och i nära anslutning till boendet. Boendemiljön påverkar hur trygg den boende känner sig där exempelvis hala golv eller dålig belysning kan skapa en känsla av otrygghet. Sveriges befolkning ökar och antalet invånare över 65 väntas öka från 1,9 miljoner 2014 till 3 milThe living environment has a strong connection with elderly's quality of life. The design of the elderly housing environment is important as they spend a lot of time in and near their home. The housing environment affects how safe the residents feel, for example slippery floors or poor lighting can create an insecurity. Sweden's population is increasing and the population of those over 65

Equitable distribution of healthcare services towards the reduction of HIV-AIDS prevalence in Nigeria remains a major public health concern. One of several research model to solve this public health problem is the use Geographical Information System, a two-step floating catchment area (2SFCA), this model emerged in the last decade as a key measure of spatial accessibility, particularly in its appl

The threat of potentially catastrophic climate change has led to 195 countries pledging to keep global average temperature rise well below 2°C based on pre-industrial levels. Wind energy technology has developed to a point where it can make a significant contribution to meeting this objective. A number of countries have developed substantial wind energy networks in recent years which in turn has a

Läkemedelsindustrin är beroende av patent. Rätten till patent möjliggör de nödvändiga investeringar i forskning och utveckling som krävs för att utveckla nya läkemedel och få ut dessa på marknaden. Detta gynnar både konsumenter och samhället i stort. De största läkemedelsföretagen investerar i forskning och utveckling, och är därmed de primära innehavarna av läkemedelspatent. Samtidigt som de störThe pharmaceutical industry is dependent on the granting of patents. Patents make it possible for pharmaceutical companies to invest in the necessary R&D to bring new drugs to the market. This benefits consumers and the health care sector at large. The biggest pharmaceutical companies invest in R&D, and as a result are the major holders of pharmaceutical patents. While the big pharmaceutic

The High-Intensity Baryon Extraction and Measurement experiment (HIBEAM) is proposed as one of the experimental stations at the European Spallation Source (ESS). This experiment will mainly focus on the neutron into sterile neutron oscillations which violate the baryon number (B) by one unit. The sterile neutrons are hypothetical dark matter candidates. The neutrons suitable for the experiment hav

Den 1 juli 2020 infördes ett nytt regelverk gällande rapporteringspliktiga arrangemang i Sverige och i samband med detta infördes även en uppgiftsskyldighet att lämna uppgifter om rapporteringspliktiga arrangemang till Skatteverket. För att ett arrangemang ska vara rapporteringspliktigt ska det vara gränsöverskridande samt innehålla minst ett kännetecken. Ett kännetecken är en egenskap i ett arranOn the July 1, 2020, a new framework of rules regarding reportable arrangements was introduced in Sweden and at the same time a reporting obligation to give information about reportable arrangements to the Swedish Tax Agency (STA) was introduced. For an arrangement to be reportable it must be cross-border and include at least one hallmark. A hallmark is a characteristic in an arrangement which is

Hormone-mediated maternal effects play an important role in the formation of a differentiated phenotype. They have been shown to influence a wide array of offspring traits, both early in life and in adulthood. One important offspring trait that is under the influence of maternal androgens is the immune system. In birds, a growing number of studies show that yolk androgens modulate immune function