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Treatment of met-myoglobin (Fe-III) with H2O2 gives rise to ferryl myoglobin, which is closely related to compound II in peroxidases. Experimental studies have given conflicting results for this species. In particular, crystallographic and extended x-ray absorption fine-structure data have shown either a short (similar to170 pm) or a longer (similar to190 pm) Fe-O bond, indicating either a double
In NW Patagonia, Argentina, poor regeneration after fires of Nothofagus pumilio (Poepp. and Endl.) Krasser forests located in drier environments has been attributed to probable edaphic changes. We studied the long-term effects of wildfire on the mineralogical, physical, chemical and biological properties of a soil developed from volcanic-ashes under N. pumilio forests. Soils from six small patches
Models based on generalized plant physiological theory represent a promising approach for describing vegetation responses to environmental drivers on large scales but must be tested for their ability to reproduce features of real vegetation. We tested the capability of a generalized vegetation model (LPJ-GUESS) to simulate vegetation structural and compositional dynamics under various disturbance
Surface exposed cysteines were genetically engineered in the structure of recombinant horseradish peroxidase (rHRP). Recombinant forms of HRP with either a His-tag or a Strep-tag at the C-terminus were produced, which additionally had cysteines at positions 57, 189 or 309 (C-terminus) of the polypeptide chain. An E coli expression system was exploited. The effect of these mutations on the direct e
Popular Abstract in Swedish Den danska riksbildningen presenteras vanligen som en linjär process som knyter ihop forntida hövdingar med den moderna nationalstaten. Avhandlingen fokuserar de små berättelserna bortom den stora berättelsen om Danmark. Avhandlingen argumenterar för att den tidigare forskningen kring den danska riksbildningen kan delas in i tre huvudlinjer: 1. Den danska riksbildningeThe formation of the kingdom of Denmark is generally presented as a linear process linking ancient chiefs to the modern nation state of Denmark. This dissertation focuses on the small stories behind this great narrative of Denmark. The purpose is to show that there never was any formation process. Instead, encounters between people in the local landscapes and the Danish kingdom were both considera
Alkaline sphingomyelinase (alk-SMase) is a new member of the NPP (nucleotide pyrophophatase/phosphodiesterase) family that hydrolyses SM (sphingomyelin) to generate ceramide ill the intestinal tract. The enzyme may protect the intestinal mucosa front inflammation and tumorigenesis. PAF (platelet-activating factor) is a pro-inflammatory phospholipid involved in pathogenesis of inflammatory bowel di
BACKGROUND: S100A7 is a calcium-binding protein with chemotactic and antimicrobial properties. S100A7 protein levels are decreased in nasal lavage fluid from individuals with ongoing allergic rhinitis, suggesting a role for S100A7 in allergic airway inflammation. The aims of this study were to describe genetic variation in S100A7 and search for associations between this variation and allergic rhin
Background— Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF. In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF assessed by analysis of fibrillatory rate of the atria. Methods and R
Background-Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF assessed by analysis of fibrillatory rate of the atria. Methods and Resu
Large-scale studies are essential to assess the emission patterns and spatial distribution of organohalogenated pollutants (OHPs) in the environment. Bird eggs have several advantages compared to other environmental media which have previously been used to map the distribution of OHPs. In this study, large-scale geographical variation in the occurrence of OHPs, such as polychlorinated biphenyls (P
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene a
Background: Parkinson's disease (PD) is a neurodegenerative disease that leads to progressive disability. Cost studies have mainly explored the early stages of the disease, whereas late-stage patients are underrepresented. Objective: The aim is to evaluate the resource utilization and costs of PD management in people with late-stage disease. Methods: The Care of Late-Stage Parkinsonism (CLaSP) stu
The processes responsible for methane (CH4) emissions from boreal wetlands are complex; hence, their model representation is complicated by a large number of parameters and parameter uncertainties. The arctic-enabled dynamic global vegetation model LPJ-GUESS (Lund-Potsdam-Jena General Ecosystem Simulator) is one such model that allows quantification and understanding of the natural wetland CH4 flu
Smittspridningen av viruset COVID-19 i början av år 2020 innebar att stater blev tvungna till att vidta restriktioner som lett till stängning av många skolor och bibliotek. Trots nedstängning, har skolor i Sverige kunnat fortsätta undervisningar digitalt. Det finns dock upphovsrättsliga utmaningar med digitala undervisningar, med anledning av upphovsmannens ensamrätt. Syftet med uppsatsen är att uThe outbreak of COVID-19 in the beginning of 2020 has led to states imposing restrictions that cause many schools and libraries to close. Despite the lockdown, it has been possible for schools in Sweden to continue their lectures digitally. However, there are copyright issues to address in the transition to digital teaching because of the right holder's exclusive rights to his or her works. Th
Finite resources and increasing rate of consumption have made efficiency a key component in every energy consuming sector. The building industry, as a major contributor, has been the target of various initiatives and regulations aiming to lower its impact with varying degrees of success. Measurement of this impact has not always been easy, especially for buildings not yet built. Therefore, simulat
Under början av 2000-talet växte konceptet Responsibility to Protect (R2P) fram i syfte att stärka skyddet för befolkningar i vissa särskilt utsatta situationer. Genom konceptet skulle det internationella samfundet åläggas en skyldighet att skydda människor. Konceptet har dock sedan dess tillkomst kritiserats flitigt i den internationella debatten och har fortfarande inte uppnått rättslig status. During the beginning of the 21st century, the concept of Responsibility to Protect (R2P) emerged with the purpose of strengthening the protection of populations at certain risk. Through the concept, the international community was supposed to carry a responsibility to protect human beings. However, the concept has been highly criticized in the international debate ever since its foundation and has
The goal of this thesis project was to develop an energy surveillance system for the Swedish production industry. The main problem this project sought to solve is that several Swedish industries are currently only able to measure the energy consumption of their entire facilities, as one big black box. They cannot determine the energy consumption of the individual machines within each and every pro
Att tvångsomhänderta ett barn är ett undantag från svensk inställning att vård ska ske genom frivillighet. Det är inget som görs lättvindigt och det krävs att det finns en påtaglig risk för att barnets hälsa eller utveckling annars kommer till skada. Men hur stora krav finns det i samband med vårdens avslutande, var ligger fokus när den bedömningen görs? Syftet med detta arbetet är att titta på föTo take a child into public care against the parents will is an exception from the Swedish standpoint that all care should be given on a voluntary basis. It requires that there is a noticeable risk that the child's health or development will come to harm. But what are the demands when deciding whether the care should come to an end? Where is the focus in that process? The aim of this study is
I Sverige råder en allmän medborgerlig skyldighet att inställa sig som vittne i domstol och där avlägga vittnesmål. Denna skyldighet träffar, med några få undantag, den som av ett eller annat skäl anses inneha information av betydelse för målet. Vittnesmålen är av oerhörd betydelse för att våra domstolar ska ges möjlighet att komma till korrekta avgöranden. Problematiskt är dock hur vittnen många In Sweden, there is a general civil obligation to appear in court as witness and to testify. With a few exceptions, this obligation affects anyone who is considered to possess important information to a case. Testimonies such as these form the basis for the courts to make correct rulings. However, there is a problem related to the many witnesses who are afraid to fulfil their obligations and who i
Dissolved organic carbon (DOC) plays an essential role in the biogeochemistry and ecology of surface waters by influencing carbon cycle and microbial respiration. DOC is related to CO2 emissions from inland waters that can be compared to emissions of peatlands and DOC decay is influenced by environmental factors. Traditional methods used to measure DOC decay do not account for environmental factor
