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Cartilage matrix protein (CMP) is a trimeric protein present in many types of cartilage extracellular matrix. It has recently been purified under native conditions that allowed the proposal of a structural model (Hauser, N., and Paulsson, M. (1994) J. Biol. Chem. 269, 25747-25753). To examine the functional properties of CMP we studied its interaction with aggrecan within cartilage extracellular m
Xanthorhodopsin of the extremely halophilic bacterium Salinibacter ruber represents a novel antenna system. It consists of a carbonyl carotenoid, salinixanthin, bound to a retinal protein that serves as a light-driven transmembrane proton pump similar to bacteriorhodopsin of archaea. Here we apply the femtosecond transient absorption technique to reveal the excited-state dynamics of salinixanthin
Popular Abstract in Swedish Evangelium Cyrillicum Gothoburgense, ECG, ett tetraevangelium som förvaras i Göteborgs universitets-bibliotek, har studerats i flera avseenden. Den kodikologiska studien visar att handskriften har restaurerats tidigare och att några sidor fattas i början och i slutet. Vattenmärket är ett vildsvin, vilket daterar ECG till 1605-1625 med stöd av ett identiskt vattenmärke i
Chromosomal region 13q21-q22 harbors a putative breast cancer susceptibility gene and has been implicated as a common site for somatic deletions in a variety of malignant tumors. We have built a complete physical clone contig for a region between D13S1308 and AFM220YE9 based on 18 yeast artificial chromosome and 81 bacterial artificial chromosome (BAC) clones linked together by 22 genetic markers
Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)
The catalytic properties of the rotenone-sensitive NADH:ubiquinone reductase (Complex I) in bovine heart submitochondrial particles and in inside-out vesicles derived from Paracoccus denitrificans and Rhodobacter capsulatus were compared. The prokaryotic enzymes catalyze the NADH oxidase and NADH:quinone reductase reactions with similar kinetic parameters as those for the mammalian Complex I, exce
Water–biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of water in intact cells, radically different views about the properties of cell wa
Cytokines play an important role in the regulation of homeostasis and inflammation. A de-regulated cytokine function can subsequently promote chronic inflammation. This is supported by clinical evidence showing the beneficial effect of inhibiting TNF-alpha through injection of antibodies and soluble receptor in disorders such as rheumatoid arthritis and Crohn's disease. Systemic anti-TNF-alpha the
A synthetic fluorapatite was prepared that undergoes a phase transformation generated during a dialysis step. A surface layer with the composition Ca(9)(HPO(4))(2)(PO(4))(4)F(2) is formed, which is suggested to form as one calcium atom is replaced by two protons. A surface complexation model, based upon XPS measurements, potentiometric titration data, batch experiments, and zeta-potential measurem
The dynamic soil model SAFE was calibrated and validated in a small hardwood forest of southern Quebec as a function of its ability to reproduce current soil chemistry and similar pre-industrial soil conditions despite the difference in forest history. SAFE was relatively accurate for reproducing soil chemistry, but comparison of pre-industrial soil conditions between unburned and burned stands ca
The essential protein Cdc13p binds the single-stranded telomeric 3' overhangs in Saccharomyces cerevisiae and takes part in the regulation of telomere length. The DNA-binding domain (DBD) of Cdc13p is structurally established by an oligonucleotide/oligosaccharide-binding (OB)-fold domain. The sequence homolog in Saccharomyces castellii (scasCDC13) was characterized previously, and the full-length
Popular Abstract in Swedish Barksprickor på bok och gran i södra Sverige. Jag har undersökt samband mellan barksprickor, frostkänslighet och näringsstatus hos bok och gran i södra Sverige, samt om åtgärder mot markförsurning och näringsobalans i form av kalkning och vitaliseringsgödsling kan minska trädens frostkänslighet och därmed minska uppkomsten av barksprickor. Frost kan skada den inre, leStrong temperature fluctuations and pathogen attacks can cause bark lesions, visible signs of wounds in the phloem and cambium. Pathogenic insects and fungi are able to invade lesions that have not healed, further increasing the damage. The ability of the tree to withstand climatic and biotic stress can be lowered by air pollution, especially N deposition, with subsequent alterations in the soil c
The main objective of this ethnological thesis is to investigate the linkage between everyday life with a genetic disease and intrinsic patterns of modernity. The thesis is a compilation thesis that contains four individual articles each addressing the everyday experience of a genetic disease from different angles, with different research questions and theoretical presumptions. Each of the four ar
Popular Abstract in Swedish Bildning, bearbetning och upplagring av cathepsin G, proteinas 3 och azurocidin - närbesläktade bakteriedödande proteiner i vita blodkroppar Människans kropp utsätts dagligen för fientliga attacker av olika sorters mikroorganismer, tillhörande bakterie-, virus- eller svampsläktet. Så länge vi är friska och vårt immunförsvar fungerar, kan vi som tur är framgångsrikt föThe neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. We devel
Popular Abstract in Swedish De halländska städerna har ibland setts som föga mer än förvuxna bondbyar eller ”agrara köpstäder”. Men hur förhöll det sig med den saken egentligen? Var tillvaron i städerna främst präglad av närheten till det agrara omlandet eller har kontakterna med de större köpstäderna spelat en större roll? Hur har städer och byar förhållit sig till varandra under olika tidsperiodDuring the 1700's lifestyle and material culture varied a lot between towns and rural areas. The aim for this thesis is to study how this difference between town and countryside emerges and how an identity as a burgher or farmer will manifest itself in the material culture. An important question is if it is possible to find a particular urban lifestyle and if that is the case, what it looks like.
Studying family, migration, and welfare from multidisciplinary perspectives This research environment offers a platform for sharing and deliberating sociological and anthropological analyses pertaining to family- and gender relations, migration and social welfare. Our studies address topics such as the vulnerable position and experiences of migrants across different regions, evolving dynamics of c
https://www.soc.lu.se/en/research-environments-and-groups/family-migration-and-welfare-famiw - 2026-07-13
Lunds universitet deltar i ULF - Utbildning, Lärande, Forskning som syftar till att utveckla hållbara samverkansmodeller mellan akademi och skola. Målet med ULF är att ta fram en infrastruktur med långsiktigt hållbara samverkansmodeller mellan akademi och skolhuvudmän för att stärka den vetenskapliga grunden och det vetenskapliga förhållningssättet i skolan. När teori och praktik vävs tätare ihop
https://www.mhm.lu.se/samverkan/praktiknara-skolforskning - 2026-07-13
