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Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation

Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated

The usefulness of direct ethanol metabolites in assessing alcohol intake in nonintoxicated male patients in an emergency room setting

Background: A major part of medical pathology in internal medicine is associated with chronic alcoholism. The aim of the current study was to investigate whether screening for Alcohol Use Disorders (AUD) can be improved through determination of direct ethanol metabolites compared to traditional biological state markers, the Alcohol Use Disorders Identification Test (AUDIT) and additional self-repo

Clinical characteristics and long-term outcomes following pancreatic injury – An international multicenter cohort study

Background: Trauma to the pancreas is rare but associated with significant morbidity. Currently available management guidelines are based on low-quality evidence and data on long-term outcomes is lacking. This study aimed to evaluate clinical characteristics and patient-reported long-term outcomes for pancreatic injury. Methods: A retrospective cohort study evaluating treatment for pancreatic inju

Allocating colorectal cancer patients to different risk categories by using a five-biomarker mRNA combination in lymph node analysis

Background and aims Curative surgery saves ≈50% of all patients with colorectal cancer (CRC) while remaining patients have synchronous or will develop metachronous metastases. Presently, the single most important prognostic factor is histopathological detection of disseminated tumor cells in regional lymph nodes. However, the routine method has several limitations. The aim was to identify biomarke

Preference-based valuation of treatment attributes in haemophilia A using web survey

Introduction: Clinical trials have shown promising results for extended half-life factor VIII concentrates but little is known about individuals' valuation of haemophilia treatment attributes. Aim: To assess patient/caregiver and population valuation of treatment attributes of prophylactic regimens for people with severe haemophilia A. Methods: Members ≥16 years of the Swedish Haemophilia Society

Accuracy and precision in super-resolution MRI : Enabling spherical tensor diffusion encoding at ultra-high b-values and high resolution

Diffusion MRI (dMRI) can probe the tissue microstructure but suffers from low signal-to-noise ratio (SNR) whenever high resolution is combined with high diffusion encoding strengths. Low SNR leads to poor precision as well as poor accuracy of the diffusion-weighted signal; the latter is caused by the rectified noise floor and can be observed as a positive bias in magnitude signal. Super-resolution

The gift of giving - En studie av koncernbidrag och lagen mot skatteflykt

Den svenska företagsbeskattningen baseras på att varje enskilt företag är ett självständigt skattskyldigt subjekt. Däremot finns vissa möjligheter att beakta flera företags resultat av näringsverksamhet när dessa ingår i en koncern. Ett alternativ som har ställts upp är de skatterättsliga koncernbidragen. Då koncernbidragsreglerna aktualiseras och en värdeöverföring har skett mellan två företag inSwedish corporate taxation is based on the fact that each individual company is an independently taxable subject. On the other hand, in some circumstances it is possible to take into account several companies' income of economic activities, when these are part of a corporate group. One option available is the group contribution. If the rules concerning group contributions are applicable and a

Barnets bästa i samband med umgängessabotage

Syftet med denna uppsats är att utreda umgängessabotage i relation till barnets bästa. Ämnet är aktuellt då antalet vårdnadstvister ökar. Dessutom finns det behov av att utreda frågan då barn i större utsträckning ses som individer med egna rättigheter och intressen. En sådan utveckling kan ses utifrån ändringen i FB år 2006 samt inkorporeringen av barnkonventionen. Enligt 6 kap. 2 a § FB ska baThe purpose of this thesis is to investigate visitation interference in relation to the child’s best interests. The topic is relevant as the number of custody disputes in Sweden has increased. In addition, there is a need to investigate the question because children are more widely regarded as individuals with their own rights and interests. Such development can be seen from the change in FB in 20

Welcome to Nowhere

We live in a world built on consumerist values and a spatial rationale of capital accumulation. This modern society has led to architecture thriving through super consumption and super production ultimately leading to the generic. Cities and spaces that were usually rich in variation and texture have now become an architectural melting pot. Architecture has become smooth, simplified and reduced to

Brandteknisk Riskvärdering av Dramaten - Kungliga Dramatiska Teatern i Stockholm

Denna rapport är skriven inom kursen ”VBRN70 - Brandteknisk riskvärdering” vid Lunds Tekniska Högskola. Rapporten omfattar en brand- och utrymningsanalys av Kungliga Dramatiska Teatern i Stockholm med fokus på personsäkerhet. Analysen inleddes med ett platsbesök för att få bättre kännedom om objektet. Utifrån observationer från platsbesöket och tillgänglig statistik identifierades därefter flertaThis report is a part of the course ”VBRN70 - Brandteknisk riskvärdering” given by Lund University of Technology. The report presents a fire and risk evaluation of the Royal Dramatical Theatre in Stockholm with focus on the safety of people in the building. The analysis started with a site visit to gain more knowledge of the object. From observations from the visit and available statistics on fi

