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Tuning of protein surface charge is a fundamental mechanism in biological systems. Protein charge is regulated in a physiological context by pH and interaction with counterions. We report on charge inversion and the related reentrant condensation in solutions of globular proteins with different multivalent metal cations. In particular, we focus on the changes in phase behavior and charge regulatio
A 650-yr-long sediment sequence from a crater lake on Tristan da Cunha, South Atlantic, was analysed for its Be-10 content. Based on C-14 dating, and sedimentary, geochemical, magnetic and palynological records, the period between 900 and 1450 AD appears to have been unusually stable in terms of sedimentation and vegetation and therefore this period was chosen for analysis of the Be-10 content. Du
When selection on males and females differs, the sexes may diverge in phenotype. Hormones serve as a proximate regulator of sex differences by mediating sex-biased trait expression. To integrate these perspectives, we consider how suites of traits mediated by the same hormone in both sexes might respond to selection. In male birds, plasma testosterone (T) varies seasonally and among species accord
Human innate lymphoid cells have been described to exist in different organs, with functional deregulation of these cells contributing to several disease states. Here, we performed the first detailed characterization of the phenotype, tissue-residency properties, and functionality of ILC1s, ILC2s, and ILC3s in the human adult and fetal liver. In addition, we investigated changes in the ILC compart
In strategic management, the concept of organizational capabilities appears in two sets of related literatures: the resource-based view and the dynamic capabilities approach. The resource-based view treats organizational capabilities as unitary factors that explain cross-sectional industry performance differentials. The dynamic capabilities approach, on the other hand, treats organizational capabi
The development of soft anisotropic building blocks is of great interest for various applications in soft matter. Furthermore, such systems would be important model systems for ordering phenomena in fundamental soft matter science. In this work, we address the challenge of creating hollow and anisotropically shaped thermoresponsive microgels, polymeric networks with a solvent filled cavity in thei
Local governments have come to play an increasingly active role in addressing current environmental challenges. In addition to improving the environmental performance of a specific city, such initiatives can potentially spur policy change at other levels of government and thereby contribute to the addressing of global environmental challenges. This type of interplay between local and higher levels
Natural resources can have a powerful impact on the public budget but may also hinder the development of other sources of revenue, thus limiting the long-term development of fiscal capacity in resource-rich countries. This article evaluates both possible effects bycomparing the long-term evolution (1850s-1930s) of public revenues in Andean (Bolivia,Chile and Peru) and Nordic (Norway and Sweden) co
Purpose: To investigate how consumers understand free services on the Internet. Theories: The research is primarily based upon theories of gift giving. Methodology and analysis: The Internet is not a tangible marketplace and in order to understand the value of the free services online, we used consumers' behavioral accounts to explain how they perceive the free services that are common online.
Which sources most influence the language spoken in Israel? Is it the same language as the Hebrew of its ancestral heritage? Which periods in history brought about the changes of contemporary lexicon? These are the questions addressed in the current essay, which presents the inspection of nouns appearing in a recent newspaper, and their categorization according to the different periods in the his
The estimation of regression parameters in spatially referenced data plays a crucial role across various scientific domains. A common approach involves employing an additive regression model to capture the relationship between observations and covariates, accounting for spatial variability not explained by the covariates through a Gaussian random field. We study the effect of misspecified covariat
This paper surveys the literature on historical national accounting, discusses the importance of relative income benchmarks for, in particular, historical income estimates, and presents an update of long run global economic development with a new version of the Maddison Project Database (MPD). As benchmarks are central to methodologies for global income comparisons over time, and therefore vital t
An increasingly competitive market, as well as transforming consumer expectations, have considerably altered the socio-economic landscape in which contemporary profit-making organizations operate. As a result, it is more difficult than ever to establish a successful and distinct brand, whilst adhering to fast-changing customer demands – especially when consumers bank on brands to fulfil a higher p
The United Nation’s Sustainable Development Goals state that education is both an end and a means for achieving sustainable development. Currently, education for sustainability focuses on (assessing and addressing) the external world of ecosystems, wider socio-economic structures, technology, and governance dynamics. A major shortcoming of such approaches is the neglect of inner dimensions and cap
Observations of binaries containing pairs of neutron stars using the upcoming space-based gravitational wave observatory, LISA, have the potential to improve our understanding of neutron star physics and binary evolution. In this work, we assess the effect of changing the model of the Milky Way’s kinematics and star formation history on predictions of the population of double neutron stars that wi
In a future warmer climate, extremely dry, warm summers might become more common. Soil weathering is affected by temperature and precipitation, and climate change and droughts can therefore affect soil chemistry and plant nutrition. In this study, climate change and drought effects on soil weathering rates and release of Ca, Mg, K and Na were studied on seven forest sites across different climates
Journal of GLBT Family StudiesAlthough Vietnamese society is currently undergoing significant changes with regards to the rights and perceptions of gay, lesbian, bisexual, transgender, and queer (GLBTQ) people, dominant socio-cultural norms related to gender, sexuality, and the importance of the patrilineal family regime continue to cast a shadow over the lives of GLBTQ in contemporary Vietnam. Based on ethnographic fieldwork
The aim of this treatise is to sketch out a strategy how to find a cause and cure for cognitive brain disorders and then primarily Alzheimer’s disease (AD) based on recent and little explored research progress. Step one is to find the cause. Recent evolution has supplied the human brain with new astrocytes which regarding their remarkable properties can be expected to harbor the cause of AD and se
A numerical and experimental study on the devolatilization of a large biomass particle is carried out to quantify the effect of homogeneous volatile combustion on the conversion of the particle and on the temperature and species distribution at the particle vicinity. A global chemical kinetic mechanism and a detailed reaction mechanism are considered in a one dimensional numerical model that takes
