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BACKGROUND AND PURPOSE: A new concept to increase return to work for patients listed as sick with chronic musculoskeletal pain has been used at a rehabilitation centre in Luleå, Sweden. The programme includes work for three days a week and intensive rehabilitation for two days a week, for 12 weeks, as a combination of 'on the job' training and rehabilitation after a period off work sick. The rehab
Populärvetenskaplig sammanfattning Genetisk variation och genuttryck i Langerhanska öar Projekt 1 - Genetisk variation DNA är den mänskliga cellens informationslagringsenhet och består av långa sekvenser av de fyra nukleotiderna adenin(A), tymin(T), cytosin(C) och guanin(G). Proteiner kan binda till DNA och översätta delar av dessa sekvenser(gener) till RNA, en liknande typ av molekyl. RNA kanAbstract This article describes the creation of a pipeline for variant calling from high-throughput next-generation exome and RNA sequencing data using commonly used bioinformatics tools. High-throughput sequencing data from six pancreatic islet cell samples were analyzed using the pipeline, and the resulting variant calls were validated against chip genotyping data from the same individuals. The
Popular science summary: Non-invasive genetic monitoring of large carnivores Proper conservation planning of endangered wildlife populations is closely tied to availability of scientifically-sound abundance and distribution data. However, inquiring high quality data for rare or elusive carnivore species inhabiting remote habitats is extremely challenging. Non-invasive collection of DNA sources (
Denna kandidatuppsats utreder frågan om straffet livstids fängelse i Sverige bör kvarstå i sin nuvarande utformning. I uppsatsen görs en beskrivning av den historiska bakgrunden till straffet. Uppsatsens syfte är att klargöra om livstidsstraffet är en försvarlig påföljd i vårt moderna rätts-samhälle. Uppsatsen baseras på ett rättsutvecklingsperspektiv för att förklara hur livstidsstraffet fått siThis bachelor’s thesis investigates the question if the sentence of life imprisonment in Sweden ought to be maintained in its present form. The thesis makes a historical description of the sen-tence since its purpose is to clarify whether the life sentence is an appropriate penalty in todays modern society founded on the rule of law. In order to explain how the life sentence has come into use and
PFAS (per- and polyfluoroalkyl substances) is a large group of pollutants that, over the last decade have been of great academic concern since it has been found all around the globe. PFAS is ubiquitous in our environment and frequently found in low background concentrations in soil and water; recent research has also found that PFAS occur in biotic samples, such as fish and plants. This literature
Iron is an important material in the study of societies of the Iron Age and later periods. Not only does it give its name to the period it was also an integrated part in every humans’ life from the Iron Age and forward. And yet this material is many times just assumed to be there without much consideration of how it got there. In this master thesis, the author thus tries to bridge this gap in betw
Osteosarcoma is a malignant cancer of the bone mainly affecting adolescents. Despite progress, the clinical management of osteosarcoma is still challenging. With the current chemotherapy protocol being used for more than 30 years, the number of poor responders is increasing. Although new treatments have been explored since then, no improved tumor eradication effect have been found. In the present
We present genome assemblies from two male Aricia agestis specimens (the Brown Argus; Arthropoda; Insecta; Lepidoptera; Lycaenidae). The genome sequences are 435.3 and 437.4 megabases in span. Each assembly is scaffolded into 23 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genomes were assembled and are 15.47 and 15.45 kilobases in length. Gene annotation of these
Abstract in GermanDas Boot gilt als ein herausragendesSymbol der nordischen Bronzezeit, dargestellt in Tausendenvon Felsbildern und auf vielen Metallgegenständen in ganzSkandinavien. Paradoxerweise sind direkte Hinweise aufdiese Boote rar, und die Orte, an denen Boote gebaut wurden,bleiben größtenteils schwer fassbar. In diesem Artikel schla-gen wir vor, dass die sogenannten Kochgruben entlang derThe boat stands out as a prominent symbol of the Nordic Bronze Age, depicted at thousands of rock art sites and on several metal objects throughout Scandinavia. Paradoxically, direct evidence of these boats is scarce, and the locations where boats were constructed remain largely elusive. In this paper, we put forth the proposition that many ostensibly mislabelled cooking pits along the coast might
Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c
Purpose: In this study, we have quantified the setup deviation and time gain when using fast surface scanning for daily setup/positioning with weekly megavoltage computed tomography (MVCT) and compared it to daily MVCT. Methods: A total of 16 835 treatment fractions were analyzed, treated, and positioned using our TomoTherapy HD (Accuray Inc., Madison, USA) installed with a Sentinel optical surfac
Europaparlamentets och rådets direktiv 2012/13/EU om rätten till information vid straffrättsliga förfaranden utgör en del i en färdplan inom EU att förstärka rättighetsskyddet för misstänkta personer i brottmålsförfaranden. Artikel 7.1 i direktivet införlivades med svensk rätt den 1 juni 2014 genom införandet av 24 kap. 9 a § rättegångsbalken. Enligt artikel 7.1 i direktivet ska den som frihetsberDirective 2012/13/EU on the right to information in criminal proceedings (the Directive) is part of a road map within EU to strengthen the protection of rights of suspects in criminal proceedings. Article 7.1 of the Directive was implemented in Swedish procedural legislation on June 1st 2014 through a new statutory provision in the Swedish Code of Judicial Procedure, 24 kap. 9 a §. According to Ar
