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The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced
Nationalparker utgör ett centralt element i naturvård runt hela jorden. Utöver naturvård så utgör tron på deras positiva effekt för regionalekonomisk utveckling en allt vanligare motivering för att grunda nya nationalparker. Forskningsläget kring omfattningen av sådana effekter är dock oklart och den ekonomiska effekten av nationalparker i Syd-, Väst, och Mellansverige har inte analyserats i någonNational parks are key parts of worldwide conservation initiatives. Increasingly, they are being founded not only to meet conservation goals but also because of their potential positive impact on regional economies. However, the results of previous research are ambiguous when it comes to assessing the magnitude of this effect and no such studies have been conducted for national parks in southern,
This study quantified major fluxes of carbon (C), heat and water, including uncertainty estimates, in a boreal forest in northern Sweden, using a process-based model (Coup-Model) and Bayesian calibration methodology. Coupled C, water and heat fluxes were described together with estimated uncertainties for all major components of the simulated C budget. Simulated mean gross primary production was 6
Popular Abstract in Swedish Akut bukspottkörtelinflammation, akut pankreatit (AP), är en sjukdom med varierande kliniska presentationer; från en mild och ödematös, till en svår och nekrotiserande form. Ungefär 75% av patienter med AP utvecklar en mild, självbegränsande sjukdom, men hos resten av patienterna progredierar sjukdomen till en svår form och dödligheten är så hög som 30% i denna grupp avAcute pancreatitis (AP) is an inflammatory disease with variable severity ranging from mild interstitial edematous to severe necrotizing disease. The overall mortality rate of AP is 8-9%. Specific treatment of AP is lacking which is partly related to an incomplete understanding of the basic pathophysiology behind the disease. It is widely held that premature intra-cellular trypsinogen activation a
Stripping gas is generally used to improve hydrogen yields in fermentations. Since CO2 is relatively easy to separate from hydrogen it could be an interesting stripping gas. However, a higher partial CO2 pressure is accompanied with an increased CO2 uptake in the liquid, where it hydrolyses and induces an increased requirement of NaOH to maintain the pH. This enhances the osmotic pressure in the c
Patients and methods: We conducted a study among 5533 survivors of testicular cancer on the basis of Swedish Family-Cancer Database for which the cancer data were retrieved from the nationwide Cancer Registry. Standardized incidence ratios (SIRs) of second cancer were calculated by comparing with the rates of the first cancers. The follow-up was started in 1980 and carried on through 2006. Results
Enzyme engineering for a better future It is essential for many organisms on this planet to be able to digest plants. One of those organisms is the blue mussel, which uses certain enzymes in its stomach to break down sugar fibers in the algae that it eats. But how does this really work, and can we use it for anything? Plant cells have very strong walls, protecting them from environmental stress.
The aim of this study was to achieve an understanding of how public media pictures mental illness with help from a stigma perspective. Throughout the investigation the Stigma Process by Link and Phelan (2001) has been used to understand and interpret the material acquired. In this study 36 articles from the largest Swedish evening papers have been analyzed and the articles have been taken within a
Background: Patients with hallux valgus deformity may require surgery but prospective patient-reported data is scarce. Methods: We evaluated 53 patients with a mean age of 55.3 years (SD 14.1, 50 women), who underwent surgery due to hallux valgus. They completed the PROMs SEFAS, EQ-5D and SF-36 before and 6, 12 and 24 months after surgery. Results: All patient-reported outcomes improved at 6, 12 a
OBJECTIVES: The aim of this study is to investigate associations between hospitalization for epilepsy and two factors: socioeconomic status and occupation.DESIGN AND SETTING: A nationwide database was constructed in Sweden by linking the Swedish Census to the Hospital Discharge Register to obtain data on all first-time hospitalizations for epilepsy in adults in Sweden during the study period (1987
Virtual reality headsets, such as the HTC Vive, can be used to model objects, forces, and interactions between objects with high perceived realism and accuracy. Moreover, they can accurately track movements of the head and the hands. This combination makes it possible to provide subjects with precise quantitative feedback on their performance while they are learning a motor task. Juggling is a cha
Popular Abstract in Swedish Ökad förståelse för hjärtats pumpfunktion är av stort intresse för att kunna förbättra diagnostik, behandling och prognoser för hjärtsjuka patienter. Blodflöde i hjärtat är direkt kopplat till hjärtats form och rörelse och kan därför vara en viktig markör för hjärtats funktion. Därför var målet med denna avhandling att utveckla och förbättra mätningar av blodflöde med hIncreased understanding of the pumping mechanics of the heart are of great importance to develop diagnostics, treatment and prognostics for cardiovascular diseases. Blood flow in the heart is connected to its anatomy and function, and may therefore be a sensitive marker of cardiac health and disease. Therefore, the aim of this thesis is to develop and validate methods for quantification and visual
We present Titta, an open-source toolbox for controlling eye trackers manufactured by Tobii AB from MATLAB and Python. The toolbox provides a wrapper around the Tobii Pro SDK, providing a convenient graphical participant setup, calibration and validation interface implemented using the PsychToolbox and PsychoPy toolboxes. The toolbox furthermore enables MATLAB and Python experiments to communicate
The research presented in this paper is based on interviews with 51 employees from 51 different organizations (including private and public sectors). Employees were interviewed more than once, over a period of 6 months, each interview lasted between 30 min to 1 h. The discussion in this paper is based on interviews during sessions which were explicitly dedicated to Information Systems and Cybersec
While numerous antibody-antigen systems have been structurally characterized, studies of structurally analogous T-cell receptor MHC systems have lagged behind largely due to the lack of a general TCR expression system. Efforts to develop bacterial systems have resulted in low yields (< 0.5 mg/l) of active material which is prone to proteolysis and aggregation. Here we report a strategy to secrete
A rat model was developed to assess bidirectional passage of macromolecules and low-molecular-weight markers across the intestinal barrier in intact and injured mucosa. Isolated in situ loops of distal small intestine were luminally perfused for 30 min with saline as control or HCl (pH 2.0) to induce an acute injury. The lumen-to-blood passage was followed during perfusion with bovine serum albumi
Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated the therapeutic potential of MCC950, a specific, small-molecule inhibitor of
