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A Zn(Cys)4 center has been found in the C-terminal region of the crystal structure of the anaerobic class III ribonucleotide reductase (RNR) from bacteriophage T4. The metal center is structurally related to the zinc ribbon motif and to rubredoxin and rubrerythrin. Mutant enzymes of the homologous RNR from Escherichia coli, in which the coordinating cysteines, conserved in almost all known class I

Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V varia

Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (p

In this group we study how metastatic processes depend on suppression of the immune response and how the immune system actually instead promotes breast cancer metastasis. The research has a strong translational character with clinical collaborations and primary material as base in all projects. The focus is on immunosuppressive cell populations and metastatic processes in breast cancer. Understand

Popular Abstract in French La rencontre des sexes est une nécessité pour la majeure partie des organismes appartenant au règne animal. Au cours de l’évolution, différentes modalités sensorielles, comme la vue, l’ouie et l’odorat, sont apparues et ont été perfectionnées pour permettre aux organismes de percevoir l’environnement qui les entourent, et de communiquer. Reconnaître ses pairs de ses enneChemical communication by means of sex pheromones is central to the mating systems of a wide range of organisms. Because reproductive isolation is often based on pheromone differences, understanding how pheromones diverge is necessary for a complete comprehension of the speciation process. Moths (Insecta: Lepidoptera) contributes highly relevant examples to the theory of speciation because subtle

With "la Vie de Saint Louis", dated 1309, Jean de Joinville left to posterity a hybrid text that defies definitive classification. His “I” is the very first in French literature and, for historians, the interest of his account lies in his description of the Seventh Crusade.The aim of this Master thesis 1 is to consider, from the perspective of historical writing, Joinville’s contributions and to d

Protecting the borders is vital no matter the scale – be it a country, a private yard, or a living flesh. Every organism has its defense system and that is immunity. Yet, what immune mechanisms defend our borders from invaders simultaneously allowing for effective colonization by symbionts is a matter of debate. Mucocutaneous barrier is our physical border that is occupied by trillions of commens

Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of on