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Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de
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Pyranose 2-oxidase (P20x) has several proposed biotechnological applications such as a bio-component in biofuel cells or for carbohydrate transformations. To improve some of the catalytic properties of P20x from Trametes multicolor, we selected a semi-rational approach of enzyme engineering, saturation mutagenesis of active-site residues and subsequent screening of mutant libraries for improved ac
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Abstract in French:Au cours des dernières décennies, les études alévies se sont affirmées comme un champ interdisciplinaire, à la croisée de l’histoire, de l’anthropologie, de la sociologie, des sciences politiques et des sciences des religions. Si cette consolidation institutionnelle et académique représente une avancée majeure, certains aspects clés de l’histoire alévie restent sujets à débat, eOver recent decades, Alevi Studies has emerged as an interdisciplinary field drawing on history, anthropology, sociology, political science, and religious studies. While this institutional and scholarly consolidation marks significant progress, key aspects of Alevi history remain contested, particularly interpretations shaped by early 20th-century nation-building paradigms. Dominant binaries such