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Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children
Aims To explore the prevalence and incidence of paediatric implantable cardioverter-defibrillator (ICD) patients in Sweden and identify risk factors associated with appropriate shocks and adverse events. Methods and results We performed a nationwide, retrospective cohort study of ICD use in paediatric patients (<19 years) between 1995 and 2017; 120 patients underwent ICD implantation at median age
BACKGROUND: GH therapy in adult patients with GH deficiency (GHD) was approved over 10 yr ago, and the indication has subsequently gained broad acceptance. The HypoCCS surveillance database is a suitable means to examine the evolution of diagnostic patterns since 1996.METHODS: Baseline demographics, reported cause of GHD, and diagnostic tests were available from 5893 GH-treated patients. Trends fo
Background: Measurements of local tissue water and circumferences are methods to evaluate lymphedema. Knowledge about reference values and reproducibility needs, however, to be determined for the head and neck (HN) area of healthy persons before it can be used in persons with HN lymphedema. The objective of this study was to evaluate the test-retest reliability including measurement errors of loca
Objectives Little is known about figure skaters’ mental health. This study aimed to describe anxiety and depression caseness (defined as a screening condition qualifying for psychiatric examination) in competitive figure skaters and analyse factors associated with such caseness.Methods A cross-sectional study was performed in April 2019 among all competitive figure skaters in the south-eastern reg
Purpose: Hematoma volume is the strongest predictor of patient outcome after intracerebral hemorrhage (ICH). The aim of this study was to validate novel fully automated software for quantification of ICH volume on non-contrast computed tomography (CT). Methods: The population was defined from the Swedish Stroke Register (RS) and included all patients with an ICH diagnosis during 2016–2019 in Regio
Within the next 30 years, two thirds of the human population will live in a city. This growing urban population requires a major shift in the way we produce and distribute food, since conventional agriculture practices are responsible for climate change, biodiversity losses, pollution of waterways, soil degradation, etc. Urban and peri-urban agriculture and forestry represent one of the strategies
BACKGROUND: Asthma is characterised by an aggravated immune response to respiratory viral infections. This phenomenon is a clinically well-recognised driver of acute exacerbations, but how different phenotypes of asthma respond immunologically to viruses is unclear. OBJECTIVES: To describe the association between different phenotypes and severity of asthma and bronchial epithelial immune responses
Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre
Modulbaserad lakvattenbehandling - en möjlighet att minska soptipparnas påverkan på människa och miljö? Uppemot 8000 gamla övergivna deponier och ett 70-tal aktiva deponier finns i Sverige. Gemensamt för dessa är att de kan ge upphov till ett förorenat lakvatten. Genom tillämpningen av ett modulbaserat reningssystem kan effekterna på människa och miljö begränsas. Modulsystemet har visat sig vara fA change in legislation has resulted in that many of Sweden’s municipal landfills were closed in the beginning of this century. After landfill completion, the oper-ator is responsible for at least 30 years to take action with regard to the protec-tion of human health and the Environment. In contribution Swedish landfill owners are facing increasing demands on local leachate treatment due to a chan
Synnerligen grov misshandel är en brottstyp som introducerades i svensk straffrätt år 2010, detta efter att regeringen uttryckt att straffskärpningar behövdes då man inte ansåg att de utdömda straffen var proportionerliga i förhållande till brottets allvar. Flertalet fall har sedermera hamnat i HD och hovrätterna och en praxis har skapats kring vad brottet innebär. Stort fokus läggs på hänsynslöshExceptional aggravated assault is a crime which was introduced to Swedish criminal law in 2010. The reason behind this was the fact that the Swedish government believed that harsher punishments were needed due to the fact that they were not proportional in comparison to the seriousness of the crime. Regarding what is to be considered as exceptional aggravated assault, the courts tend to focus on t
Solkräm – en miljöfara? Solskyddsprodukter används i allt större utsträckning för att skydda oss mot bland annat hudcancer. Vi informeras ständigt om vikten av att smörja oss med solskydd för att undvika skador på huden. Vad som däremot inte informeras om är att vi samtidigt bidrar till stora utsläpp av kemikalier som kan ge negativa effekter för livet i sjöar och hav. Solvårdsprodukter såldes The aim of the study was to perform a hazard assessment of ingredients in sunscreen products available on the Swedish market. Data was collected by documentation of all ingredients in 110 frequently occurring sunscreen products from 15 different brands and by a screening of four known databases for collection of hazard classifications of the ingredients. The study shows that 96 out of 347 ingredie
Virus är icke levande organismer som infekterar levande celler och förökar sig med hjälp av cellernas maskineri. De kan infektera alla typer av liv och de är totalt beroende av en värdcell. Alla virus innehåller genetiskt material samt en så kallad viruskapsid. Denna kapsid kan ha olika struktur och består av identiska proteinenheter. Kapsidens uppgift är att skydda det genetiska materialet. DettaAll viruses are composed of both genetic material and a capsid. The capsid is composed by identical protein subunits and the purpose is protection of the genetic material, in this case RNA. This project is about cowpea chlorotic mottle virus, also called CCMV, which is a plant virus and the disassembly and reassembly mechanisms of the capsid are investigated to understand how the capsid proteins a
This study aims to investigate the possibility of creating template times for rail works. Furthermore the study identifies a few effects which template times could have on planning of rail works, traffic and economy. Template times are being considered by the Swedish Transport Administration, Trafikverket, for the early stages of planning when there is a need to estimate the time required within t
Dangdut as the most popular music in Indonesia is highly sexualized on its representation of women despite the fact that Indonesia is a religious country. Dangdut’s sexualization is prominent on its performance, lyrics and culture. Banality, is the face of dangdut. During its public shows, many of the male audiences are more often than not intoxicated and engage in physical fights. Yet to date, th
The flesh-eating bacterium and inflammation run amok Streptococcus pyogenes is a bacterium that can infect humans and cause a wide range of symptoms, from the common strep throat to life-threatening infections. In rare cases, when this bacterium pushes its way down into our deeper skin layers, like in necrotizing skin and soft-tissue infection (NSTI), the destruction of the local tissue sometimes
Microalgae belong to the group of the oldest microorganisms that can grow in both fresh and marine water. Microalgal biomass is a rich source of vitamins, lipids, pigments and essential amino acids. Microalgal biomass can be used without cracking and fractionation or it can be cracked, fractionated and purified to get particular components like vitamins, pigments, omega-3 oils and proteins. But du
