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Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall
Many proteins rely on rare structural fluctuations for their function, whereby solvent and other small molecules gain transient access to internal cavities. In magnetic relaxation dispersion (MRD) experiments, water molecules buried in such cavities are used as intrinsic probes of the intermittent protein motions that govern their exchange with external solvent. While this has allowed a detailed c
BACKGROUND: Increased infection risk in inflammatory rheumatic diseases may be due to inflammation or immunosuppressive treatment. The influence of tumor necrosis factor (TNF) inhibitors on the risk of developing surgical site infections (SSIs) is not fully known. We compared the incidence of SSI after elective orthopedic surgery or hand surgery in patients with a rheumatic disease when TNF inhibi
Recent Hubble Space Telescope observations of a large sample of globular clusters reveal that every cluster contains between 40 and 400 blue stragglers.The population does not correlate with either stellar collision rate (as would be expected if all blue stragglers were formed via collisions) or total mass (as would be expected if all blue stragglers were formed via the unhindered evolution of a s
Streptococcus pyogenes, the most significant streptococcal species in clinical medicine, expresses surface proteins with affinity for several human plasma proteins. Here we report that kininogens, the precursors to the vasoactive kinins, bind to the surface of S. pyogenes. M protein, a surface molecule and a major virulence factor-in these bacteria, occurs in > 80 different serotypes. Among 49 str
Urbaniseringen i världen har de senaste 60 åren accelererat, och folk bor numera allt tätare och spenderar större delen av livet inomhus. Samtidigt pågår en trend av ökad psykisk ohälsa i många länder, där urbaniseringen kan vara en påverkande faktor. Studier visar att närhet till natur gör oss mer välmående. Ett sätt att uppnå detta inomhus är att ha inomhusväxter. Dock är ett problem med att ha Urbanization in the world has during the past 60 years accelerated, resulting in people living in more densely populated areas and spending a majority of their lives indoors. Another ongoing trend in many countries is an increase in mental health issues, where urbanization could be a contributing factor. Studies have shown that closeness to nature increases our well-being. One way to achieve this
III-V semiconductors are a profound part of the optoelectronics industry and new developments in alloy compositions and architectures are constantly emerging. Lowdimensional semiconductors, such as nanowires (NWs) have shown to have improved characteristics in certain areas such as enhanced light absorption and can furthermore be integrated on Silicon (Si) plattforms and are thus predicted to be a
Dark matter is the greatest mystery of modern particle physics and cosmology. Although an overwhelming amount of observational cosmological evidence has pointed towards a dark sector, only its gravitational effect has been experimentally confirmed. Currently, no other properties of dark matter are known, including its mass, interactions else than gravitational and potential mediators between dark
Popular Abstract in Swedish Ämnet för föreliggande avhandling är utveckling av förbränningsmodell för modellering av turbulent icke förblandad förbränning i motorrelaterade tillämpningar. I cylindern i en dieselmotor sker förbränningen under påverkan av och i interaktion med det turbulenta flödesfältet. Det finns härvidlag ett flertal svårigheter för att uppnå acceptabel noggrannhet och acceptablaThree different methods for Reynolds-averaged Navier-Stokes computational fluid dynamics modeling of non-premixed ignition and combustion using tabulated chemistry have been developed. All methods make use of flamelet libraries, where the flamelet auto-ignition process is parameterized using a progress variable. The progress variable parameterization of the auto-ignition chemistry allows for using
Japanese knotweed (Reynoutria japonica) is a problematic plant species that causes a lot of damage on anthropological constructions as well as ecosystems throughout Europe. Several attempts have been made to control this species, such as glyphosates, cutting/mowing, covering with geoweave and digging, so far with varying degrees of success. In recent times different techniques of heat treatment ha
This thesis was done in collaboration with the department of Food Technology at LTH, Aventure AB, and Arwa Foodtech AB. The aim of the project was to develop the base for a baobab based, spoonable protein snack, comparable to quarg but free from ingredients of animal origin. At the time of writing, one of the biggest if not the biggest trend in the food industry is the replacement of animal-source
In this thesis an adaptive optics system has been developed, implemented and evaluated at the Lund High Power Laser facility, Atomic Physics Division, Lund Institute of Technology. The laser system delivers ultrashort pulses with peak powers exceeding 40 TW at a repetition rate of 10 Hz. The pulses are focused to achieve extreme irradiance exceeding 1019 W/cm2 . In order to increase the peak inten
Procedures for sample clean-up and concentration in Capillary Zone Electrophoresis (CZE) have been developed for determination of drugs in biosample s. An on-capillary concentration technique based on enhanced field strengths, the double stacking procedure is introduced. This procedure allows for concentrationg all cations in the sample several hundred times essentially without loss of separation
This retrospective study sought to determine the safety and effectiveness of flecainide in children with normal hearts and those with congenital heart disease (CHD) or cardiomyopathy (CMO). Baseline and follow-up data at two pediatric cardiology sites were queried (2000–2015); a total of 175 patients (20 with CHD and two with CMO) receiving flecainide were assessed. When comparing patients with CH
The misfolding and aberrant aggregation of proteins into fibrillar structures is a key factor in some of the most prevalent human diseases, including diabetes and dementia. Low molecular weight oligomers are thought to be a central factor in the pathology of these diseases, as well as critical intermediates in the fibril formation process, and as such have received much recent attention. Moreover,
Objectives: The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system. Background: The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device. Methods: A multicenter, single-arm, retrospective registry was initiated to evaluate short-te
Mount Lovćen holds significant cultural, political and religious symbolism in Montenegro, especially due to the fact that the mountain is the last resting place of the prince-bishop and national poet Petar II Petrovich-Njegoš (1813–1851). In the twentieth century the grave of Njegoš has undergone profound material transformations. Each of these transformations has led to heated debates about the s
