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Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step of the de novo pyrimidine biosynthesis pathway and uses ubiquinone Q10, a lipophilic molecule located in the inner mitochondrial membrane (IMM), as its co-substrate. DHODH is anchored to the IMM by a single transmembrane helix located at its N-terminus. Nevertheless, how DHODH function is determined by its surrounding membrane en
Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosystems and biodiversity, and mitigating their effects in the future. We present here the most spatially extensive and temporally continuous pollen-based r
Prostate-specific antigen (PSA) is a serine protease secreted by hath normal prostate glandular celts and prostate cancer cells. The major proteolytic substrates for PSA are the gel-forming proteins in semen, semenogelin (Sg) I and II. On the basis of the PSA cleavage map for Sg I and II, a series of small peptides (ie., ≤ 7 amino acids) was synthesized and coupled at the COOH terminus to 7-amino-
Nitrogenase is the only enzyme that can cleave the strong triple bond in N2, making nitrogen available for biological life. There are three isozymes of nitrogenase, differing in the composition of the active site, viz., Mo, V, and Fe-nitrogenase. Recently, the first crystal structure of Fe-nitrogenase was presented. We have performed the first combined quantum mechanical and molecular mechanical (
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. These infections have been classified as neglected diseases, and still require the development
The Paleocene-Eocene Thermal Maximum (PETM, ca. 56 Ma) is marked by a negative carbon isotope excursion (CIE) and increased global temperatures. The CIE is thought to result from the release of 13C-depleted carbon, although the source(s) of carbon and triggers for its release, its rate of release, and the mechanisms by which the Earth system recovered are all debated. Many of the proposed mechanis
Postal address P.O. Box 117, 221 00 Lund, SWEDEN Visiting address Sandgatan 13A, Lund Telephone +46 46 222 00 00 E-mail malin.schatz@sam.lu.se Website www.sam.lu.se/en Facul ty Board Instructions and procedures for programme evaluations by external experts at the Faculty of Social Sciences Introduction Lund University’s Policy for quality assurance and quality enhancement of education at Lund Univ
C4b-binding protein (C4BP) is best known as a potent soluble inhibitor of the classical and lectin pathways of the complement system. This large 500kDa multimeric plasma glycoprotein is expressed mainly in the liver but also in lung and pancreas. It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) d
Neural stem cells (NSCs) derived from human fetal striatum and transplanted as neurospheres survive in stroke-damaged striatum, migrate from the implantation site, and differentiate into mature neurons. Here, we investigated how various steps of neurogenesis are affected by intrastriatal transplantation of human NSCs at different time points after stroke and with different numbers of cells in each
Accurate and continuous monitoring of inland surface water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia
,. LUND UNIVERsrtY LUND UNIVERSITY MASTER'S PROGRAMME IN ENVIRONMENTAL SCIENCE WHEN'S DINNER READY? -An Evaluation of Community Gardening and its Contribution to A Sustainable Food System MASTER'S THE SIS Prepared by: Ulrika Bjurkell 3-505 Cranbrook rd., London, On P.O Box 28075 Canada E-mail: ulrikabjurkell@hotmail.com Supervised by: Carina Borgstrom-Hansson Departmentof HumanEcology Universityof
https://www.lumes.lu.se/sites/lumes.lu.se/files/bjurkell_ulrika.pdf - 2026-07-13
Guidelines and procedures for programme evaluations by external experts at the Faculty of Social Sciences Page 1 of 13 Faculty Board DECISION Reg. No. STYR 2024/2571 Date 2024-11-21 Guidelines and procedures for programme evaluations by external experts at the Faculty of Social Sciences This decision applies to evaluations initiated from 2025 onwards. Introduction The guidelines build upon the Qua
Vad forskar du om? – Sida 2 – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Kategori: Vad forskar du om? De slår ett slag för hjärtat 2019-03-26 Alla har känt hjärtat slå extra hårt och snabbt någon gång. Det kan vara under träning, när man ska prata inför publik eller
