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On the right track? Energy use, carbon emissions, and intensities of world rail transportation, 1840–2020

The history of rail transport can offer valuable insights for future energy transitions due to its importance in promoting clean mobility. There is a complex interplay between the evolution of the railway network, fuel consumption, efficiency, energy service, and CO2 emissions that requires further exploration. We developed a dataset that covers energy use in all stages of rail transportation, as

Gut response to pasteurized donor human milk in a porcine model of the premature infant

This study investigated the tolerance and safety of pasteurized donor human milk (PDHM) given either alone or together with commercially-used supplements in a porcine model of premature infants. A porcine model, mimicking human neonates at 30-32 weeks of gestational age, was used. The 7-day experiment was performed on 20 piglets. After birth, the piglets were infused with porcine immunoglobulins v

Assessment of Knowledge, Perception, Experience and Phobia toward Corticosteroids Use among the General Public in the Era of COVID-19 : A Multinational Study

Background: Corticosteroids play a significant role in managing the vast majority of inflammatory and immunologic conditions. To date, population-based studies on knowledge and attitudes concerning corticosteroids are scarce. This study aims to comprehensively assess knowledge, perception, experience and phobia toward corticosteroid use among the general population in the era of COVID-19. Methods:

Ergonomics in car disassembly industry on the edge of major rationalizations

A new EU directive on used vehicles has recently been introduced. It demands that for every scrapped car, at least 85% by weight must be recycled by the year 2006 and 95% by 2015. Today this level is about 80%. The growing car disassembly industry was chosen as the study object of this thesis. Due to the increased demands on recycling, the disassembly industry is expected to undergo comprehensive

Hemiarthroplasty for displaced femoral neck fracture: good clinical outcome but uneven distribution of occupational therapy.

Purpose. To assess rehabilitation, type of follow-up visits and outcome after bipolar hemiarthroplasty for femoral neck fracture. Method. Two hundred thirty-six consecutive patients with femoral neck fractures treated with hemiarthroplasty were followed for 30 months. Results. One hundred sixty-eight (71%) were women, 175 (74%) over 80 years old and 53 (22%) were demented. Of 150 patients with ava

Alterations in the rheological artery during rhythmic thigh flow profile in conduit femoral muscle contractions in humans

The present study examined the rheological blood velocity profile in the conduit femoral artery during rhythmic muscle contractions at different muscle forces. Eight healthy volunteers performed one-legged, dynamic knee-extensor exercise at work rates of 5, 10, 20, 30, and 40 W at 60 contractions per minute. The time and space-averaged, amplitude-weighted mean ( V-mean) and maximum (V-max) blood f

Amperometric sensors based on tyro sinase-modified screenprinted arrays

This paper describes the design, development and characteristics of a tyrosinase (polyphenol oxidase) modified amperometric screen-printed biosensor array, with the enzyme cross-linked in a redox-hydrogel namely the PVI13-dmeOs polymer. Two types of Au-screen-printed four-channel electrode arrays, differing in design and insulating layer, were compared and investigated. Au-, graphite-coated-Au- an

Optimizing rare disorder trials: a phase 1a/1b randomized study of KL1333 in adults with mitochondrial disease

Over the past two decades there has been increased interest in orphan drug development for rare diseases. However, hurdles to clinical trial design for these disorders remain. This phase 1a/1b study addressed several challenges, while evaluating the safety and tolerability of the novel oral molecule KL1333 in healthy volunteers and subjects with primary mitochondrial disease.KL1333 aims to normali

Birthweight and risk of chronic kidney disease after a type 2 diabetes diagnosis in the DD2 cohort

Aims/hypothesis: Low birthweight (LBW) is associated with younger age, less obesity and more hypertension among people recently diagnosed with type 2 diabetes, as well as increased cardiovascular morbidity and mortality risk. It is not known whether LBW is associated with an increased risk of incident chronic kidney disease (CKD) among people with a type 2 diabetes diagnosis. Methods: Original mid

Sertoli and Germ Cells Within Atrophic Seminiferous Tubules of Men With Non-Obstructive Azoospermia

Background: Infertile men with non-obstructive azoospermia (NOA) have impaired spermatogenesis. Dilated and un-dilated atrophic seminiferous tubules are often present in the testes of these patients, with the highest likelihood of active spermatogenesis in the dilated tubules. Little is known about the un-dilated tubules, which in NOA patients constitute the majority. To advance therapeutic strate

