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In a revision of the stratigraphic classification of the subsurface Upper Ordovician succession of Gotland, the terms Lower and Upper Ostersjo Limestone are rejected and replaced by the Slandrom Limestone and the File Limestone, respectively. Two mound generations are recognized, the Rakveran-Nabalan Liste mounds and the Pirguan Klasen mounds, the latter being by far the most common. Both occur no
Background: Interferon beta-1a (IFNbeta-1a; Avonex) is effective for the treatment of relapsing MS; however, the optimal dose of IFNbeta-1a is not known. Objective: To determine whether IFNbeta-1a 60 mug IM once weekly is more effective than IFNbeta-1a 30 mug IM once weekly in reducing disability progression in relapsing MS. Methods: In a double-blind, parallel-group, dose-comparison study, 802 pa
Popular Abstract in Swedish Gangesfloden i Varanasi (Indien) anses samtidigt vara fullkomligt ren och svårt förorenad, beroende på vem som definierar dess egenskaper, brahminska religiösa specialister eller vetenskapligt orienterade miljöaktivister. Medan kontroversen fortgår, försöker några hinduiska religiösa ledare att anpassa sina traditioner till de nya miljöparadigmen, och deras förhållningsWhether the Ganges river in Varanasi (India) is pristinely pure or heavily polluted depends on by whom it qualities are defined, the Brahmin religious specialists in the city or the science oriented environmentalists. While the controversy continues, some Hindu religious leaders are searching for ways to adjust their respective traditions to the environmental paradigms, an initiative that reflects
This study examines the attempts made by one local government in China, Shenzhen, to improve its investment environment for foreign-invested enterprises through administrative reforms between 1980 and 1997. Three empirical questions are posed: what reforms have been undertaken, what effects have they had and how have changes in the organizational environment affected them. The theoretical aim is
Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance
Surface exposed cysteines were genetically engineered in the structure of recombinant horseradish peroxidase (rHRP). Recombinant forms of HRP with either a His-tag or a Strep-tag at the C-terminus were produced, which additionally had cysteines at positions 57, 189 or 309 (C-terminus) of the polypeptide chain. An E coli expression system was exploited. The effect of these mutations on the direct e
Vi människor och vårt samhälle påverkas mycket av klimatet vi lever i och av de naturliga klimat- och miljövariationer som sker på jorden. Det kan vara kortvariga katastrofartade händelser som tsunamis och jordbävningar men också långsammare och långvariga klimatförändringar som påverkar vårt sätt att leva och bruka jorden. Genom geologiska studier av jordens historia vet vi att klimatet har varieNightingale Island is situated at 37°S in the central part of the South Atlantic Ocean, which is a sensitive location for variations within the Atlantic Meridional Overturning Circulation (AMOC) and the Southern Hemisphere Westerlies (SHW) wind belt. A peat sequence from the wetland 2nd Pond has been investigated with emphasis on the composition of the deposits, loss on ignition (LOI), total Carbo
Popular Science Summary Konsten att kunna ta bort ett syre Alla celler har DNA, som måste repareras och kopieras för att livet ska fortgå. För att kunna göra detta måste det finnas byggstenar. En av alla processer som ser till att alla delar finns i rätt mängd innefattar bara ett protein. Ett protein som får instruktioner från många håll för att gå igenom en komplicerad process som tillverkar dessThe protein ribonucleotide reductase catalyses the de novo synthesis of deoxyribonucleotides (dNTPs) from ribonucleotides (NTPs), using radical chemistry. It is under strict allosteric regulation, partly from the dNTPs it synthesises that regulate what substrate should be synthesised, but also from dATP/ATP, which regulates overall activity. It is a protein that is found in almost every living org
The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat
Aims. "Earthshine" is the dim light seen on the otherwise dark side of the Moon, particularly when it is close to new. "Earthlight", or reflected sunlight from the Earth, is the source of Earthshine. Using B and V band CCD images of both the dark and bright sides of the Moon, we aim to estimate the Johnson photometry B V colour of the Earthshine for the first time since the late 1960s. From these
This paper considers the problem of finding the cost of a quickest path between two points in the Euclidean plane in the presence of a transportation network. A transportation network consists of a planar network where each road (edge) has an individual speed. A traveler may enter and exit the network at any point on the roads. Along any road the traveler moves with a fixed speed depending on the
We study how the results of molecular dynamics (MD) simulations are affected by various choices during the setup, e.g., the starting velocities, the solvation, the location of protons, the conformation of His, Asn, and Gln residues, the protonation and titration of His residues, and the treatment of alternative conformations. We estimate the binding affinity of ligands to four proteins calculated
Today, there is considerable interest in integrated forest biorefineries which, besides pulp, produce high-value-added products, such as, polymers and carbon fibres. Lignin is the major non-cellulosic constituent of wood. It is a complex, amorphous highly crosslinked polyphenolic. Lignosulphonate in spent liquor in sulphite mills has long been isolated using ultra filtration. Generally, precipitat
The detrimental effects of increased length of stay at the emergency department (ED-LOS) for patient outcome have been sparsely studied in the Swedish setting. Our aim was to further explore the association between ED-LOS and short-term mortality in patients admitted to the EDs of two large University hospitals in Sweden. All adult patients (> 18 years) visiting the ED at the Karolinska University
BACKGROUND: During the last 5 years, there has been an increase in the use of unicompartmental knee arthroplasty (UKA) to treat knee osteoarthritis in Australia, and these account for almost 6% of annual knee replacement procedures. However, there is debate as to whether a fixed bearing or a mobile bearing design is best for decreasing revision for loosening and disease progression as well as impr
Apolipoprotein A-I (ApoA-I) is the major protein constituent of high-density lipoprotein particles, and as such is involved in cholesterol transport and activation of LCAT (the lecithin:cholesterol acyltransferase). It may also form amyloidal deposits in the body, showing the multifaceted interactions of ApoA-I. In order to facilitate the study of ApoA-I in various systems, we have developed a pro
This work presents a data-driven model to simulate the mechanical behavior of the breast tissues in real time. The aim of this model is to speed up some multimodal registration algorithms, as well as some image-guided interventions. Ten virtual breast phantoms were used in this work. Their deformation during a mammography was performed off-line using the finite element method. Three machine learni
Summary: Vertebral fractures are independent risk factors for vertebral and nonvertebral fractures. Since vertebral fractures are often missed, the relatively new introduction of vertebral fracture assessment (VFA) for imaging of the lateral spine during DXA-measurement of the spine and hips may contribute to detect vertebral fractures. We advocate performing a VFA in all patients with a recent fr
Early airway responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are of interest since they could decide whether coronavirus disease-19 (COVID-19) will proceed to life-threatening pulmonary disease stages. Here I discuss endothelial-epithelial co-operative in vivo responses producing first-line, humoral innate defence opportunities in human airways. The pseudostrati