https://www.vetenskaphalsa.se/kategori/vad-forskar-du-om/page/2/ - 2026-07-12
astma – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Etikett: astma Samband mellan mycket hög PFAS-exponering och astma hos barn 2026-04-22 Forskare vid Lunds universitet har undersökt samband mellan exponering för PFAS och utveckling av astma. Resultaten visar att bla
https://www.vetenskaphalsa.se/tag/astma/ - 2026-07-12
JUNI 2012 Nyhetsbrev från stiftelsen Forska Lund - Insamlingsstiftelsen för forskning och utbildning inom Lunds universitet Tack för alla bidrag Ett stort tack för alla fantastiska bidrag som vi har fått in till forskningen vid Lunds universitet via stiftelsen Forska Lund. I skrivandets stund är det 80 000 kronor fördelat på 58 gåvor under 2012. Väldigt få kan på egen hand åstadkomma stora skillna
https://www.lu.se/sites/www.lu.se/files/nyhetsbrev_juni_2012.pdf - 2026-07-13
“Meet the nitrous oxide reducing microbes in soils and sediments” Mitigating N2O emissions - an ES delivered by soil microbes Sara Hallin Dept. Forest Mycology & Plant Pathology Swedish University of Agricultural Sciences, Uppsala ClimBEco Annual Meeting Aug 24-25, 2017 Höllviken « the microbial zoo » Biomass in soil: 10 ton/ha • Bacteria 1-2 ton Bacteria occupy <0.3% of pore space Fungi: 10 – 100
https://www.cec.lu.se/sites/cec.lu.se/files/sara_hallin.pdf - 2026-07-13
Popular Abstract in Undetermined 1971 förklarade president Richard Nixon, som så många amerikanska presidenter före honom, krig. Nixons fiende var dock något oortodox; Nixon förklarade krig mot cancer. I och med att senaten godkände ”National Cancer Act”, av pressen snabbt döpt till ”War on cancer”, hoppades Nixon att kunna utradera cancer med hjälp av kraftigt ökade anslag till cancerforskning koDespite recent advances in cancer treatment, truly innovative approaches are required to move beyond the modest benefits achieved to date. HAMLET is a human protein-lipid complex originally discovered in breast milk able to kill a wide range of tumour cells while leaving healthy, differentiated cells unaffected. The aim of this thesis was to identify mechanisms dictating HAMLET sensitivity and to
Popular Abstract in Swedish Proteiner I varje cell i kroppen finns en kopia av vårt DNA. DNA är uppdelat i en massa gener som vart och ett innehåller en karta för uppbyggnaden av ett protein. Dessa proteiner kontrollerar nästan alla aspekter av det vi kallar liv. De transporterar syre, bygger upp vävnad, extraherar energi ur den föda vi stoppar i oss och bygger upp alla molekyler som behövs för våThis thesis deals with Ca2+ binding to proteins, electrostatic interactions in and between proteins as well as inter- and intramolecular interactions. A computer program was developed to determine Ca2+ binding constants from experimental titration data of proteins. We further studied the effect of deamidation in the Ca2+ binding site of Calbindin D9k on the Ca2+ binding and cooperativity and concl
Popular Abstract in Swedish Nematod-fångande svampar är en grupp av filamentösa svampar som lever i jorden. De kan som deras namn antyder fånga och infektera nematoder. Varför är det då viktigt att studera dessa svampar? Svaret är just nematoder. Nematoder, även kända som rundmaskar, kan infektera både människor, djur och växter. Vi i Europa är relativt förskonade mot dessa infektioner om man jämfNematode-trapping fungi are soil-living organisms with the unique ability to capture and infect free-living nematodes. The interest in studying these fungi arises from their potential use as biological control agents for plant- and animal-parasitic nematodes. To enter the parasitic stage, nematode-trapping fungi develop different kinds of trapping structures. In order to understand more about the
Popular Abstract in Swedish Skulle p53-målgenen TRIM22 kunna skydda mot cancer uppkomst? Frisk blodbildning En frisk vuxen människa har mellan fyra och sex liter blod, beroende på individens kroppsstorlek. Blodet produceras i benmärgen som finns i skelettbenen. Varje sekund bildas normalt i benmärgen tre till fyra miljoner blodkroppar från våra stamceller. Blodkropparna är specialiserade celler The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using a cDNA microarray analysis, I identified TRIM22/Staf50 as a novel direct target gene to p53. The fun