An experimental study of the flow around a circular cylinder: Influence of aspect ratio

The investigation is concentrated on two important quantities – the Strouhal number and the mean base suction coefficient, both measured at the mid-span position. Reynolds numbers from about 50 to 4 × 104 were investigated. Different aspect ratios, at low blockage ratios, were achieved by varying the distance between circular end plates (end plate diameter ratios between 10 and 30). It was not pos

Washing machine ownership and girls' school attendance : a cross-sectional analysis of adolescents in 19 middle-income countries

Excessive work among adolescents may compromise educational development. Without home appliances, household work can take over 50 h a week and an additional 30 h when an infant is present. School-aged girls are often tasked with doing laundry, which is time-consuming and inflexible without a washing machine. We determined the association between washing machine ownership and school attendance amon

Definition of landscape erosion units using a structural classification OASIS of Landsat TM satellite imageries, case study Lebanon.

Soil erosion by water is a major cause of landscape degradation in semi-humid to semi-arid Mediterranean environments. Terrain particularly susceptible to the phenomenon witness a combination of erosive soil, unconsolidated rock type, steep slope, high rainfall intensity, active tectonic movement, rapid land use change and intense human interference. Current erosion models (e.g. USLE, RUSLE) are b

Suppression of limbic motor seizures by electrical stimulation in thalamic reticular nucleus

Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsions and the establishment of a permanent epileptic syndrome. We studied here the effect of stimulations in the thalamic reticular nucleus (TRN) on. the development of seizures and hippocampal hyperexcitabi

Distribution of MR-detected cartilage defects of the patellofemoral joint in chronic knee pain

Objectives: The aim of the study was to detect cartilage defects and determine the center of these defects in MR imaging of the patellofemoral joint (PFJ) in middle-aged people with chronic knee pain. Design: In the format of a prospective study of early osteoarthritis (OA), this cross-sectional study of the signal knee (the most painful one at inclusion in the study in 1990) in 59 individuals, 30

Coronapandemins inverkan på chefers arbete med att främja sociala aktiviteter på äldreboenden. En kvalitativ studie baserad på intervju och enkäter med chefer på äldreboenden i Sverige

Bakgrund: Coronapandemin har medfört restriktioner där bland annat besöksförbud infördes från 30 mars till 1 oktober 2020 på äldreboenden i Sverige. Författarna undersöker hur besöksförbudet har påverkat hur chefer arbetar med socialt utanförskap och för att främja social inkludering under denna tidsperiod. Syfte: Syftet är att beskriva hur chefer på äldreboenden i Sverige har arbetat för att förhBackground: The corona pandemic in Sweden has led to a legislative restriction preventing visitation in nursing homes from March the 30th to October the 1st 2020. This means none was allowed to visit the elderly indoors to prevent outbreaks. Aim: The aim is to describe how managers in nursing homes in Sweden have worked to prevent social isolation for the elderly during the corona pandemic. Metho

Synthesis of Linear Fused Tröger’s Base Analogues

Tröger’s base molecule has a unique V-shaped cavity and a chiral structure. These molecules can be fused together in a linear fashion to create either tubular structure or zigzag structure. Different fields can be benefited from the applications of these molecules. Previous studies carried out in the Wärnmark group led to 30-step synthesis route to get a linearly fused heptakis-Tröger’s Base anal

Hydrogen intercalation of graphene grown on 6H-SiC(0001)

Atomic hydrogen exposures on a monolayer graphene grown on the SiC(0001) surface are shown to result in hydrogen intercalation. The hydrogen intercalation induces a transformation of the monolayer graphene and the carbon buffer layer to bi-layer graphene without a buffer layer. The STM, LEED, and core-level photoelectron spectroscopy measurements reveal that hydrogen atoms can go underneath the gr

Flow-injection assay of the pathogenic bacteria using lectin-based quartz crystal microbalance biosensor

A novel flow-injection assay of the pathogenic enterobacteria using novel lectin-based quartz crystal microbalance (QCM) biosensor has been proposed. The biosensing part of the analytical device contained the lectins - Concanavalin A, lectins from Ulex europeus, Maackia amurensis, Lens culinaris, wheat germ agglutinin - immobilized on the gold surface of quartz crystal electrode which served as a

Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

Background About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptor immunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggests that B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never been explored in a systematic manner or in a cohort of adequate size that wou