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When investigating a settlement dated to the late Mesolithic,c.5500 cal BC, at Strandvägen in south-central Sweden, an extensive assemblageof implements made of bone and antler was found. Among these finds was a richlydecorated antler piece, likely part of an antler axe. Originally it was equippedwith shallow ornamentation that was later removed and replaced by a seconddeeper motif of longitudinal

Robins captured as passage migrants by the Baltic Sea in Sweden at Falsterbo and Ottenby Bird Observatories, respectively, differ with respect to body mass, fat load and orientation behaviour. Relatively more birds with large visual fat deposits are captured at Ottenby than at Falsterbo, but robins at Falsterbo carry more fat than robins at Ottenby. Robins with small fat loads at Ottenby probably

Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p

Objectives: Fusobacterium can contribute to oral diseases, but also pose as a systemic risk factor. This genus, and especially F. nucleatum, can be found in colorectal cancer (CRC) tissue and is involved in multiple aspects of this type of cancer. Previous studies indicated a possible oral origin of these bacteria; however, stronger evidence is needed to reach a definitive conclusion. This pilot s

Traditionally, traffic safety is expressed through the number of accidents (crashes) or people injured, since these are the most direct manifestations of an unsafe traffic environment. As we discuss in this chapter, such an approach has its limitations due to the low frequency of accidents and some other issues. Neither is it unusual that accident data is not available, not reliable or lacks impor

The cytokine IL-23 plays important roles in intestinal barrier protection and integrity, but is also linked to chronic inflammation. In this issue of JEM, Ohara et al. (https://doi.org/10.1084/jem.20230923) provide clarity on the much-debated question of which cells produce IL-23.

Objectives To determine whether videos taken by parents of their infants' spontaneous movements were in accordance with required standards in the In-Motion-App, and whether the videos could be remotely scored by a trained General Movement Assessment (GMA) observer. Additionally, to assess the feasibility of using home-based video recordings for automated tracking of spontaneous movements, and to e

As an alternative to clear-cutting, variable-retention harvesting is now standard forest management practice on the coast of British Columbia and in temperate forests globally, due to the benefits associated with maintaining mature forest species and forest structural diversity. Although there is some evidence that variable-retention harvesting, particularly single-tree (dispersed) retention will

The transient electromagnetic (TEM) method is widely used in resistivity mapping but rarely applied in monitoring experiments. In this study, we present an algorithm to invert time-lapse TEM data, with inversion of both synthetic data and field data. Three main novelties distinguish this new inversion algorithm: i) a multiple-mesh approach is used for the definition of model parameters and forward

Protein scaffolds direct the organization of amorphous precursors that transform into mineralized tissues, but the templating mechanism remains elusive. Motivated by models for the biomineralization of tooth enamel, wherein amyloid-like amelogenin nanoribbons guide the mineralization of apatite filaments, we investigated the impact of nanoribbon structure, sequence, and chemistry on amorphous calc

Affibody molecules, small (7 kDa) scaffold proteins, are a promising class of probes for radionuclide molecular imaging. Radiolabeling of Affibody molecules with the positron-emitting nuclide 68Ga would permit the use of positron emission tomography (PET), providing better resolution, sensitivity, and quantification accuracy than single-photon emission computed tomography (SPECT). The synthetic an

Monosubstituted naphthoxylosides have been shown to function as substrates for, and inhibitors of, the enzyme β4GalT7, a key enzyme in the biosynthetic pathway leading to glycosaminoglycans and proteoglycans. In this article, we explore the synthesis of 16 xyloside analogues, modified at two different positions, as well as their function as inhibitors of and/or substrates for the enzyme. Seemingly