OCEAN ACIDIFICATION

Ocean acidification is a consequence of the anthropogenic release of carbon dioxide (CO2) to the atmosphere. When CO2 is dissolved in water it affects the composition of ions and lowers the pH of the water. As the partial CO2 pressure in the atmosphere increases a new balance is reached with the surface waters which causes the pH of the surface oceans to decrease. For small shallow seas this effec

Analysis and Measurements of Vehicle Door Structural Dynamic Response

In order to reduce lead time and cost in the product development of vehicles more development will be made virtually. However, the predictability capability of simulation models is questioned and the simulation models need to be correlated versus hardware measurements and modeling techniques improved. As part of the process of vehicle system model capability improvements the main objective of thi

Utvärdering utav benfintliga metoder för synlig digital vattenmärkning av statiska bilder

Digital watermarking is done by adding a piece of data to a signal, which depending on the target media type, may be a picture, audio or video signal. The purpose of this additional signal is to provide a consistent signature linked to the original source which then remains through the act of copying. This allows the author to obstruct the act of theft by adding this signal to his or her creation.

Algorithms for the multimodal acoustophoresis control of particle trajectories

Styrning av partiklar med ljud och intelligenta algoritmer Det här examensarbetet handlar om att styra små partiklar i vätska utan att röra vid dem, med hjälp av ljud. Genom en teknik som kallas multimodal akustofores kombineras flera olika ljudvågor för att noggrant kunna påverka partiklarnas rörelser. Metoden är särskilt intressant inom biomedicin, till exempel vid analys av enskilda celler ellThis thesis explores a range of control algorithms for multimodal acoustophoresis, the process of manipulating particles in a fluid by simultaneously using several acoustic modes. The aim of the algorithms is to precisely guide particle trajectories in acoustofluidic systems, motivated by the demand for non-invasive, scalable manipulation techniques in biomedical applications such as single-cell a

Vad kommuniceras med biblioteksplanen? En dokumentstudie kring biblioteksplanens utformning i relation till det kommunala självstyret

This master’s thesis is a qualitative content analysis of nine municipal library plans (and two county library plans) with a basis in new institutionalism, specifically in regards to legitimacy, homogeneity as well as themes and patterns in the sourcematerial. With a basis in the history of the library plan and the municipal gouvernance, debate in regards to cultural policy, the downsizing of libr

Functional Characterization of an Oat Lipase Candidate

Oats (Avena sativa) are a valued food product due to their nutritional profile and proven health benefits. However, prior to consumption, they require heat processing to prevent off-flavors and undesirable mouthfeel caused by lipase-catalyzed hydrolysis of lipids. While the heat treatment inactivates lipases, it raises concerns regarding sustainability and oat quality. The discovery of novel funct

Design and Analysis of Antenna Selection in Massive MIMO

Mobile communications have evolved with the commercial deployment of 5G and initial studies of 6G. New solutions and innovative technologies are being incorporated to reach the target requirements. One of the key technologies in mobile networks is massive multiple-input-multiple-output (MIMO). Increasing the number of antennas offers significant benefits in coverage, reliability, and spectral effi

Framtidens hållbara drivmedel: Klimatsmarta omställningar för yrkesfordon i jordbrukssektorn

I takt med att hållbarhet blir viktigare söker många företag inom jordbrukssektorn lösningar för att fasa ut fossila drivmedel. Utmaningen blir ännu mer komplex när ersättningen ska vara kompatibel med en existerande fordonsflotta, utan investering i nya fordon. Denna studie jämförde fyra kommersiellt tillgängliga och förnybara drivmedel med referensbränslet diesel. De undersökta drivmedlen är HVAs sustainability becomes more important in today's society, many companies in the agricultural sector are looking for new alternatives to fossil fuels. The challenge becomes even more complex when the replacement must be compatible with an existing vehicle fleet, without requiring new investments in vehicles. This report compares four commercially available and renewable fuels, using convent

Clinical Significance of Time-to-Surgery and COVID-19 Pandemic in Surgically Treated Non-Small Cell Lung Cancer

Objectives: Timely discovery and adequate patient management are crucial in non-small cell lung cancer (NSCLC) since long-term survival is only achievable in early-stage disease. In our study, we aimed to elucidate the effects of time to surgery on survival and to assess the impact of the COVID-19 pandemic on elapsed time until surgery. Methods: In total, 2536 Caucasian NSCLC patients who underwen

Laglottens aktualitet - Från blodsband till sociala familjekonstellationer

Den svenska successionsrätten innefattar en rätt för bröstarvingar att erhålla en laglott. Bestämmelserna har blivit anklagade för att vara föråldrade och har varit omdebatterad såväl i media som i riksdagen. Följande uppsats kommer att undersöka om laglotten har blivit föråldrad och utröna vilka argument som kan tänkas motivera ett bibehållande av lagstiftningen. Syftet är att se hur gällande rätThe Swedish law of succession includes a right for the direct heir to retain a part of the heritage if the deceased have drawn a will. This phenomenon is called statutory share of inheritance (in Swedish: laglott). The regulations have been accused of being out-of-date and have been up for debate in both media as well as in the parliament. Following essay will examine if the statutory share is out